FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2971508997> ?p ?o ?g. }

• W2971508997 endingPage "375" @default.
• W2971508997 startingPage "362" @default.
• W2971508997 abstract "Abstract Extracellular vesicles (EVs) are nanoparticles secreted by ovarian follicle cells. Extracellular vesicles are an important form of intercellular communication, since they carry bioactive contents, such as microRNAs (miRNAs), mRNAs, and proteins. MicroRNAs are small noncoding RNA capable of modulating mRNA translation. Thus, EVs can play a role in follicle and oocyte development. However, it is not clear if EV contents vary with the estrous cycle stage. The aim of this study was to investigate the bovine miRNA content in EVs obtained from follicles at different estrous cycle stages, which are associated with different progesterone (P4) levels in the follicular fluid (FF). We collected FF from 3 to 6 mm follicles and evaluated the miRNA profile of the EVs and their effects on cumulus-oocyte complexes during in vitro maturation. We observed that EVs from low P4 group have a higher abundance of miRNAs predicted to modulate pathways, such as MAPK, RNA transport, Hippo, Cell cycle, FoxO, oocyte meiosis, and TGF-beta. Additionally, EVs were taken up by cumulus cells and, thus, affected the RNA global profile 9 h after EV supplementation. Cumulus cells supplemented with EVs from low P4 presented upregulated genes that could modulate biological processes, such as oocyte development, immune responses, and Notch signaling compared with genes of cumulus cells in the EV free media or with EVs from high P4 follicles. In conclusion, our results demonstrate that EV miRNA contents are distinct in follicles exposed to different estrous cycle stage. Supplementation with EVs impacts gene expression and biological processes in cumulus cells." @default.
• W2971508997 created "2019-09-12" @default.
• W2971508997 creator A5015303463 @default.
• W2971508997 creator A5020797054 @default.
• W2971508997 creator A5021587514 @default.
• W2971508997 creator A5029367598 @default.
• W2971508997 creator A5051379700 @default.
• W2971508997 creator A5053993029 @default.
• W2971508997 creator A5067823034 @default.
• W2971508997 creator A5069072180 @default.
• W2971508997 creator A5069591363 @default.
• W2971508997 creator A5072335040 @default.
• W2971508997 creator A5089359793 @default.
• W2971508997 creator A5091323560 @default.
• W2971508997 date "2019-09-02" @default.
• W2971508997 modified "2023-10-13" @default.
• W2971508997 title "Estrous cycle impacts microRNA content in extracellular vesicles that modulate bovine cumulus cell transcripts during in vitro maturation†" @default.
• W2971508997 cites W1664580441 @default.
• W2971508997 cites W1933062837 @default.
• W2971508997 cites W1967490869 @default.
• W2971508997 cites W1975224679 @default.
• W2971508997 cites W1983741029 @default.
• W2971508997 cites W1986321004 @default.
• W2971508997 cites W1991741273 @default.
• W2971508997 cites W1996354329 @default.
• W2971508997 cites W2001129558 @default.
• W2971508997 cites W2005993715 @default.
• W2971508997 cites W2033206940 @default.
• W2971508997 cites W2035254745 @default.
• W2971508997 cites W2035618305 @default.
• W2971508997 cites W2035975216 @default.
• W2971508997 cites W2037919601 @default.
• W2971508997 cites W2042114928 @default.
• W2971508997 cites W2046758915 @default.
• W2971508997 cites W2054410308 @default.
• W2971508997 cites W2055313665 @default.
• W2971508997 cites W2058565087 @default.
• W2971508997 cites W2061009724 @default.
• W2971508997 cites W2064292256 @default.
• W2971508997 cites W2066432115 @default.
• W2971508997 cites W2083205981 @default.
• W2971508997 cites W2086589603 @default.
• W2971508997 cites W2096035039 @default.
• W2971508997 cites W2101748305 @default.
• W2971508997 cites W2105626017 @default.
• W2971508997 cites W2108448395 @default.
• W2971508997 cites W2108500887 @default.
• W2971508997 cites W2110778029 @default.
• W2971508997 cites W2117444223 @default.
• W2971508997 cites W2121334967 @default.
• W2971508997 cites W2122667024 @default.
• W2971508997 cites W2125920557 @default.
• W2971508997 cites W2129072528 @default.
• W2971508997 cites W2131271579 @default.
• W2971508997 cites W2133586829 @default.
• W2971508997 cites W2138116691 @default.
• W2971508997 cites W2138664009 @default.
• W2971508997 cites W2140449918 @default.
• W2971508997 cites W2141486024 @default.
• W2971508997 cites W2146642335 @default.
• W2971508997 cites W2158010257 @default.
• W2971508997 cites W2159274708 @default.
• W2971508997 cites W2159401023 @default.
• W2971508997 cites W2163695525 @default.
• W2971508997 cites W2166866919 @default.
• W2971508997 cites W2168858740 @default.
• W2971508997 cites W2169456326 @default.
• W2971508997 cites W2178257606 @default.
• W2971508997 cites W2179438025 @default.
• W2971508997 cites W2180001106 @default.
• W2971508997 cites W2265355159 @default.
• W2971508997 cites W2346473963 @default.
• W2971508997 cites W2412308920 @default.
• W2971508997 cites W2432815617 @default.
• W2971508997 cites W2591717348 @default.
• W2971508997 cites W2591948507 @default.
• W2971508997 cites W2618161529 @default.
• W2971508997 cites W2625194438 @default.
• W2971508997 cites W2727818991 @default.
• W2971508997 cites W2749918987 @default.
• W2971508997 cites W2762669405 @default.
• W2971508997 cites W2765825960 @default.
• W2971508997 cites W2767736783 @default.
• W2971508997 cites W2784286913 @default.
• W2971508997 cites W2789518613 @default.
• W2971508997 cites W2888315476 @default.
• W2971508997 cites W30488176 @default.
• W2971508997 cites W37849047 @default.
• W2971508997 doi "https://doi.org/10.1093/biolre/ioz177" @default.
• W2971508997 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31504242" @default.
• W2971508997 hasPublicationYear "2019" @default.
• W2971508997 type Work @default.
• W2971508997 sameAs 2971508997 @default.
• W2971508997 citedByCount "30" @default.
• W2971508997 countsByYear W29715089972020 @default.
• W2971508997 countsByYear W29715089972021 @default.
• W2971508997 countsByYear W29715089972022 @default.
• W2971508997 countsByYear W29715089972023 @default.

• next