Matches in SemOpenAlex for { <https://semopenalex.org/work/W2971567752> ?p ?o ?g. }
- W2971567752 endingPage "363" @default.
- W2971567752 startingPage "345" @default.
- W2971567752 abstract "Neuronal loss is the best neuropathological substrate that correlates with cortical atrophy and dementia in Alzheimer's disease (AD). Defective GABAergic neuronal functions may lead to cortical network hyperactivity and aberrant neuronal oscillations and in consequence, generate a detrimental alteration in memory processes. In this study, using immunohistochemical and stereological approaches, we report that the two major and non-overlapping groups of inhibitory interneurons (SOM-cells and PV-cells) displayed distinct vulnerability in the perirhinal cortex of APP/PS1 mice and AD patients. SOM-positive neurons were notably sensitive and exhibited a dramatic decrease in the perirhinal cortex of 6-month-old transgenic mice (57% and 61% in areas 36 and 35, respectively) and, most importantly, in AD patients (91% in Braak V-VI cases). In addition, this interneuron degenerative process seems to occur in parallel, and closely related, with the progression of the amyloid pathology. However, the population expressing PV was unaffected in APP/PS1 mice while in AD brains suffered a pronounced and significant loss (69%). As a key component of cortico-hippocampal networks, the perirhinal cortex plays an important role in memory processes, especially in familiarity-based memory recognition. Therefore, disrupted functional connectivity of this cortical region, as a result of the early SOM and PV neurodegeneration, might contribute to the altered brain rhythms and cognitive failures observed in the initial clinical phase of AD patients. Finally, these findings highlight the failure of amyloidogenic AD models to fully recapitulate the selective neuronal degeneration occurring in humans." @default.
- W2971567752 created "2019-09-12" @default.
- W2971567752 creator A5001982801 @default.
- W2971567752 creator A5006306026 @default.
- W2971567752 creator A5006946812 @default.
- W2971567752 creator A5014963985 @default.
- W2971567752 creator A5017246570 @default.
- W2971567752 creator A5018650152 @default.
- W2971567752 creator A5019557946 @default.
- W2971567752 creator A5035625971 @default.
- W2971567752 creator A5059300233 @default.
- W2971567752 creator A5064941788 @default.
- W2971567752 creator A5068634411 @default.
- W2971567752 creator A5084561391 @default.
- W2971567752 creator A5088000138 @default.
- W2971567752 date "2019-10-09" @default.
- W2971567752 modified "2023-10-18" @default.
- W2971567752 title "Distinct disease‐sensitive GABAergic neurons in the perirhinal cortex of Alzheimer's mice and patients" @default.
- W2971567752 cites W1510052211 @default.
- W2971567752 cites W1521981527 @default.
- W2971567752 cites W1530682407 @default.
- W2971567752 cites W1545362509 @default.
- W2971567752 cites W1551466091 @default.
- W2971567752 cites W1906116459 @default.
- W2971567752 cites W1968453815 @default.
- W2971567752 cites W1969409776 @default.
- W2971567752 cites W1970719523 @default.
- W2971567752 cites W1971222486 @default.
- W2971567752 cites W1976280690 @default.
- W2971567752 cites W1979612107 @default.
- W2971567752 cites W1981590453 @default.
- W2971567752 cites W1982064952 @default.
- W2971567752 cites W1984052890 @default.
- W2971567752 cites W1984851727 @default.
- W2971567752 cites W1992836831 @default.
- W2971567752 cites W1996730507 @default.
- W2971567752 cites W2001334299 @default.
- W2971567752 cites W2001428953 @default.
- W2971567752 cites W2004852048 @default.
- W2971567752 cites W2008538896 @default.
- W2971567752 cites W2017706994 @default.
- W2971567752 cites W2018559652 @default.
- W2971567752 cites W2024438481 @default.
- W2971567752 cites W2027779538 @default.
- W2971567752 cites W2034969383 @default.
- W2971567752 cites W2035466313 @default.
- W2971567752 cites W2042315877 @default.
- W2971567752 cites W2048029392 @default.
- W2971567752 cites W2052742260 @default.
- W2971567752 cites W2053790717 @default.
- W2971567752 cites W2055156009 @default.
- W2971567752 cites W2056994923 @default.
- W2971567752 cites W2058110291 @default.
- W2971567752 cites W2060687819 @default.
- W2971567752 cites W2067616890 @default.
- W2971567752 cites W2068010400 @default.
- W2971567752 cites W2069771865 @default.
- W2971567752 cites W2079490962 @default.
- W2971567752 cites W2080516466 @default.
- W2971567752 cites W2080781505 @default.
- W2971567752 cites W2081016744 @default.
- W2971567752 cites W2081908529 @default.
- W2971567752 cites W2082796074 @default.
- W2971567752 cites W2090429689 @default.
- W2971567752 cites W2093613378 @default.
- W2971567752 cites W2093650784 @default.
- W2971567752 cites W2093898957 @default.
- W2971567752 cites W2113861132 @default.
- W2971567752 cites W2117367777 @default.
- W2971567752 cites W2130415071 @default.
- W2971567752 cites W2132227554 @default.
- W2971567752 cites W2132816327 @default.
- W2971567752 cites W2144749167 @default.
- W2971567752 cites W2145748909 @default.
- W2971567752 cites W2149423990 @default.
- W2971567752 cites W2162462376 @default.
- W2971567752 cites W2163951898 @default.
- W2971567752 cites W2314890784 @default.
- W2971567752 cites W2386517867 @default.
- W2971567752 cites W2464201598 @default.
- W2971567752 cites W2474663031 @default.
- W2971567752 cites W2503929286 @default.
- W2971567752 cites W2519528771 @default.
- W2971567752 cites W2526401721 @default.
- W2971567752 cites W2531096663 @default.
- W2971567752 cites W2531263448 @default.
- W2971567752 cites W2531941507 @default.
- W2971567752 cites W2549366107 @default.
- W2971567752 cites W2560234750 @default.
- W2971567752 cites W2606834381 @default.
- W2971567752 cites W2612505059 @default.
- W2971567752 cites W2743313139 @default.
- W2971567752 cites W2766591128 @default.
- W2971567752 cites W2773321573 @default.
- W2971567752 cites W2791311505 @default.
- W2971567752 cites W2804646831 @default.
- W2971567752 cites W2893027574 @default.
- W2971567752 cites W2894521163 @default.