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- W2972003706 endingPage "2097" @default.
- W2972003706 startingPage "2081" @default.
- W2972003706 abstract "Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. Scientists have not successfully developed drugs that target KRAS, although efforts have been made last three decades. In this review, we highlight the emerging experimental strategies of impairing KRAS membrane localization and the direct targeting of KRAS. We also conclude the combinatorial therapies and RNA interference technology for the treatment of KRAS mutant cancers. Moreover, the virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail." @default.
- W2972003706 created "2019-09-12" @default.
- W2972003706 creator A5054937803 @default.
- W2972003706 creator A5060817278 @default.
- W2972003706 creator A5076066661 @default.
- W2972003706 creator A5088617130 @default.
- W2972003706 date "2019-11-15" @default.
- W2972003706 modified "2023-09-26" @default.
- W2972003706 title "KRAS: A Promising Therapeutic Target for Cancer Treatment" @default.
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