Matches in SemOpenAlex for { <https://semopenalex.org/work/W2971453650> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2971453650 endingPage "e1438" @default.
- W2971453650 startingPage "e1433" @default.
- W2971453650 abstract "To investigate substrate metabolism during exercise in an adult with lipin-1 deficiency, an inherited defect in lipid homeostasis, and to study the effect of glucose supplementation on his exercise tolerance.We studied a 48-year-old man with lipin-1 deficiency and 2 healthy men. The patient has exercise intolerance and monthly episodes of rhabdomyolysis. All participants performed a submaximal exercise test while total fatty acid oxidation (FAO) and palmitate oxidation rate were assessed by stable isotope technique and indirect calorimetry. On another day, the patient was infused with 10% glucose (410 mL/h) and repeated the exercise. On the third and fourth visits, he was randomized in a double-blind manner to drink a supplement of glucose (soft drink 2% concentration) or placebo (soft drink: aspartame, acesulfame-K) before and during exercise.Mean FAO and palmitate oxidation rate during exercise were lower in the patient vs controls: 431 vs 1,271 and 1912 μmol/min and 122 vs 191 and 212 μmol/min. Plasma fatty acid concentration was lower in the patient during exercise than in controls: 477 vs 643 and 630 μmol/L. The patient's exercise duration increased from 36 to 60 minutes with IV glucose and 46 minutes with oral glucose, and his rating of exertion dropped from 15 to 9 on average (Borg scale).In this adult lipin-1-deficient patient, FAO was reduced, which was associated with no increase in plasma free fatty acids during submaximal exercise, and his exercise capacity improved with continuous ingestion of high-dose glucose.NCT02635269." @default.
- W2971453650 created "2019-09-12" @default.
- W2971453650 creator A5004880821 @default.
- W2971453650 creator A5023248855 @default.
- W2971453650 creator A5048608555 @default.
- W2971453650 creator A5067846731 @default.
- W2971453650 creator A5078380336 @default.
- W2971453650 creator A5082182328 @default.
- W2971453650 date "2019-09-06" @default.
- W2971453650 modified "2023-09-27" @default.
- W2971453650 title "Fat oxidation is impaired during exercise in lipin-1 deficiency" @default.
- W2971453650 cites W1993137299 @default.
- W2971453650 cites W1998384937 @default.
- W2971453650 cites W2023089966 @default.
- W2971453650 cites W2037690696 @default.
- W2971453650 cites W2056384096 @default.
- W2971453650 cites W2075138393 @default.
- W2971453650 cites W2089441009 @default.
- W2971453650 cites W2132468746 @default.
- W2971453650 cites W2167842354 @default.
- W2971453650 cites W2782259363 @default.
- W2971453650 doi "https://doi.org/10.1212/wnl.0000000000008240" @default.
- W2971453650 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31492716" @default.
- W2971453650 hasPublicationYear "2019" @default.
- W2971453650 type Work @default.
- W2971453650 sameAs 2971453650 @default.
- W2971453650 citedByCount "6" @default.
- W2971453650 countsByYear W29714536502020 @default.
- W2971453650 countsByYear W29714536502021 @default.
- W2971453650 countsByYear W29714536502022 @default.
- W2971453650 crossrefType "journal-article" @default.
- W2971453650 hasAuthorship W2971453650A5004880821 @default.
- W2971453650 hasAuthorship W2971453650A5023248855 @default.
- W2971453650 hasAuthorship W2971453650A5048608555 @default.
- W2971453650 hasAuthorship W2971453650A5067846731 @default.
- W2971453650 hasAuthorship W2971453650A5078380336 @default.
- W2971453650 hasAuthorship W2971453650A5082182328 @default.
- W2971453650 hasConcept C126322002 @default.
- W2971453650 hasConcept C134018914 @default.
- W2971453650 hasConcept C142724271 @default.
- W2971453650 hasConcept C17093226 @default.
- W2971453650 hasConcept C185592680 @default.
- W2971453650 hasConcept C193230392 @default.
- W2971453650 hasConcept C204787440 @default.
- W2971453650 hasConcept C27081682 @default.
- W2971453650 hasConcept C2777953023 @default.
- W2971453650 hasConcept C2778004101 @default.
- W2971453650 hasConcept C2780928941 @default.
- W2971453650 hasConcept C2994476132 @default.
- W2971453650 hasConcept C543025807 @default.
- W2971453650 hasConcept C55493867 @default.
- W2971453650 hasConcept C62231903 @default.
- W2971453650 hasConcept C71924100 @default.
- W2971453650 hasConcept C82714985 @default.
- W2971453650 hasConcept C84393581 @default.
- W2971453650 hasConceptScore W2971453650C126322002 @default.
- W2971453650 hasConceptScore W2971453650C134018914 @default.
- W2971453650 hasConceptScore W2971453650C142724271 @default.
- W2971453650 hasConceptScore W2971453650C17093226 @default.
- W2971453650 hasConceptScore W2971453650C185592680 @default.
- W2971453650 hasConceptScore W2971453650C193230392 @default.
- W2971453650 hasConceptScore W2971453650C204787440 @default.
- W2971453650 hasConceptScore W2971453650C27081682 @default.
- W2971453650 hasConceptScore W2971453650C2777953023 @default.
- W2971453650 hasConceptScore W2971453650C2778004101 @default.
- W2971453650 hasConceptScore W2971453650C2780928941 @default.
- W2971453650 hasConceptScore W2971453650C2994476132 @default.
- W2971453650 hasConceptScore W2971453650C543025807 @default.
- W2971453650 hasConceptScore W2971453650C55493867 @default.
- W2971453650 hasConceptScore W2971453650C62231903 @default.
- W2971453650 hasConceptScore W2971453650C71924100 @default.
- W2971453650 hasConceptScore W2971453650C82714985 @default.
- W2971453650 hasConceptScore W2971453650C84393581 @default.
- W2971453650 hasIssue "15" @default.
- W2971453650 hasLocation W29714536501 @default.
- W2971453650 hasLocation W29714536502 @default.
- W2971453650 hasOpenAccess W2971453650 @default.
- W2971453650 hasPrimaryLocation W29714536501 @default.
- W2971453650 hasRelatedWork W1981456793 @default.
- W2971453650 hasRelatedWork W2003811568 @default.
- W2971453650 hasRelatedWork W2019374231 @default.
- W2971453650 hasRelatedWork W2041949500 @default.
- W2971453650 hasRelatedWork W2102326852 @default.
- W2971453650 hasRelatedWork W2102469932 @default.
- W2971453650 hasRelatedWork W2126771929 @default.
- W2971453650 hasRelatedWork W2154264779 @default.
- W2971453650 hasRelatedWork W2166313641 @default.
- W2971453650 hasRelatedWork W2748952813 @default.
- W2971453650 hasVolume "93" @default.
- W2971453650 isParatext "false" @default.
- W2971453650 isRetracted "false" @default.
- W2971453650 magId "2971453650" @default.
- W2971453650 workType "article" @default.