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- W2971842132 abstract "Clinical administration of Interferon α (IFNα) resulted in limited therapeutic success against some viral infections. Immune modulation of CD8+ T cell responses during IFNα therapy is believed to play a pivotal role in promoting viral clearance. However, these clinical studies primarily focused on IFNα subtype 2. To date, the immunomodulatory roles of the remaining 10-13 IFNα subtypes remains poorly understood, thereby precluding assessments of their potential for more effective treatments. Here, we report that virus-specific CD8+ T cell responses were influenced to various extents by individual IFNα subtypes. IFNα4, 6, and 9 had the strongest effects on CD8+ T cells, including antiproliferative effects, improved cytokine production and cytotoxicity. Interestingly, augmented cytokine responses were dependent on IFNα subtype stimulation of dendritic cells (DCs), while antiproliferative effects and cytotoxicity were mediated by IFNAR signaling in either CD8+ T cells or DCs. Thus, precise modulation of virus-specific CD8+ T cell responses may be feasible for specific antiviral immunotherapies through careful selection and administration of individual IFNα subtypes." @default.
- W2971842132 created "2019-09-12" @default.
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- W2971842132 date "2019-09-24" @default.
- W2971842132 modified "2023-10-18" @default.
- W2971842132 title "Diverse Immunomodulatory Effects of Individual IFNα Subtypes on Virus-Specific CD8+ T Cell Responses" @default.
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- W2971842132 cites W1608778557 @default.
- W2971842132 cites W1642082766 @default.
- W2971842132 cites W1667435701 @default.
- W2971842132 cites W1904077044 @default.
- W2971842132 cites W1953974801 @default.
- W2971842132 cites W1964271390 @default.
- W2971842132 cites W1966060871 @default.
- W2971842132 cites W1967475015 @default.
- W2971842132 cites W1972503143 @default.
- W2971842132 cites W1974965278 @default.
- W2971842132 cites W1977904206 @default.
- W2971842132 cites W1980095859 @default.
- W2971842132 cites W1980215946 @default.
- W2971842132 cites W1981136135 @default.
- W2971842132 cites W1983951850 @default.
- W2971842132 cites W1985467327 @default.
- W2971842132 cites W1990869684 @default.
- W2971842132 cites W1997384271 @default.
- W2971842132 cites W1997388148 @default.
- W2971842132 cites W2004597368 @default.
- W2971842132 cites W2004829503 @default.
- W2971842132 cites W2005634497 @default.
- W2971842132 cites W2005955102 @default.
- W2971842132 cites W2008189691 @default.
- W2971842132 cites W2009905888 @default.
- W2971842132 cites W2011308270 @default.
- W2971842132 cites W2013039788 @default.
- W2971842132 cites W2013486480 @default.
- W2971842132 cites W2024556668 @default.
- W2971842132 cites W2026054459 @default.
- W2971842132 cites W2028638163 @default.
- W2971842132 cites W2029323175 @default.
- W2971842132 cites W2033856426 @default.
- W2971842132 cites W2038576929 @default.
- W2971842132 cites W2043519223 @default.
- W2971842132 cites W2044951291 @default.
- W2971842132 cites W2048513925 @default.
- W2971842132 cites W2049868800 @default.
- W2971842132 cites W2054111796 @default.
- W2971842132 cites W2062813847 @default.
- W2971842132 cites W2064555472 @default.
- W2971842132 cites W2066848741 @default.
- W2971842132 cites W2068046103 @default.
- W2971842132 cites W2070533971 @default.
- W2971842132 cites W2074640200 @default.
- W2971842132 cites W2075527727 @default.
- W2971842132 cites W2082926682 @default.
- W2971842132 cites W2087837555 @default.
- W2971842132 cites W2090001019 @default.
- W2971842132 cites W2093731559 @default.
- W2971842132 cites W2096372976 @default.
- W2971842132 cites W2098459535 @default.
- W2971842132 cites W2101910308 @default.
- W2971842132 cites W2107219546 @default.
- W2971842132 cites W2110932366 @default.
- W2971842132 cites W2111620963 @default.
- W2971842132 cites W2124969212 @default.
- W2971842132 cites W2137929296 @default.
- W2971842132 cites W2139175652 @default.
- W2971842132 cites W2150098469 @default.
- W2971842132 cites W2152095262 @default.
- W2971842132 cites W2167661882 @default.
- W2971842132 cites W2169063455 @default.
- W2971842132 cites W2177327503 @default.
- W2971842132 cites W2339763143 @default.
- W2971842132 cites W24266920 @default.
- W2971842132 cites W2560024983 @default.
- W2971842132 cites W2560256790 @default.
- W2971842132 cites W2586317281 @default.
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- W2971842132 doi "https://doi.org/10.3389/fimmu.2019.02255" @default.
- W2971842132 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6771563" @default.
- W2971842132 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31608062" @default.
- W2971842132 hasPublicationYear "2019" @default.
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