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- W2971669237 abstract "Over the years, biocatalysis has been increasingly utilized to support different stages of pharmaceutical development, from safety and toxicological studies to development of commercial products. Directed evolution has played a major role in improving and imparting novel properties of biocatalysts, rendering them equivalent, or even superior, to their chemical counterparts. Using the CodeEvolver® protein engineering technology, Codexis has successfully engineered ketoreductases for reduction of ketones to generate chiral secondary alcohols, providing building blocks for the synthesis of a wide range of pharmaceutical products. Manufacturing processes incorporating these biocatalysts often have reduced the number of synthetic steps, produced less waste, and provided higher yield of the desired chiral alcohol." @default.
- W2971669237 created "2019-09-12" @default.
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- W2971669237 date "2019-04-29" @default.
- W2971669237 modified "2023-09-27" @default.
- W2971669237 title "KREDs: Toward Green, Cost-Effective, and Efficient Chiral Alcohol Generation" @default.
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- W2971669237 doi "https://doi.org/10.1002/9783527813780.ch5_1" @default.
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