Matches in SemOpenAlex for { <https://semopenalex.org/work/W2971888738> ?p ?o ?g. }
- W2971888738 endingPage "1449" @default.
- W2971888738 startingPage "1437" @default.
- W2971888738 abstract "Aim: Fragment crystallizable (Fc) glycosylation of immunoglobulin G-type monoclonal antibodies applied to therapeutic applications is regarded a critical quality attribute and can influence bioactivity, pharmacokinetics and/or immunogenicity/safety. Investigating the impact of certain Fc N-glycans is therefore of importance to assess its criticality for a therapeutic product. This has been done for N-glycan types like fucosylation, galactosylation or sialylation. There were contradictory results reported for functionality especially with regard to sialylation. Material & methods: We elucidated the effect of terminal sialic acid residues on Fcγ receptor binding and antibody dependent cytotoxicity activity of two immunoglobulin G1 antibodies with different levels of fucosylation/bi-secting. Conclusion: We found the impact to be specific to the sialylation linkage type, in other words, α2,3- versus α2,6-linked sialic acid attached to the terminal galactose residues" @default.
- W2971888738 created "2019-09-12" @default.
- W2971888738 creator A5005323074 @default.
- W2971888738 creator A5030047305 @default.
- W2971888738 creator A5037847782 @default.
- W2971888738 creator A5039647294 @default.
- W2971888738 creator A5052656493 @default.
- W2971888738 creator A5057185119 @default.
- W2971888738 creator A5066009283 @default.
- W2971888738 creator A5080627763 @default.
- W2971888738 creator A5091277509 @default.
- W2971888738 date "2019-08-01" @default.
- W2971888738 modified "2023-10-01" @default.
- W2971888738 title "Effects of sialic acid linkage on antibody-fragment crystallizable receptor binding and antibody dependent cytotoxicity depend on levels of fucosylation/bisecting" @default.
- W2971888738 cites W1049877765 @default.
- W2971888738 cites W1191527629 @default.
- W2971888738 cites W1529809181 @default.
- W2971888738 cites W1532698890 @default.
- W2971888738 cites W1908224577 @default.
- W2971888738 cites W1969824500 @default.
- W2971888738 cites W1975345897 @default.
- W2971888738 cites W1978471536 @default.
- W2971888738 cites W1985707736 @default.
- W2971888738 cites W1988112437 @default.
- W2971888738 cites W2015723482 @default.
- W2971888738 cites W2035433348 @default.
- W2971888738 cites W2035753258 @default.
- W2971888738 cites W2044791218 @default.
- W2971888738 cites W2049743251 @default.
- W2971888738 cites W2051666192 @default.
- W2971888738 cites W2067367025 @default.
- W2971888738 cites W2076731564 @default.
- W2971888738 cites W2135477962 @default.
- W2971888738 cites W2288642608 @default.
- W2971888738 cites W2302489180 @default.
- W2971888738 cites W2325475319 @default.
- W2971888738 cites W2404054284 @default.
- W2971888738 cites W2478409189 @default.
- W2971888738 cites W2596270747 @default.
- W2971888738 cites W2734847489 @default.
- W2971888738 cites W2741734362 @default.
- W2971888738 cites W2763279828 @default.
- W2971888738 cites W2768717631 @default.
- W2971888738 cites W2795673785 @default.
- W2971888738 cites W2936372844 @default.
- W2971888738 cites W2952085518 @default.
- W2971888738 cites W848361005 @default.
- W2971888738 doi "https://doi.org/10.4155/bio-2019-0124" @default.
- W2971888738 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31490109" @default.
- W2971888738 hasPublicationYear "2019" @default.
- W2971888738 type Work @default.
- W2971888738 sameAs 2971888738 @default.
- W2971888738 citedByCount "11" @default.
- W2971888738 countsByYear W29718887382019 @default.
- W2971888738 countsByYear W29718887382020 @default.
- W2971888738 countsByYear W29718887382021 @default.
- W2971888738 countsByYear W29718887382022 @default.
- W2971888738 countsByYear W29718887382023 @default.
- W2971888738 crossrefType "journal-article" @default.
- W2971888738 hasAuthorship W2971888738A5005323074 @default.
- W2971888738 hasAuthorship W2971888738A5030047305 @default.
- W2971888738 hasAuthorship W2971888738A5037847782 @default.
- W2971888738 hasAuthorship W2971888738A5039647294 @default.
- W2971888738 hasAuthorship W2971888738A5052656493 @default.
- W2971888738 hasAuthorship W2971888738A5057185119 @default.
- W2971888738 hasAuthorship W2971888738A5066009283 @default.
- W2971888738 hasAuthorship W2971888738A5080627763 @default.
- W2971888738 hasAuthorship W2971888738A5091277509 @default.
- W2971888738 hasConcept C108625454 @default.
- W2971888738 hasConcept C109316439 @default.
- W2971888738 hasConcept C125823703 @default.
- W2971888738 hasConcept C153911025 @default.
- W2971888738 hasConcept C159654299 @default.
- W2971888738 hasConcept C170493617 @default.
- W2971888738 hasConcept C185592680 @default.
- W2971888738 hasConcept C202751555 @default.
- W2971888738 hasConcept C203014093 @default.
- W2971888738 hasConcept C206212055 @default.
- W2971888738 hasConcept C2777313579 @default.
- W2971888738 hasConcept C2779212266 @default.
- W2971888738 hasConcept C2779931124 @default.
- W2971888738 hasConcept C2780115458 @default.
- W2971888738 hasConcept C2780868878 @default.
- W2971888738 hasConcept C2780898057 @default.
- W2971888738 hasConcept C542903549 @default.
- W2971888738 hasConcept C55493867 @default.
- W2971888738 hasConcept C86803240 @default.
- W2971888738 hasConceptScore W2971888738C108625454 @default.
- W2971888738 hasConceptScore W2971888738C109316439 @default.
- W2971888738 hasConceptScore W2971888738C125823703 @default.
- W2971888738 hasConceptScore W2971888738C153911025 @default.
- W2971888738 hasConceptScore W2971888738C159654299 @default.
- W2971888738 hasConceptScore W2971888738C170493617 @default.
- W2971888738 hasConceptScore W2971888738C185592680 @default.
- W2971888738 hasConceptScore W2971888738C202751555 @default.
- W2971888738 hasConceptScore W2971888738C203014093 @default.
- W2971888738 hasConceptScore W2971888738C206212055 @default.
- W2971888738 hasConceptScore W2971888738C2777313579 @default.