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- W2971395772 abstract "Acidic extracellular pH (pHe) is an important microenvironment for cancer cells. This study assessed whether adaptation to acidic pHe enhances the metastatic phenotype of tumor cells. The low metastatic variant of Lewis lung carcinoma (LLCm1) cells were subjected to stepwise acidification, establishing acidic pHe-adapted (LLCm1A) cells growing exponentially at pH 6.2. These LLCm1A cells showed increased production of matrix metalloproteinases (MMPs), including MMP-2, -3, -9, and -13, and pulmonary metastasis following injection into mouse tail veins. Although LLCm1A cells exhibited a fibroblastic shape, keratin-5 expression was increased and α-smooth muscle actin expression was reduced. Despite serial passage of these cells at pH 7.4, high invasive activity through Matrigel® was sustained for at least 28 generations. Thus, adaptation to acidic pHe resulted in a more invasive phenotype, which was sustained during passage at pH 7.4, suggesting that an acidic microenvironment at the primary tumor site is important in the acquisition of a metastatic phenotype." @default.
- W2971395772 created "2019-09-12" @default.
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- W2971395772 date "2019-09-05" @default.
- W2971395772 modified "2023-10-17" @default.
- W2971395772 title "Adaptation to chronic acidic extracellular pH elicits a sustained increase in lung cancer cell invasion and metastasis" @default.
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- W2971395772 doi "https://doi.org/10.1007/s10585-019-09990-1" @default.
- W2971395772 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7007909" @default.
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