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• W2971915501 abstract "Significance Liver has a remarkable regenerative capacity following injuries. However, the cellular dynamics of how hepatocytes are replenished during homeostasis and upon liver injuries remains largely unclear. By using genetic lineage tracing strategies on rare Lgr5 + hepatocytes surrounding the central veins of the liver lobule, this study shows that Lgr5 + hepatocytes are self-maintained during normal homeostasis and various liver injuries, and contributed to hepatocarcinogesis in two different hepatocellular carcinoma (HCC) models. Our findings provide an insight on hepatocyte regeneration under homeostasis and liver injuries and uncover Lgr5 + hepatocytes as potential cellular origin in HCC development." @default.
• W2971915501 created "2019-09-12" @default.
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• W2971915501 date "2019-09-05" @default.
• W2971915501 modified "2023-10-12" @default.
• W2971915501 title "Lgr5 ⁺ pericentral hepatocytes are self-maintained in normal liver regeneration and susceptible to hepatocarcinogenesis" @default.
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• W2971915501 doi "https://doi.org/10.1073/pnas.1908099116" @default.
• W2971915501 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6765306" @default.
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• W2971915501 hasPublicationYear "2019" @default.
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