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• W2971379783 abstract "Mild traumatic brain injury (mTBI) disproportionately affects military service members and is very difficult to diagnose. To-date, there is currently no blood-based, diagnostic biomarker for mTBI cases with persistent post concussive symptoms. To examine the potential of neuronally-derived (NDE) and astrocytic-derived (ADE) exosome cargo proteins as biomarkers of chronic mTBI in younger adults, we examined plasma exosomes from a prospective longitudinal study of combat-related risk and resilience, marine resiliency study II (MRSII). After return from a combat-deployment participants were interviewed to assess TBI exposure while on deployment. Plasma exosomes from military service members with mTBI (mean age, 21.7 years, n = 19, avg. days since injury 151), and age-matched, controls (deployed service members who did not endorse a deployment-related TBI or a pre-deployment history of TBI; mean age, 21.95 years, n = 20) were precipitated and enriched against a neuronal adhesion protein, L1-CAM, and an astrocyte marker, glutamine aspartate transporter (GLAST) using magnetic beads to immunocapture the proteins and subsequently selected by fluorescent activated cell sorting (FACS). Extracted protein cargo from NDE and ADE preparations were quantified for protein levels implicated in TBI neuropathology by standard ELISAs and on the ultra-sensitive single molecule assay (Simoa) platform. Plasma NDE and ADE levels of Aβ42 were significantly higher while plasma NDE and ADE levels of the postsynaptic protein, neurogranin (NRGN) were significantly lower in participants endorsing mTBI exposure compared to controls with no TBI history. Plasma NDE and ADE levels of Aβ40, total tau, and neurofilament light (NFL), P-T181-tau, P-S396-tau were either undetectable or not significantly different between the two groups. In an effort to understand the pathogenetic potential of NDE and ADE cargo proteins, neuron-like cultures were treated with NDE and ADE preparations from TBI and non-TBI groups. Lastly, we determined that plasma NDE but not ADE cargo proteins from mTBI samples were found to be toxic to neuron-like recipient cells in vitro. These data support the presence of markers of neurodegeneration in NDEs of mTBI and suggest that these NDEs can be used as tools to identify pathogenic mechanisms of TBI." @default.
• W2971379783 created "2019-09-12" @default.
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• W2971379783 date "2019-10-02" @default.
• W2971379783 modified "2023-10-14" @default.
• W2971379783 title "Assessing Neuronal and Astrocyte Derived Exosomes From Individuals With Mild Traumatic Brain Injury for Markers of Neurodegeneration and Cytotoxic Activity" @default.
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• W2971379783 cites W1535804337 @default.
• W2971379783 cites W1789053989 @default.
• W2971379783 cites W1817922774 @default.
• W2971379783 cites W1970587959 @default.
• W2971379783 cites W1988603061 @default.
• W2971379783 cites W1990514899 @default.
• W2971379783 cites W1991893128 @default.
• W2971379783 cites W1995903088 @default.
• W2971379783 cites W2004631917 @default.
• W2971379783 cites W2006643577 @default.
• W2971379783 cites W2006645013 @default.
• W2971379783 cites W2009105636 @default.
• W2971379783 cites W2015284998 @default.
• W2971379783 cites W2020432242 @default.
• W2971379783 cites W2028459843 @default.
• W2971379783 cites W2044651402 @default.
• W2971379783 cites W2059035733 @default.
• W2971379783 cites W2061402690 @default.
• W2971379783 cites W2081325915 @default.
• W2971379783 cites W2090399754 @default.
• W2971379783 cites W2092154363 @default.
• W2971379783 cites W2093982682 @default.
• W2971379783 cites W2105070350 @default.
• W2971379783 cites W2127054028 @default.
• W2971379783 cites W2129636510 @default.
• W2971379783 cites W2130198578 @default.
• W2971379783 cites W2141679195 @default.
• W2971379783 cites W2152284042 @default.
• W2971379783 cites W2155656611 @default.
• W2971379783 cites W2156281143 @default.
• W2971379783 cites W2162660365 @default.
• W2971379783 cites W2170921124 @default.
• W2971379783 cites W2197374699 @default.
• W2971379783 cites W2280881439 @default.
• W2971379783 cites W2284769570 @default.
• W2971379783 cites W2352124481 @default.
• W2971379783 cites W2466729373 @default.
• W2971379783 cites W2479496252 @default.
• W2971379783 cites W2511373877 @default.
• W2971379783 cites W2537024319 @default.
• W2971379783 cites W2588761628 @default.
• W2971379783 cites W2606398663 @default.
• W2971379783 cites W2609504722 @default.
• W2971379783 cites W2612251171 @default.
• W2971379783 cites W2622572331 @default.
• W2971379783 cites W2624248893 @default.
• W2971379783 cites W2700330585 @default.
• W2971379783 cites W2738491178 @default.
• W2971379783 cites W2745416544 @default.
• W2971379783 cites W2750015292 @default.
• W2971379783 cites W2761598264 @default.
• W2971379783 cites W2762894517 @default.
• W2971379783 cites W2763743717 @default.
• W2971379783 cites W2769981087 @default.
• W2971379783 cites W2782753193 @default.
• W2971379783 cites W2790294879 @default.
• W2971379783 cites W2798127117 @default.
• W2971379783 cites W2798236352 @default.
• W2971379783 cites W2801321624 @default.
• W2971379783 cites W2802295301 @default.
• W2971379783 cites W2808596369 @default.
• W2971379783 cites W2808887222 @default.
• W2971379783 cites W2901388675 @default.
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• W2971379783 cites W2947364302 @default.
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• W2971379783 doi "https://doi.org/10.3389/fnins.2019.01005" @default.
• W2971379783 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6797846" @default.
• W2971379783 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31680797" @default.
• W2971379783 hasPublicationYear "2019" @default.
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