FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2971395209> ?p ?o ?g. }

• W2971395209 endingPage "1303" @default.
• W2971395209 startingPage "1303" @default.
• W2971395209 abstract "Marine sponge-derived manoalide has a potent anti-inflammatory effect, but its potential application as an anti-cancer drug has not yet been extensively investigated. The purpose of this study is to evaluate the antiproliferative effects of manoalide on oral cancer cells. MTS assay at 24 h showed that manoalide inhibited the proliferation of six types of oral cancer cell lines (SCC9, HSC3, OC2, OECM-1, Ca9-22, and CAL 27) but did not affect the proliferation of normal oral cell line (human gingival fibroblasts (HGF-1)). Manoalide also inhibits the ATP production from 3D sphere formation of Ca9-22 and CAL 27 cells. Mechanically, manoalide induces subG1 accumulation in oral cancer cells. Manoalide also induces more annexin V expression in oral cancer Ca9-22 and CAL 27 cells than that of HGF-1 cells. Manoalide induces activation of caspase 3 (Cas 3), which is a hallmark of apoptosis in oral cancer cells, Ca9-22 and CAL 27. Inhibitors of Cas 8 and Cas 9 suppress manoalide-induced Cas 3 activation. Manoalide induces higher reactive oxygen species (ROS) productions in Ca9-22 and CAL 27 cells than in HGF-1 cells. This oxidative stress induction by manoalide is further supported by mitochondrial superoxide (MitoSOX) production and mitochondrial membrane potential (MitoMP) destruction in oral cancer cells. Subsequently, manoalide-induced oxidative stress leads to DNA damages, such as γH2AX and 8-oxo-2’-deoxyguanosine (8-oxodG), in oral cancer cells. Effects, such as enhanced antiproliferation, apoptosis, oxidative stress, and DNA damage, in manoalide-treated oral cancer cells were suppressed by inhibitors of oxidative stress or apoptosis, or both, such as N-acetylcysteine (NAC) and Z-VAD-FMK (Z-VAD). Moreover, mitochondria-targeted superoxide inhibitor MitoTEMPO suppresses manoalide-induced MitoSOX generation and γH2AX/8-oxodG DNA damages. This study validates the preferential antiproliferation effect of manoalide and explores the oxidative stress-dependent mechanisms in anti-oral cancer treatment." @default.
• W2971395209 created "2019-09-12" @default.
• W2971395209 creator A5015537910 @default.
• W2971395209 creator A5039608131 @default.
• W2971395209 creator A5040790736 @default.
• W2971395209 creator A5059577264 @default.
• W2971395209 creator A5073515685 @default.
• W2971395209 creator A5074665298 @default.
• W2971395209 creator A5089081230 @default.
• W2971395209 date "2019-09-04" @default.
• W2971395209 modified "2023-10-15" @default.
• W2971395209 title "Manoalide Preferentially Provides Antiproliferation of Oral Cancer Cells by Oxidative Stress-Mediated Apoptosis and DNA Damage" @default.
• W2971395209 cites W1482693857 @default.
• W2971395209 cites W1576209843 @default.
• W2971395209 cites W1782856498 @default.
• W2971395209 cites W1909485236 @default.
• W2971395209 cites W1982426579 @default.
• W2971395209 cites W1986490038 @default.
• W2971395209 cites W1994733055 @default.
• W2971395209 cites W2006076303 @default.
• W2971395209 cites W2013993442 @default.
• W2971395209 cites W2018896176 @default.
• W2971395209 cites W2019051236 @default.
• W2971395209 cites W2022845707 @default.
• W2971395209 cites W2024936962 @default.
• W2971395209 cites W2033633290 @default.
• W2971395209 cites W2037586148 @default.
• W2971395209 cites W2041511542 @default.
• W2971395209 cites W2042041984 @default.
• W2971395209 cites W2046380842 @default.
• W2971395209 cites W2050072146 @default.
• W2971395209 cites W2050976987 @default.
• W2971395209 cites W2057312326 @default.
• W2971395209 cites W2058556541 @default.
• W2971395209 cites W2058701056 @default.
• W2971395209 cites W2064814263 @default.
• W2971395209 cites W2069073780 @default.
• W2971395209 cites W2070326852 @default.
• W2971395209 cites W2072257104 @default.
• W2971395209 cites W2075054107 @default.
• W2971395209 cites W2082969668 @default.
• W2971395209 cites W2085306302 @default.
• W2971395209 cites W2091012691 @default.
• W2971395209 cites W2095253802 @default.
• W2971395209 cites W2102851109 @default.
• W2971395209 cites W2103037071 @default.
• W2971395209 cites W2105688727 @default.
• W2971395209 cites W2106029128 @default.
• W2971395209 cites W2113313289 @default.
• W2971395209 cites W2116847204 @default.
• W2971395209 cites W2141232732 @default.
• W2971395209 cites W2148429762 @default.
• W2971395209 cites W2149428444 @default.
• W2971395209 cites W2154229994 @default.
• W2971395209 cites W2160980887 @default.
• W2971395209 cites W2162766713 @default.
• W2971395209 cites W2170008898 @default.
• W2971395209 cites W2267287632 @default.
• W2971395209 cites W2291113703 @default.
• W2971395209 cites W2339881780 @default.
• W2971395209 cites W2416776634 @default.
• W2971395209 cites W2548196609 @default.
• W2971395209 cites W2573794681 @default.
• W2971395209 cites W2588189174 @default.
• W2971395209 cites W2609245071 @default.
• W2971395209 cites W2624278037 @default.
• W2971395209 cites W2728625906 @default.
• W2971395209 cites W2752163938 @default.
• W2971395209 cites W2763435115 @default.
• W2971395209 cites W2768851472 @default.
• W2971395209 cites W2796283406 @default.
• W2971395209 cites W2806511422 @default.
• W2971395209 cites W2809911985 @default.
• W2971395209 cites W2810519118 @default.
• W2971395209 cites W2890463155 @default.
• W2971395209 cites W2899037384 @default.
• W2971395209 cites W4234505122 @default.
• W2971395209 cites W4250401874 @default.
• W2971395209 cites W4301499366 @default.
• W2971395209 cites W52810583 @default.
• W2971395209 doi "https://doi.org/10.3390/cancers11091303" @default.
• W2971395209 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6770486" @default.
• W2971395209 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31487907" @default.
• W2971395209 hasPublicationYear "2019" @default.
• W2971395209 type Work @default.
• W2971395209 sameAs 2971395209 @default.
• W2971395209 citedByCount "34" @default.
• W2971395209 countsByYear W29713952092020 @default.
• W2971395209 countsByYear W29713952092021 @default.
• W2971395209 countsByYear W29713952092022 @default.
• W2971395209 countsByYear W29713952092023 @default.
• W2971395209 crossrefType "journal-article" @default.
• W2971395209 hasAuthorship W2971395209A5015537910 @default.
• W2971395209 hasAuthorship W2971395209A5039608131 @default.
• W2971395209 hasAuthorship W2971395209A5040790736 @default.
• W2971395209 hasAuthorship W2971395209A5059577264 @default.
• W2971395209 hasAuthorship W2971395209A5073515685 @default.
• W2971395209 hasAuthorship W2971395209A5074665298 @default.

• next