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- W2971378013 abstract "Abstract Members of the Apicomplexa phylum, including Plasmodium and Toxoplasma , have two types of secretory organelles (micronemes and rhoptries) whose sequential release is essential for invasion and the intracellular lifestyle of these eukaryotes. During invasion, rhoptries inject an array of invasion and virulence factors into the cytoplasm of the host cell, but the molecular mechanism mediating rhoptry exocytosis is unknown. Here we identify a set of parasite specific proteins, termed rhoptry apical surface proteins (RASP) that cap the extremity of the rhoptry. Depletion of RASP2 results in loss of rhoptry secretion and completely blocks parasite invasion and therefore parasite proliferation in both Toxoplasma and Plasmodium . Recombinant RASP2 binds charged lipids and likely contributes to assembling the machinery that docks/primes the rhoptry to the plasma membrane prior to fusion. This study provides important mechanistic insight into a parasite specific exocytic pathway, essential for the establishment of infection." @default.
- W2971378013 created "2019-09-12" @default.
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- W2971378013 date "2019-09-06" @default.
- W2971378013 modified "2023-10-18" @default.
- W2971378013 title "A lipid-binding protein mediates rhoptry discharge and invasion in Plasmodium falciparum and Toxoplasma gondii parasites" @default.
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- W2971378013 doi "https://doi.org/10.1038/s41467-019-11979-z" @default.
- W2971378013 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6731292" @default.
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- W2971378013 hasPublicationYear "2019" @default.
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