FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2971846774> ?p ?o ?g. }

• W2971846774 endingPage "91" @default.
• W2971846774 startingPage "78" @default.
• W2971846774 abstract "Abstract In June 2018, a 'research chemica'l labeled 'AB‐FUB7AICA' was purchased online and analytically identified as 5F‐AB‐P7AICA, the 7‐azaindole analog of 5F‐AB‐PINACA. Here we present data on structural characterization, suitable urinary consumption markers, and preliminary pharmacokinetic data. Structure characterization was performed by nuclear magnetic resonance spectroscopy, gas chromatography–mass spectrometry, infrared and Raman spectroscopy. Phase I metabolites were generated by applying a pooled human liver microsome assay (pHLM) to confirm the analysis results of authentic urine samples collected after oral self‐administration of 2.5 mg 5F‐AB‐P7AICA. Analyses of pHLM and urine samples were performed by liquid chromatography−time‐of‐flight mass spectrometry and liquid chromatography–tandem mass spectrometry (LC–MS/MS). An LC–MS/MS method for the quantification of 5F‐AB‐P7AICA in serum was validated. Ten phase I metabolites were detected in human urine samples and confirmed in vitro. The main metabolites were formed by hydroxylation, amide hydrolysis, and hydrolytic defluorination, though – in contrast with most other synthetic cannabinoids – the parent compound showed the highest signals in most urine samples. The compound detection window was more than 45 hours in serum. The concentration‐time profile was best explained by a two‐phase pharmacokinetic model. 5F‐AB‐P7AICA was detected in urine samples until 65 hours post ingestion. Monitoring of metabolite M07, hydroxylated at the alkyl chain, next to parent 5F‐AB‐P7AICA, is recommended to confirm the uptake of 5F‐AB‐P7AICA in urinalysis. It seems plausible that the shift of the nitrogen atom from position 2 to 7 (e.g. 5F‐AB‐PINACA to 5F‐AB‐P7AICA) leads to a lower metabolic reactivity, which might be of general interest in medicinal chemistry." @default.
• W2971846774 created "2019-09-12" @default.
• W2971846774 creator A5004340821 @default.
• W2971846774 creator A5007260575 @default.
• W2971846774 creator A5020913660 @default.
• W2971846774 creator A5023065580 @default.
• W2971846774 creator A5030841627 @default.
• W2971846774 creator A5031749726 @default.
• W2971846774 creator A5040440723 @default.
• W2971846774 creator A5064596365 @default.
• W2971846774 creator A5080134092 @default.
• W2971846774 creator A5087885664 @default.
• W2971846774 date "2019-10-23" @default.
• W2971846774 modified "2023-09-26" @default.
• W2971846774 title "Detection and phase I metabolism of the 7‐azaindole‐derived synthetic cannabinoid 5F‐AB‐P7AICA including a preliminary pharmacokinetic evaluation" @default.
• W2971846774 cites W1536445278 @default.
• W2971846774 cites W1855306715 @default.
• W2971846774 cites W1897401880 @default.
• W2971846774 cites W1899851239 @default.
• W2971846774 cites W1916493178 @default.
• W2971846774 cites W1967595833 @default.
• W2971846774 cites W1970083550 @default.
• W2971846774 cites W1971590308 @default.
• W2971846774 cites W1976981359 @default.
• W2971846774 cites W1982611995 @default.
• W2971846774 cites W1986904152 @default.
• W2971846774 cites W1992153005 @default.
• W2971846774 cites W2024053795 @default.
• W2971846774 cites W2048921576 @default.
• W2971846774 cites W2050226999 @default.
• W2971846774 cites W2070099706 @default.
• W2971846774 cites W2077881848 @default.
• W2971846774 cites W2078844130 @default.
• W2971846774 cites W2097899946 @default.
• W2971846774 cites W2102117682 @default.
• W2971846774 cites W2169754532 @default.
• W2971846774 cites W2290232152 @default.
• W2971846774 cites W2306386326 @default.
• W2971846774 cites W2309967278 @default.
• W2971846774 cites W2492836649 @default.
• W2971846774 cites W2583800955 @default.
• W2971846774 cites W2595397629 @default.
• W2971846774 cites W2604497858 @default.
• W2971846774 cites W2617853301 @default.
• W2971846774 cites W2763616685 @default.
• W2971846774 cites W2801605997 @default.
• W2971846774 cites W2885190487 @default.
• W2971846774 cites W2889124841 @default.
• W2971846774 cites W2889385741 @default.
• W2971846774 cites W2894187766 @default.
• W2971846774 cites W2894799643 @default.
• W2971846774 cites W2904834968 @default.
• W2971846774 cites W2907342720 @default.
• W2971846774 cites W2910406707 @default.
• W2971846774 doi "https://doi.org/10.1002/dta.2692" @default.
• W2971846774 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31476105" @default.
• W2971846774 hasPublicationYear "2019" @default.
• W2971846774 type Work @default.
• W2971846774 sameAs 2971846774 @default.
• W2971846774 citedByCount "17" @default.
• W2971846774 countsByYear W29718467742020 @default.
• W2971846774 countsByYear W29718467742021 @default.
• W2971846774 countsByYear W29718467742022 @default.
• W2971846774 countsByYear W29718467742023 @default.
• W2971846774 crossrefType "journal-article" @default.
• W2971846774 hasAuthorship W2971846774A5004340821 @default.
• W2971846774 hasAuthorship W2971846774A5007260575 @default.
• W2971846774 hasAuthorship W2971846774A5020913660 @default.
• W2971846774 hasAuthorship W2971846774A5023065580 @default.
• W2971846774 hasAuthorship W2971846774A5030841627 @default.
• W2971846774 hasAuthorship W2971846774A5031749726 @default.
• W2971846774 hasAuthorship W2971846774A5040440723 @default.
• W2971846774 hasAuthorship W2971846774A5064596365 @default.
• W2971846774 hasAuthorship W2971846774A5080134092 @default.
• W2971846774 hasAuthorship W2971846774A5087885664 @default.
• W2971846774 hasBestOaLocation W29718467741 @default.
• W2971846774 hasConcept C112705442 @default.
• W2971846774 hasConcept C162356407 @default.
• W2971846774 hasConcept C170493617 @default.
• W2971846774 hasConcept C181199279 @default.
• W2971846774 hasConcept C185592680 @default.
• W2971846774 hasConcept C2777477808 @default.
• W2971846774 hasConcept C2777846614 @default.
• W2971846774 hasConcept C2779225474 @default.
• W2971846774 hasConcept C2780026642 @default.
• W2971846774 hasConcept C2780871563 @default.
• W2971846774 hasConcept C2781109383 @default.
• W2971846774 hasConcept C31827203 @default.
• W2971846774 hasConcept C43617362 @default.
• W2971846774 hasConcept C55493867 @default.
• W2971846774 hasConcept C64489805 @default.
• W2971846774 hasConcept C71924100 @default.
• W2971846774 hasConcept C98274493 @default.
• W2971846774 hasConceptScore W2971846774C112705442 @default.
• W2971846774 hasConceptScore W2971846774C162356407 @default.
• W2971846774 hasConceptScore W2971846774C170493617 @default.
• W2971846774 hasConceptScore W2971846774C181199279 @default.
• W2971846774 hasConceptScore W2971846774C185592680 @default.

• next