FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2971756656> ?p ?o ?g. }

• W2971756656 abstract "3076 Background: Recent studies have identified molecular events characteristic of immunogenic cell death. These include surface exposure of calreticulin, HSP70 and HSP90, release of intranuclear HMGB1 and secretion of ATP from dying cells. Several chemotherapeutic agents, including anthracyclins, oxaliplatin and bortezomib, and hypericin-based photodynamic therapy have been described to induce the immunogenic cell death in human tumor cells. We investigated the potential of high hydrostatic pressure (HHP) to induce immunogenic cell death in human tumor cells. Methods: Prostate and ovarian cancer cell lines and primary tumor cells were treated by HHP and we analyzed the kinetics of the expression of immunogenic cell death markers. HHP killed tumor cells expressing immunogenic cell death markers were tested for their ability to activate dendritic cells (DCs), to induce tumor specific T cells and regulatory T cells. Results: HHP induced rapid expression of HSP70, HSP90 and calreticulin on the cell surface of all tested cell lines and primary tumor cells. HHP also induced release of HMGB1 and ATP from treated cells. The kinetics of expression was similar to doxorubicin, HHP, however, induced 1.5-2 fold higher expression of HSP70, HSP90 and calreticulin. The interaction of DCs with HHP-treated tumor cells led to the faster rate of phagocytosis, significant upregulation of CD83, CD86 and HLA-DR and release of IL-6, IL-12p70 and TNFα. The ability of HHP-killed tumor cells to promote DCs maturation was cell contact dependent. DCs pulsed with tumor cells killed by HHP induced high numbers of tumor-specific CD4 + and CD8 + IFN-g-producing T cells even in the absence of additional maturation stimulus. DCs pulsed with HHP treated tumor cells also induced the lowest number of regulatory T cells among the tested conditions. Cells treated by HHP can by cryopreserved in liquid nitrogen and retain their immunogenic properties upon thawing thus allowing for their convenient use in the manufacturing of cancer immunotherapy products. Conclusions: High hydrostatic pressure is a reliable and very potent inducer of immunogenic cell death in the wide range of human tumor cell lines and primary tumor cells." @default.
• W2971756656 created "2019-09-12" @default.
• W2971756656 creator A5011373942 @default.
• W2971756656 creator A5021206531 @default.
• W2971756656 creator A5021535985 @default.
• W2971756656 creator A5026488935 @default.
• W2971756656 creator A5033364191 @default.
• W2971756656 creator A5049805426 @default.
• W2971756656 date "2013-05-20" @default.
• W2971756656 modified "2023-09-23" @default.
• W2971756656 title "High hydrostatic pressure to induce immunogenic cell death in human tumor cells." @default.
• W2971756656 doi "https://doi.org/10.1200/jco.2013.31.15_suppl.3076" @default.
• W2971756656 hasPublicationYear "2013" @default.
• W2971756656 type Work @default.
• W2971756656 sameAs 2971756656 @default.
• W2971756656 citedByCount "0" @default.
• W2971756656 crossrefType "journal-article" @default.
• W2971756656 hasAuthorship W2971756656A5011373942 @default.
• W2971756656 hasAuthorship W2971756656A5021206531 @default.
• W2971756656 hasAuthorship W2971756656A5021535985 @default.
• W2971756656 hasAuthorship W2971756656A5026488935 @default.
• W2971756656 hasAuthorship W2971756656A5033364191 @default.
• W2971756656 hasAuthorship W2971756656A5049805426 @default.
• W2971756656 hasConcept C121332964 @default.
• W2971756656 hasConcept C190283241 @default.
• W2971756656 hasConcept C2910081258 @default.
• W2971756656 hasConcept C3020616263 @default.
• W2971756656 hasConcept C31573885 @default.
• W2971756656 hasConcept C502942594 @default.
• W2971756656 hasConcept C54355233 @default.
• W2971756656 hasConcept C71924100 @default.
• W2971756656 hasConcept C86803240 @default.
• W2971756656 hasConcept C97355855 @default.
• W2971756656 hasConceptScore W2971756656C121332964 @default.
• W2971756656 hasConceptScore W2971756656C190283241 @default.
• W2971756656 hasConceptScore W2971756656C2910081258 @default.
• W2971756656 hasConceptScore W2971756656C3020616263 @default.
• W2971756656 hasConceptScore W2971756656C31573885 @default.
• W2971756656 hasConceptScore W2971756656C502942594 @default.
• W2971756656 hasConceptScore W2971756656C54355233 @default.
• W2971756656 hasConceptScore W2971756656C71924100 @default.
• W2971756656 hasConceptScore W2971756656C86803240 @default.
• W2971756656 hasConceptScore W2971756656C97355855 @default.
• W2971756656 hasLocation W29717566561 @default.
• W2971756656 hasOpenAccess W2971756656 @default.
• W2971756656 hasPrimaryLocation W29717566561 @default.
• W2971756656 hasRelatedWork W1654985984 @default.
• W2971756656 hasRelatedWork W1974412246 @default.
• W2971756656 hasRelatedWork W1980400322 @default.
• W2971756656 hasRelatedWork W1997643195 @default.
• W2971756656 hasRelatedWork W2005488015 @default.
• W2971756656 hasRelatedWork W2047805526 @default.
• W2971756656 hasRelatedWork W2056692946 @default.
• W2971756656 hasRelatedWork W2064973017 @default.
• W2971756656 hasRelatedWork W2072980308 @default.
• W2971756656 hasRelatedWork W2088019765 @default.
• W2971756656 hasRelatedWork W2102053743 @default.
• W2971756656 hasRelatedWork W2108263396 @default.
• W2971756656 hasRelatedWork W2112226781 @default.
• W2971756656 hasRelatedWork W2138703422 @default.
• W2971756656 hasRelatedWork W2278488323 @default.
• W2971756656 hasRelatedWork W2470529533 @default.
• W2971756656 hasRelatedWork W2481669406 @default.
• W2971756656 hasRelatedWork W2579439234 @default.
• W2971756656 hasRelatedWork W2742384749 @default.
• W2971756656 hasRelatedWork W2765341345 @default.
• W2971756656 isParatext "false" @default.
• W2971756656 isRetracted "false" @default.
• W2971756656 magId "2971756656" @default.
• W2971756656 workType "article" @default.