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- W297151520 abstract "Nuclear Magnetic Resonance (NMR) spectroscopy is an information-rich method, and many of the spectral parameters can be interpreted directly in terms of conformation or dynamics. As with any kind of spectroscopy, each peak (or resonance) represents a transition between a ground and an excited state. The frequency of the resonance (the chemical shift) is in principle different for each magnetically active nucleus in the molecule. This arises mainly from a combination of the details of chemical bonding and electronegativity of atoms, and to the local magnetic fields generated by the electrons in the bonding network. It is this sensitivity to chemical environment that makes NMR such a powerful form of spectroscopy. The basic procedure for NMR analysis of drug–DNA interactions is the same regardless of the particular system, and involves assignment of the signals of the DNA and drug, both free and in the complex. Increasing magnetic field strength affords greater spectral dispersion and sensitivity, allowing the study of more complex systems, or current systems at much higher dilution (as well as with improved resolution). An additional benefit of ultrahigh field strength is magnetic ordering. Because nucleic acids contain linear stacks of aromatic rings, which are themselves strongly magnetically anisotropic, long polymers have a high degree of anisotropy in the magnetic susceptibility, and therefore orient in a magnetic field." @default.
- W297151520 created "2016-06-24" @default.
- W297151520 creator A5029157205 @default.
- W297151520 date "2001-01-01" @default.
- W297151520 modified "2023-10-11" @default.
- W297151520 title "Nuclear magnetic resonance studies of drug-DNA complexes in solution" @default.
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- W297151520 doi "https://doi.org/10.1016/s0076-6879(01)40426-5" @default.
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