Matches in SemOpenAlex for { <https://semopenalex.org/work/W2971986391> ?p ?o ?g. }
- W2971986391 endingPage "145" @default.
- W2971986391 startingPage "138" @default.
- W2971986391 abstract "The GMALL07/2003 protocol introduced pegylated E. coli asparaginase (PEG-ASNase) frontline for adults with acute lymphoblastic leukemia (ALL). PEG-ASNase (500 U/m2, 1000 U/m2, or 2000 U/m2) was given once in induction and as part of three HD-MTX/PEG-ASNase cycles with two PEG-ASNase doses every other week in consolidation. PEG-ASNase activities were monitored in 1363 serum samples from 304 ALL patients. The overall rate of silent inactivation was low (5%) and did not differ between induction and consolidation. The successful targeting of PEG-ASNase activities ≥100 U/L depended on protocol and dose. Overall PEG-ASNase activities were higher during consolidation compared to induction. To target PEG-ASNase activities ≥100 U/L for 14 day with a single dose in induction, 2000 U/m2 was more preferable than 1000 U/m2 or 500 U/m2. During consolidation with two administrations every other week, 1000 U/m2 and 2000 U/m2 were similarly effective in sustaining PEG-ASNase ≥100 U/L activities over 14 days." @default.
- W2971986391 created "2019-09-12" @default.
- W2971986391 creator A5017446958 @default.
- W2971986391 creator A5031716236 @default.
- W2971986391 creator A5034762807 @default.
- W2971986391 creator A5037414415 @default.
- W2971986391 creator A5039019818 @default.
- W2971986391 creator A5040029107 @default.
- W2971986391 creator A5044138253 @default.
- W2971986391 creator A5054064406 @default.
- W2971986391 creator A5059188766 @default.
- W2971986391 creator A5066213019 @default.
- W2971986391 creator A5067318724 @default.
- W2971986391 creator A5069712978 @default.
- W2971986391 date "2019-09-03" @default.
- W2971986391 modified "2023-09-30" @default.
- W2971986391 title "Asparaginase activities during intensified treatment with pegylated <i>E. coli</i> asparaginase in adults with newly-diagnosed acute lymphoblastic leukemia" @default.
- W2971986391 cites W1944430150 @default.
- W2971986391 cites W1966763079 @default.
- W2971986391 cites W1971341070 @default.
- W2971986391 cites W1978602215 @default.
- W2971986391 cites W1988623079 @default.
- W2971986391 cites W2000173878 @default.
- W2971986391 cites W2005688611 @default.
- W2971986391 cites W2010002712 @default.
- W2971986391 cites W2010729137 @default.
- W2971986391 cites W2017265604 @default.
- W2971986391 cites W2024893955 @default.
- W2971986391 cites W2025671957 @default.
- W2971986391 cites W2053754416 @default.
- W2971986391 cites W2053852136 @default.
- W2971986391 cites W2056667876 @default.
- W2971986391 cites W2065158892 @default.
- W2971986391 cites W2080828049 @default.
- W2971986391 cites W2103347449 @default.
- W2971986391 cites W2106275447 @default.
- W2971986391 cites W2111432042 @default.
- W2971986391 cites W2113512182 @default.
- W2971986391 cites W2116861668 @default.
- W2971986391 cites W2123822349 @default.
- W2971986391 cites W2129291628 @default.
- W2971986391 cites W2131521161 @default.
- W2971986391 cites W2144921015 @default.
- W2971986391 cites W2145357113 @default.
- W2971986391 cites W2146762986 @default.
- W2971986391 cites W2156840245 @default.
- W2971986391 cites W2163219205 @default.
- W2971986391 cites W2169732420 @default.
- W2971986391 cites W2292251821 @default.
- W2971986391 cites W2342690981 @default.
- W2971986391 cites W2485785171 @default.
- W2971986391 cites W2490927833 @default.
- W2971986391 cites W2603315774 @default.
- W2971986391 cites W2727803568 @default.
- W2971986391 cites W2788285407 @default.
- W2971986391 cites W2902840650 @default.
- W2971986391 cites W2939150686 @default.
- W2971986391 cites W2945356250 @default.
- W2971986391 cites W426270985 @default.
- W2971986391 doi "https://doi.org/10.1080/10428194.2019.1658099" @default.
- W2971986391 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31480965" @default.
- W2971986391 hasPublicationYear "2019" @default.
- W2971986391 type Work @default.
- W2971986391 sameAs 2971986391 @default.
- W2971986391 citedByCount "16" @default.
- W2971986391 countsByYear W29719863912019 @default.
- W2971986391 countsByYear W29719863912020 @default.
- W2971986391 countsByYear W29719863912021 @default.
- W2971986391 countsByYear W29719863912022 @default.
- W2971986391 countsByYear W29719863912023 @default.
- W2971986391 crossrefType "journal-article" @default.
- W2971986391 hasAuthorship W2971986391A5017446958 @default.
- W2971986391 hasAuthorship W2971986391A5031716236 @default.
- W2971986391 hasAuthorship W2971986391A5034762807 @default.
- W2971986391 hasAuthorship W2971986391A5037414415 @default.
- W2971986391 hasAuthorship W2971986391A5039019818 @default.
- W2971986391 hasAuthorship W2971986391A5040029107 @default.
- W2971986391 hasAuthorship W2971986391A5044138253 @default.
- W2971986391 hasAuthorship W2971986391A5054064406 @default.
- W2971986391 hasAuthorship W2971986391A5059188766 @default.
- W2971986391 hasAuthorship W2971986391A5066213019 @default.
- W2971986391 hasAuthorship W2971986391A5067318724 @default.
- W2971986391 hasAuthorship W2971986391A5069712978 @default.
- W2971986391 hasConcept C10138342 @default.
- W2971986391 hasConcept C121955636 @default.
- W2971986391 hasConcept C126322002 @default.
- W2971986391 hasConcept C144133560 @default.
- W2971986391 hasConcept C162324750 @default.
- W2971986391 hasConcept C2776014549 @default.
- W2971986391 hasConcept C2778461978 @default.
- W2971986391 hasConcept C2778904437 @default.
- W2971986391 hasConcept C2779149719 @default.
- W2971986391 hasConcept C2909962599 @default.
- W2971986391 hasConcept C54400483 @default.
- W2971986391 hasConcept C71924100 @default.
- W2971986391 hasConcept C98274493 @default.
- W2971986391 hasConceptScore W2971986391C10138342 @default.
- W2971986391 hasConceptScore W2971986391C121955636 @default.