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- W2971612155 abstract "Non-melanoma skin cancers (NMSC) arise from keratinocytes, the main epidermal cell type, and are considered one of the most frequent malignancies worldwide. Among them, cutaneous squamous cell carcinoma (cSCC) represents the clinically most important tumor type due to its substantial risk of metastasis. Chronic exposure to ultraviolet radiation (UVR) is the main cause of cSCC, which typically arises in highly exposed regions like the head or the neck from precursor and in situ lesions, such as actinic keratosis (AK) or Bowen’s disease, respectively. We have recently shown that AK and cSCC methylomes are highly similar, suggesting a significant malignant potential for the precancerous lesion. This study, based on Infinium MethylationEPIC BeadChips, also revealed that DNA methylation can be used to unambiguously subclassify AK and cSCC according to the epigenetic programs of two distinct cells-of-origin, two keratinocytes in distinct differentiation stages. Building on this basis, we have now expanded our epigenomic analysis to other epidermal malignancies such as Bowen’s disease or the most common NMSC, basal cell carcinoma (BCC). Moreover, we have also included in the study a benign epidermal tumor, verruca seborrhoica. Among other findings, our data based on about 100 samples demonstrate that all epidermal entities can be stratified into the two previously observed methylation-based subclasses, and also suggest a prognostic potential for cSCC stratification. Enhancer methylation profiling of the samples prompts the use of single-cell technologies to identify and further characterize the cells-of-origin of the different epidermal entities." @default.
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- W2971612155 date "2019-09-01" @default.
- W2971612155 modified "2023-09-27" @default.
- W2971612155 title "469 Epigenomic characterization of non-melanoma skin cancer" @default.
- W2971612155 doi "https://doi.org/10.1016/j.jid.2019.07.519" @default.
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