FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2971461481> ?p ?o ?g. }

• W2971461481 endingPage "134297" @default.
• W2971461481 startingPage "134297" @default.
• W2971461481 abstract "Although endocrine disrupting compounds have been detected in wastewater and surface waters worldwide using a variety of in vitro effects-based screening tools, e.g. bioassays, few have examined potential attenuation of environmental contaminants by both natural (sorption, degradation, etc.) and anthropogenic (water treatment practices) processes. This study used several bioassays and quantitative chemical analyses to assess residence-time weighted samples at six sites along a river in the northeastern United States beginning upstream from a wastewater treatment plant outfall and proceeding downstream along the stream reach to a drinking water treatment plant. Known steroidal estrogens were quantified and changes in signaling pathway molecular initiating events (activation of estrogen, androgen, glucocorticoid, peroxisome proliferator-activated, pregnane X receptor, and aryl hydrocarbon receptor signaling networks) were identified in water extracts. In initial multi-endpoint assays geographic and receptor-specific endocrine activity patterns in transcription factor signatures and nuclear receptor activation were discovered. In subsequent single endpoint receptor-specific bioassays, estrogen (16 of 18 samples; 0.01 to 28 ng estradiol equivalents [E2Eqs]/L) glucocorticoid (3 of 18 samples; 1.8 to 21 ng dexamethasone equivalents [DexEqs]/L), and androgen (2 of 18 samples; 0.95 to 2.1 ng dihydrotestosterone equivalents [DHTEqs]/L) receptor transcriptional activation occurred above respective assay method detection limits (0.04 ng E2Eqs/L, 1.2 ng DexEqs/L, and 0.77 ng DHTEqs/L) in multiple sampling events. Estrogen activity, the most often detected, correlated well with measured concentrations of known steroidal estrogens (r2 = 0.890). Overall, activity indicative of multiple types of endocrine active compounds was highest in wastewater effluent samples, while activity downstream was progressively lower, and negligible in unfinished treated drinking water. Not only was estrogenic and glucocorticoid activity confirmed in the effluent by utilizing multiple methods concurrently, but other activated signaling networks that historically received less attention (i.e. peroxisome proliferator-activated receptor) were also detected." @default.
• W2971461481 created "2019-09-12" @default.
• W2971461481 creator A5001390078 @default.
• W2971461481 creator A5003573402 @default.
• W2971461481 creator A5005402297 @default.
• W2971461481 creator A5022593051 @default.
• W2971461481 creator A5026042194 @default.
• W2971461481 creator A5036020393 @default.
• W2971461481 creator A5044171138 @default.
• W2971461481 creator A5047085960 @default.
• W2971461481 creator A5053170273 @default.
• W2971461481 creator A5054264185 @default.
• W2971461481 creator A5059785684 @default.
• W2971461481 creator A5062975223 @default.
• W2971461481 creator A5071490929 @default.
• W2971461481 creator A5082012164 @default.
• W2971461481 creator A5087097583 @default.
• W2971461481 date "2020-01-01" @default.
• W2971461481 modified "2023-10-15" @default.
• W2971461481 title "De Facto Water Reuse: Bioassay suite approach delivers depth and breadth in endocrine active compound detection" @default.
• W2971461481 cites W1958831354 @default.
• W2971461481 cites W1964644005 @default.
• W2971461481 cites W1974172315 @default.
• W2971461481 cites W1974926081 @default.
• W2971461481 cites W1982297880 @default.
• W2971461481 cites W1984208790 @default.
• W2971461481 cites W1990814794 @default.
• W2971461481 cites W1991185023 @default.
• W2971461481 cites W1999156812 @default.
• W2971461481 cites W2000089305 @default.
• W2971461481 cites W2005135645 @default.
• W2971461481 cites W2014622549 @default.
• W2971461481 cites W2016572372 @default.
• W2971461481 cites W2017938557 @default.
• W2971461481 cites W2018618837 @default.
• W2971461481 cites W2021591445 @default.
• W2971461481 cites W2023887872 @default.
• W2971461481 cites W2024033014 @default.
• W2971461481 cites W2036963048 @default.
• W2971461481 cites W2037766564 @default.
• W2971461481 cites W2039023381 @default.
• W2971461481 cites W2050698392 @default.
• W2971461481 cites W2056266765 @default.
• W2971461481 cites W2068768059 @default.
• W2971461481 cites W2083484766 @default.
• W2971461481 cites W2096401943 @default.
• W2971461481 cites W2108873714 @default.
• W2971461481 cites W2117359176 @default.
• W2971461481 cites W2119745101 @default.
• W2971461481 cites W2120798598 @default.
• W2971461481 cites W2131274688 @default.
• W2971461481 cites W2131984758 @default.
• W2971461481 cites W2133100606 @default.
• W2971461481 cites W2135415633 @default.
• W2971461481 cites W2157723767 @default.
• W2971461481 cites W2167782130 @default.
• W2971461481 cites W2169412126 @default.
• W2971461481 cites W2274036806 @default.
• W2971461481 cites W2285823523 @default.
• W2971461481 cites W2327251869 @default.
• W2971461481 cites W2344578960 @default.
• W2971461481 cites W2502978712 @default.
• W2971461481 cites W2508410539 @default.
• W2971461481 cites W2555539164 @default.
• W2971461481 cites W2566457578 @default.
• W2971461481 cites W2606787356 @default.
• W2971461481 cites W2606882354 @default.
• W2971461481 cites W2611388101 @default.
• W2971461481 cites W2624992950 @default.
• W2971461481 cites W2788898240 @default.
• W2971461481 cites W2789698926 @default.
• W2971461481 cites W2794967074 @default.
• W2971461481 cites W2795215758 @default.
• W2971461481 cites W2810710529 @default.
• W2971461481 cites W2885046920 @default.
• W2971461481 cites W2885712848 @default.
• W2971461481 cites W2904193877 @default.
• W2971461481 cites W2919023285 @default.
• W2971461481 cites W297083069 @default.
• W2971461481 cites W302202833 @default.
• W2971461481 doi "https://doi.org/10.1016/j.scitotenv.2019.134297" @default.
• W2971461481 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31683213" @default.
• W2971461481 hasPublicationYear "2020" @default.
• W2971461481 type Work @default.
• W2971461481 sameAs 2971461481 @default.
• W2971461481 citedByCount "20" @default.
• W2971461481 countsByYear W29714614812020 @default.
• W2971461481 countsByYear W29714614812021 @default.
• W2971461481 countsByYear W29714614812022 @default.
• W2971461481 countsByYear W29714614812023 @default.
• W2971461481 crossrefType "journal-article" @default.
• W2971461481 hasAuthorship W2971461481A5001390078 @default.
• W2971461481 hasAuthorship W2971461481A5003573402 @default.
• W2971461481 hasAuthorship W2971461481A5005402297 @default.
• W2971461481 hasAuthorship W2971461481A5022593051 @default.
• W2971461481 hasAuthorship W2971461481A5026042194 @default.
• W2971461481 hasAuthorship W2971461481A5036020393 @default.
• W2971461481 hasAuthorship W2971461481A5044171138 @default.

• next