FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2971537112> ?p ?o ?g. }

• W2971537112 abstract "The advent of novel, innovative, and effective anti-cancer immunotherapies has engendered an era of renewed optimism among cancer specialists and their patients. Foremost among these successful immunotherapies are monoclonal antibodies (MAbs) which target immune checkpoint inhibitor (ICI) molecules, most prominently cytotoxic T-lymphocyte-associated protein (CTLA-4) and programmed cell death protein-1 (PD-1) and its major ligand, PD-L1. These immunotherapeutic agents are, however, often associated with the occurrence of immune-mediated toxicities known as immune-related adverse events (IRAEs). The incidence of severe toxicities increases substantially when these agents are used together, particularly with CTLA-4 in combination with PD-1 or PD-L1 antagonists. Accordingly, dissociating the beneficial anti-tumor therapeutic activity of these agents from the emergence of IRAEs represents a significant challenge to attaining the optimum efficacy of ICI-targeted immunotherapy of cancer. This situation is compounded by an increasing awareness, possibly unsurprising, that both the beneficial and harmful effects of ICI-targeted therapies appear to result from an over-reactive immune system. Nevertheless, this challenge may not be insurmountable. This contention is based on acquisition of recent insights into the role of the gut microbiome and its products as determinants of the efficacy of ICI-targeted immunotherapy, as well as an increasing realization of the enigmatic involvement of Th17 cells in both anti-tumor activity and the pathogenesis of some types of IRAEs. Evidence linking the beneficial and harmful activities of ICI-targeted immunotherapy, recent mechanistic insights focusing on the gut microbiome and Th17 cells, as well as strategies to attenuate IRAEs in the setting of retention of therapeutic activity, therefore represent the major thrusts of this review." @default.
• W2971537112 created "2019-09-12" @default.
• W2971537112 creator A5021461215 @default.
• W2971537112 creator A5036251909 @default.
• W2971537112 creator A5043177871 @default.
• W2971537112 date "2019-09-26" @default.
• W2971537112 modified "2023-10-10" @default.
• W2971537112 title "Immunopathogenesis of Immune Checkpoint Inhibitor-Related Adverse Events: Roles of the Intestinal Microbiome and Th17 Cells" @default.
• W2971537112 cites W1538902372 @default.
• W2971537112 cites W1705652018 @default.
• W2971537112 cites W1985361047 @default.
• W2971537112 cites W2004774344 @default.
• W2971537112 cites W2008539591 @default.
• W2971537112 cites W2008692337 @default.
• W2971537112 cites W2014557161 @default.
• W2971537112 cites W2018223096 @default.
• W2971537112 cites W2048502267 @default.
• W2971537112 cites W2049646220 @default.
• W2971537112 cites W2051529467 @default.
• W2971537112 cites W2053763669 @default.
• W2971537112 cites W2058487327 @default.
• W2971537112 cites W2068119757 @default.
• W2971537112 cites W2075691631 @default.
• W2971537112 cites W2087482409 @default.
• W2971537112 cites W2094366129 @default.
• W2971537112 cites W2104732141 @default.
• W2971537112 cites W2106190040 @default.
• W2971537112 cites W2108933323 @default.
• W2971537112 cites W2109653150 @default.
• W2971537112 cites W2120499377 @default.
• W2971537112 cites W2124332626 @default.
• W2971537112 cites W2125082756 @default.
• W2971537112 cites W2137712039 @default.
• W2971537112 cites W2140374399 @default.
• W2971537112 cites W2145706989 @default.
• W2971537112 cites W2153942285 @default.
• W2971537112 cites W2166226087 @default.
• W2971537112 cites W2173856514 @default.
• W2971537112 cites W2180349132 @default.
• W2971537112 cites W2185409974 @default.
• W2971537112 cites W2263759961 @default.
• W2971537112 cites W2272340815 @default.
• W2971537112 cites W2299004983 @default.
• W2971537112 cites W2323655202 @default.
• W2971537112 cites W2342000077 @default.
• W2971537112 cites W2344489622 @default.
• W2971537112 cites W2345440079 @default.
• W2971537112 cites W2365243214 @default.
• W2971537112 cites W2441690768 @default.
• W2971537112 cites W2464216504 @default.
• W2971537112 cites W2471699783 @default.
• W2971537112 cites W2509332865 @default.
• W2971537112 cites W2513710094 @default.
• W2971537112 cites W2525217971 @default.
• W2971537112 cites W2552260644 @default.
• W2971537112 cites W2554931714 @default.
• W2971537112 cites W2561370981 @default.
• W2971537112 cites W2563267837 @default.
• W2971537112 cites W2566809924 @default.
• W2971537112 cites W2571686442 @default.
• W2971537112 cites W2581399452 @default.
• W2971537112 cites W2589016133 @default.
• W2971537112 cites W2589413895 @default.
• W2971537112 cites W2601055810 @default.
• W2971537112 cites W2606710145 @default.
• W2971537112 cites W2610329572 @default.
• W2971537112 cites W2610919492 @default.
• W2971537112 cites W2615312978 @default.
• W2971537112 cites W2619425167 @default.
• W2971537112 cites W2635292439 @default.
• W2971537112 cites W266144465 @default.
• W2971537112 cites W2719999682 @default.
• W2971537112 cites W2734522096 @default.
• W2971537112 cites W2734586792 @default.
• W2971537112 cites W2750254726 @default.
• W2971537112 cites W2754877046 @default.
• W2971537112 cites W2756666776 @default.
• W2971537112 cites W2760874344 @default.
• W2971537112 cites W2761905894 @default.
• W2971537112 cites W2763732021 @default.
• W2971537112 cites W2765314233 @default.
• W2971537112 cites W2766111392 @default.
• W2971537112 cites W2766903152 @default.
• W2971537112 cites W2767343890 @default.
• W2971537112 cites W2768499948 @default.
• W2971537112 cites W2770404972 @default.
• W2971537112 cites W2776592021 @default.
• W2971537112 cites W2778362492 @default.
• W2971537112 cites W2782333299 @default.
• W2971537112 cites W2783137027 @default.
• W2971537112 cites W2785613599 @default.
• W2971537112 cites W2788965853 @default.
• W2971537112 cites W2789417379 @default.
• W2971537112 cites W2792492929 @default.
• W2971537112 cites W2793633504 @default.
• W2971537112 cites W2795186863 @default.
• W2971537112 cites W2795354240 @default.
• W2971537112 cites W2796582438 @default.
• W2971537112 cites W2797068438 @default.
• W2971537112 cites W2800382185 @default.

• next