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• W2971947783 abstract "A new synthesis of isoindolinones was discovered during a screening campaign aimed at the development of novel methods for the synthesis of pyridone-EZH2 inhibitor analogues. The reaction proceeds via an intramolecular [4+2] cycloaddition of a pyridone with a tethered propiolamide moiety followed by extrusion of isocyanic acid. The discovery, optimization, and scope of the methodology are described." @default.
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• W2971947783 date "2019-10-01" @default.
• W2971947783 modified "2023-09-29" @default.
• W2971947783 title "Synthesis of isoindolinones: Intramolecular [4+2] cycloaddition/retro [4+2] of pyridone propiolamides" @default.
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• W2971947783 doi "https://doi.org/10.1016/j.tetlet.2019.151105" @default.
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