FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2972048283> ?p ?o ?g. }

• W2972048283 abstract "Objective. Macrophage Migration Inhibitory Factor (MIF) is involved in the pathogenesis of systemic lupus erythematosus (SLE) and lupus nephritis(LN). MicroRNAs (miRNAs) play important roles in LN but whether specific miRNAs regulate the expression of MIF in LN is unknown. We explore specific miRNAs that can regulate MIF expression, and investigate miR-654 for the treatment of experimentally-induced murine lupus nephritis. Methods. Sera samples from 24 SLE patients and 24 controls were collected to measure MIF level, and its correlation with disease activity. Luciferase reporter assay was used to explore the target of miR-654. ELISA was used to detect the downstream cytokines regulated by miR-654 and MIF. Western blot was applied to measure the impact of miR-654 inhibition on downstream MIF signaling. The therapeutic efficacy of miR-654 was tested in the pristine induced lupus mouse model. We further measured miR-654 expression and analyzed its relationship with MIF expression in SLE patients. Results. Serum MIF level was increased in SLE patients (p<0. 001), positively correlated to SLEDAI score (r=0. 6348; p=0. 0009). MiR-654 inhibited MIF and downstream inflammatory cytokine production by selectively inhibiting the phosphorylation of ERK and AKT. Activation of miR-654 reduced IL-1β, IL-6, IL-8 and TNF-α production, relieved glomerulonephritis, and decreased MIF, IgG, and C3 expressions in murine lupus glomeruli. Furthermore, MIF was negatively correlated with miR-654 expression (r=-0. 5787; p=0. 0031) in SLE patients. Conclusion. MiR-654 negatively correlated with MIF and disease activity in patients with SLE. MiR-654 inhibits MIF expression via binding to MIF 3’UTR, selectively suppresses the phosphorylation of ERK and AKT, and reduces downstream inflammatory cytokine production. In vivo miR-654 treatment decreases MIF and downstream cytokine production and ameliorates murine lupus nephritis." @default.
• W2972048283 created "2019-09-12" @default.
• W2972048283 creator A5005480452 @default.
• W2972048283 creator A5008065494 @default.
• W2972048283 creator A5020928977 @default.
• W2972048283 creator A5028253934 @default.
• W2972048283 creator A5029495041 @default.
• W2972048283 creator A5047460101 @default.
• W2972048283 creator A5048079463 @default.
• W2972048283 creator A5053308237 @default.
• W2972048283 date "2019-09-19" @default.
• W2972048283 modified "2023-10-16" @default.
• W2972048283 title "MiRNA Regulation of MIF in SLE and Attenuation of Murine Lupus Nephritis With miR-654" @default.
• W2972048283 cites W144423133 @default.
• W2972048283 cites W1971944674 @default.
• W2972048283 cites W1989832114 @default.
• W2972048283 cites W1998484183 @default.
• W2972048283 cites W1998634876 @default.
• W2972048283 cites W2013282142 @default.
• W2972048283 cites W2014778624 @default.
• W2972048283 cites W2023917813 @default.
• W2972048283 cites W2040336985 @default.
• W2972048283 cites W2041840384 @default.
• W2972048283 cites W2064999867 @default.
• W2972048283 cites W2090056328 @default.
• W2972048283 cites W2096388504 @default.
• W2972048283 cites W2099896833 @default.
• W2972048283 cites W2109836805 @default.
• W2972048283 cites W2124973240 @default.
• W2972048283 cites W2126600660 @default.
• W2972048283 cites W2128048963 @default.
• W2972048283 cites W2132986108 @default.
• W2972048283 cites W2145979480 @default.
• W2972048283 cites W2146203649 @default.
• W2972048283 cites W2161048718 @default.
• W2972048283 cites W2187762512 @default.
• W2972048283 cites W2305553611 @default.
• W2972048283 cites W2332759606 @default.
• W2972048283 cites W2470228687 @default.
• W2972048283 cites W2500783422 @default.
• W2972048283 cites W2518920635 @default.
• W2972048283 cites W2524344698 @default.
• W2972048283 cites W2550125338 @default.
• W2972048283 cites W2551404503 @default.
• W2972048283 cites W2733476948 @default.
• W2972048283 cites W2797370960 @default.
• W2972048283 cites W2804904325 @default.
• W2972048283 cites W2911393991 @default.
• W2972048283 cites W818847790 @default.
• W2972048283 doi "https://doi.org/10.3389/fimmu.2019.02229" @default.
• W2972048283 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6761280" @default.
• W2972048283 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31608058" @default.
• W2972048283 hasPublicationYear "2019" @default.
• W2972048283 type Work @default.
• W2972048283 sameAs 2972048283 @default.
• W2972048283 citedByCount "33" @default.
• W2972048283 countsByYear W29720482832020 @default.
• W2972048283 countsByYear W29720482832021 @default.
• W2972048283 countsByYear W29720482832022 @default.
• W2972048283 countsByYear W29720482832023 @default.
• W2972048283 crossrefType "journal-article" @default.
• W2972048283 hasAuthorship W2972048283A5005480452 @default.
• W2972048283 hasAuthorship W2972048283A5008065494 @default.
• W2972048283 hasAuthorship W2972048283A5020928977 @default.
• W2972048283 hasAuthorship W2972048283A5028253934 @default.
• W2972048283 hasAuthorship W2972048283A5029495041 @default.
• W2972048283 hasAuthorship W2972048283A5047460101 @default.
• W2972048283 hasAuthorship W2972048283A5048079463 @default.
• W2972048283 hasAuthorship W2972048283A5053308237 @default.
• W2972048283 hasBestOaLocation W29720482831 @default.
• W2972048283 hasConcept C104177226 @default.
• W2972048283 hasConcept C104317684 @default.
• W2972048283 hasConcept C126322002 @default.
• W2972048283 hasConcept C145059251 @default.
• W2972048283 hasConcept C203014093 @default.
• W2972048283 hasConcept C2776415932 @default.
• W2972048283 hasConcept C2776912625 @default.
• W2972048283 hasConcept C2777058396 @default.
• W2972048283 hasConcept C2778690821 @default.
• W2972048283 hasConcept C2779134260 @default.
• W2972048283 hasConcept C2779912601 @default.
• W2972048283 hasConcept C2780942790 @default.
• W2972048283 hasConcept C55493867 @default.
• W2972048283 hasConcept C57074206 @default.
• W2972048283 hasConcept C62478195 @default.
• W2972048283 hasConcept C71924100 @default.
• W2972048283 hasConcept C86803240 @default.
• W2972048283 hasConcept C95444343 @default.
• W2972048283 hasConceptScore W2972048283C104177226 @default.
• W2972048283 hasConceptScore W2972048283C104317684 @default.
• W2972048283 hasConceptScore W2972048283C126322002 @default.
• W2972048283 hasConceptScore W2972048283C145059251 @default.
• W2972048283 hasConceptScore W2972048283C203014093 @default.
• W2972048283 hasConceptScore W2972048283C2776415932 @default.
• W2972048283 hasConceptScore W2972048283C2776912625 @default.
• W2972048283 hasConceptScore W2972048283C2777058396 @default.
• W2972048283 hasConceptScore W2972048283C2778690821 @default.
• W2972048283 hasConceptScore W2972048283C2779134260 @default.
• W2972048283 hasConceptScore W2972048283C2779912601 @default.
• W2972048283 hasConceptScore W2972048283C2780942790 @default.

• next