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• W2971552470 abstract "Attempts to identify opioid users at increased risk of escalating to opioid use disorder have had limited success. Data from a variety of sources suggest that genetic variation may mediate the subjective response to opioid drugs, and therefore contribute to their abuse potential. The goal of the current study was to observe the relationship between select genetic polymorphisms and the subjective effects of oxycodone under controlled clinical laboratory conditions. Non-dependent, volunteers with some history of prescription opioid exposure (N = 36) provided a blood sample for analyses of variations in the genes that encode for the μ-, κ- and δ-opioid receptors, and the dopamine metabolizing enzyme, catechol-O-methyltransferase (COMT). Participants then completed a single laboratory test session to evaluate the subjective and analgesic effects of oral oxycodone (0, 10, and 20 mg, cumulative dose = 30 mg). Oxycodone produced typical μ-opioid receptor agonist effects, such as miosis, and decreased pain perception. Oxycodone also produced dose-dependent increases in positive subjective responses such as: drug “Liking” and “Good Effect.” Genetic variants in the μ- (rs6848893) and δ-opioid receptor (rs581111) influenced the responses to oxycodone administration. Additionally, self-reported “Stimulated” effects of oxycodone varied significantly as a function of COMT rs4680 genotype. The current study shows that the euphoric and stimulating effects of oxycodone can vary as a function of genetic variation. Though the relationship between the stimulating effects of opioids and their abuse liability is not well established, we know that the ability of opioids to provide intense feelings of pleasure is a significant motivator for continued use. If replicated, specific genetic variants may be useful in predicting who is at increased risk of developing maladaptive patterns of use following medical exposure to opioid analgesics." @default.
• W2971552470 created "2019-09-12" @default.
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• W2971552470 date "2019-11-01" @default.
• W2971552470 modified "2023-09-23" @default.
• W2971552470 title "Assessing the contribution of opioid- and dopamine-related genetic polymorphisms to the abuse liability of oxycodone" @default.
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• W2971552470 doi "https://doi.org/10.1016/j.pbb.2019.172778" @default.
• W2971552470 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6801039" @default.
• W2971552470 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31493434" @default.
• W2971552470 hasPublicationYear "2019" @default.
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