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- W2971730877 abstract "ABSTRACT MicroRNAs (miRNAs) are ubiquitous small RNAs, which guide post-transcriptional gene repression in countless biological processes. However, the miRNA pathway in mouse oocytes appears inactive and is dispensable for development. We report that miRNAs do not accumulate like maternal mRNAs during oocyte growth. The most abundant miRNAs total tens of thousands of molecules in fully-grown oocytes, a number similar to that observed in much smaller fibroblasts. The lack of miRNA accumulation acts like miRNA knock-down, where miRNAs can engage their targets but are not abundant enough to produce significant silencing effect. Injection of 100,000 miRNAs was sufficient to restore reporter repression in oocytes, confirming that miRNA inactivity primarily stems from low miRNA abundance and not from an active repression of the miRNA pathway per se . Similar situation was observed in rat, hamster, porcine, and bovine oocytes arguing that miRNA inactivity is not a mouse-specific adaptation but a common mammalian oocyte feature." @default.
- W2971730877 created "2019-09-12" @default.
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- W2971730877 date "2019-09-06" @default.
- W2971730877 modified "2023-10-02" @default.
- W2971730877 title "Low miRNA abundance disables microRNA pathway in mammalian oocytes" @default.
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- W2971730877 doi "https://doi.org/10.1101/757153" @default.
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