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- W2971640557 abstract "Inflammatory arthritis including rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA) exhibit the shared feature of changes in activation and polarization of circulating monocytes and tissue macrophages. Numerous microRNAs (miRs) have been found to have key functions in regulating inflammation and macrophage polarization. Although there is increasing interest in the roles of miRs in both RA and JIA, less is known regarding how miRs relate to functional properties of immune cells, including monocytes and macrophages. Interestingly, miRs can function both to promote inflammatory phenotypes and pro-inflammatory polarization, as well as through negative-feedback loops to limit inflammation. Here, we review the functional roles of several miRs in macrophages in inflammatory arthritis, with a particular focus on vivo effects of miR alteration in experimental arthritis. We also consider how current efforts to target miRs clinically could modify functional monocyte and macrophage polarization in vivo, and serve as novel therapies for diseases such as RA and JIA." @default.
- W2971640557 created "2019-09-12" @default.
- W2971640557 creator A5002868596 @default.
- W2971640557 creator A5063314351 @default.
- W2971640557 date "2019-09-13" @default.
- W2971640557 modified "2023-10-16" @default.
- W2971640557 title "Functional Regulation of Macrophage Phenotypes by MicroRNAs in Inflammatory Arthritis" @default.
- W2971640557 cites W107023457 @default.
- W2971640557 cites W115734860 @default.
- W2971640557 cites W1248878113 @default.
- W2971640557 cites W1639959100 @default.
- W2971640557 cites W1892182006 @default.
- W2971640557 cites W1915908724 @default.
- W2971640557 cites W1969430735 @default.
- W2971640557 cites W1973847028 @default.
- W2971640557 cites W1979206745 @default.
- W2971640557 cites W1989029018 @default.
- W2971640557 cites W1996441871 @default.
- W2971640557 cites W1996639668 @default.
- W2971640557 cites W1999177075 @default.
- W2971640557 cites W2000931416 @default.
- W2971640557 cites W2007239127 @default.
- W2971640557 cites W2007276591 @default.
- W2971640557 cites W2019583561 @default.
- W2971640557 cites W2033209163 @default.
- W2971640557 cites W2033459613 @default.
- W2971640557 cites W2041885763 @default.
- W2971640557 cites W2045397037 @default.
- W2971640557 cites W2050359926 @default.
- W2971640557 cites W2059695215 @default.
- W2971640557 cites W2065210647 @default.
- W2971640557 cites W2070163115 @default.
- W2971640557 cites W2070985562 @default.
- W2971640557 cites W2075728036 @default.
- W2971640557 cites W2096115110 @default.
- W2971640557 cites W2101866294 @default.
- W2971640557 cites W2102500432 @default.
- W2971640557 cites W2102901373 @default.
- W2971640557 cites W2119282152 @default.
- W2971640557 cites W2119949093 @default.
- W2971640557 cites W2123366371 @default.
- W2971640557 cites W2125792512 @default.
- W2971640557 cites W2133613657 @default.
- W2971640557 cites W2138090246 @default.
- W2971640557 cites W2154694480 @default.
- W2971640557 cites W2157503340 @default.
- W2971640557 cites W2157586673 @default.
- W2971640557 cites W2162166699 @default.
- W2971640557 cites W2162762911 @default.
- W2971640557 cites W2166010463 @default.
- W2971640557 cites W2168346186 @default.
- W2971640557 cites W2171296186 @default.
- W2971640557 cites W2175913986 @default.
- W2971640557 cites W2236305531 @default.
- W2971640557 cites W2265707556 @default.
- W2971640557 cites W2279015277 @default.
- W2971640557 cites W2288121426 @default.
- W2971640557 cites W2296970428 @default.
- W2971640557 cites W2304304083 @default.
- W2971640557 cites W2307082067 @default.
- W2971640557 cites W2313673876 @default.
- W2971640557 cites W2320464738 @default.
- W2971640557 cites W2338157594 @default.
- W2971640557 cites W2484877107 @default.
- W2971640557 cites W2501949584 @default.
- W2971640557 cites W2511851700 @default.
- W2971640557 cites W2529603946 @default.
- W2971640557 cites W2564861511 @default.
- W2971640557 cites W2568023412 @default.
- W2971640557 cites W2582810525 @default.
- W2971640557 cites W2588025094 @default.
- W2971640557 cites W2606060101 @default.
- W2971640557 cites W2610210333 @default.
- W2971640557 cites W2617196371 @default.
- W2971640557 cites W2743911448 @default.
- W2971640557 cites W2750765400 @default.
- W2971640557 cites W2761769636 @default.
- W2971640557 cites W2767548359 @default.
- W2971640557 cites W2773117945 @default.
- W2971640557 cites W2778992824 @default.
- W2971640557 cites W2782875470 @default.
- W2971640557 cites W2795877587 @default.
- W2971640557 cites W2799843507 @default.
- W2971640557 cites W2806694951 @default.
- W2971640557 cites W2816825765 @default.
- W2971640557 cites W2888792319 @default.
- W2971640557 cites W2892197741 @default.
- W2971640557 cites W2901270606 @default.
- W2971640557 cites W2902935147 @default.
- W2971640557 cites W2909449194 @default.
- W2971640557 cites W2964224732 @default.
- W2971640557 cites W4244629450 @default.
- W2971640557 cites W4253796858 @default.
- W2971640557 doi "https://doi.org/10.3389/fimmu.2019.02217" @default.
- W2971640557 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6753331" @default.
- W2971640557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31572403" @default.
- W2971640557 hasPublicationYear "2019" @default.
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