FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2972059080> ?p ?o ?g. }

• W2972059080 abstract "Pseudomonas aeruginosa (PA) is the leading cause of corneal blindness worldwide. A constant increase in multi-drug resistant PA strains have heightened the challenge of effectively managing corneal infections with conventional antibiotics. Antimicrobial peptides are promising antibiotic analogs with a unique mode of action. Cathelicidin-derived shorter peptides (FK13 and FK16) have previously been shown to kill a range of pathogens in both in vitro and in vivo systems. Here, our aim was to exploit the potential of FK13 or FK16 to enhance the anti-Pseudomonas activity of vancomycin, which normally has low clinical efficacy against PA. Our results have demonstrated that FK16 is more potent than FK13 against different PA strains including a clinical isolate from a patient's ocular surface. FK16 was shown to enhance the membrane permeability of PAO1 at sub-inhibitory concentrations. Moreover, FK16 at lower concentrations was shown to increase the antibacterial susceptibility of vancomycin against PA strains up to eightfold. The bactericidal synergism between FK16 and vancomycin was shown to be stable in the presence of physiological tear salt concentration and did not cause toxic effects on the human corneal epithelial cells and human red blood cells. Our results have revealed that sub-inhibitory concentration of FK16 could augment the antimicrobial effects of vancomycin against PA. It is anticipated that the future exploitation of the peptide design approach may enhance the effectiveness of FK16 and its application as an adjuvant to antibiotic therapy for the treatment of multi-drug resistant infections." @default.
• W2972059080 created "2019-09-12" @default.
• W2972059080 creator A5010294522 @default.
• W2972059080 creator A5019498420 @default.
• W2972059080 creator A5022866442 @default.
• W2972059080 creator A5027363095 @default.
• W2972059080 creator A5069736552 @default.
• W2972059080 date "2019-09-19" @default.
• W2972059080 modified "2023-10-16" @default.
• W2972059080 title "Cathelicidin-Derived Synthetic Peptide Improves Therapeutic Potential of Vancomycin Against Pseudomonas aeruginosa" @default.
• W2972059080 cites W1531296847 @default.
• W2972059080 cites W1665822623 @default.
• W2972059080 cites W1712936277 @default.
• W2972059080 cites W1969711244 @default.
• W2972059080 cites W1979973356 @default.
• W2972059080 cites W1982945317 @default.
• W2972059080 cites W1983174976 @default.
• W2972059080 cites W2010956829 @default.
• W2972059080 cites W2012472444 @default.
• W2972059080 cites W2037178359 @default.
• W2972059080 cites W2047580124 @default.
• W2972059080 cites W2054644778 @default.
• W2972059080 cites W2057418340 @default.
• W2972059080 cites W2059521816 @default.
• W2972059080 cites W2065361083 @default.
• W2972059080 cites W2075088552 @default.
• W2972059080 cites W2082057885 @default.
• W2972059080 cites W2084878620 @default.
• W2972059080 cites W2088155937 @default.
• W2972059080 cites W2109908798 @default.
• W2972059080 cites W2119078694 @default.
• W2972059080 cites W2121949549 @default.
• W2972059080 cites W2125765942 @default.
• W2972059080 cites W2135075666 @default.
• W2972059080 cites W2138464868 @default.
• W2972059080 cites W2140353364 @default.
• W2972059080 cites W2144048606 @default.
• W2972059080 cites W2144286887 @default.
• W2972059080 cites W2156473891 @default.
• W2972059080 cites W2216895045 @default.
• W2972059080 cites W2279841189 @default.
• W2972059080 cites W2288859094 @default.
• W2972059080 cites W2339844999 @default.
• W2972059080 cites W2340757114 @default.
• W2972059080 cites W2564165308 @default.
• W2972059080 cites W2586010661 @default.
• W2972059080 cites W2593444269 @default.
• W2972059080 cites W2597828438 @default.
• W2972059080 cites W2608835695 @default.
• W2972059080 cites W2621208977 @default.
• W2972059080 cites W2733026856 @default.
• W2972059080 cites W2757444754 @default.
• W2972059080 cites W2758716503 @default.
• W2972059080 cites W2788928684 @default.
• W2972059080 cites W2790069031 @default.
• W2972059080 cites W2791036254 @default.
• W2972059080 cites W2794891594 @default.
• W2972059080 cites W2802540740 @default.
• W2972059080 cites W2804562858 @default.
• W2972059080 cites W2809372875 @default.
• W2972059080 cites W2884114264 @default.
• W2972059080 cites W2886776390 @default.
• W2972059080 cites W2897764943 @default.
• W2972059080 cites W2898577604 @default.
• W2972059080 cites W2898667758 @default.
• W2972059080 cites W2904123526 @default.
• W2972059080 cites W2914213905 @default.
• W2972059080 doi "https://doi.org/10.3389/fmicb.2019.02190" @default.
• W2972059080 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6761703" @default.
• W2972059080 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31608030" @default.
• W2972059080 hasPublicationYear "2019" @default.
• W2972059080 type Work @default.
• W2972059080 sameAs 2972059080 @default.
• W2972059080 citedByCount "31" @default.
• W2972059080 countsByYear W29720590802020 @default.
• W2972059080 countsByYear W29720590802021 @default.
• W2972059080 countsByYear W29720590802022 @default.
• W2972059080 countsByYear W29720590802023 @default.
• W2972059080 crossrefType "journal-article" @default.
• W2972059080 hasAuthorship W2972059080A5010294522 @default.
• W2972059080 hasAuthorship W2972059080A5019498420 @default.
• W2972059080 hasAuthorship W2972059080A5022866442 @default.
• W2972059080 hasAuthorship W2972059080A5027363095 @default.
• W2972059080 hasAuthorship W2972059080A5069736552 @default.
• W2972059080 hasBestOaLocation W29720590801 @default.
• W2972059080 hasConcept C150903083 @default.
• W2972059080 hasConcept C176947019 @default.
• W2972059080 hasConcept C185592680 @default.
• W2972059080 hasConcept C207001950 @default.
• W2972059080 hasConcept C2775832221 @default.
• W2972059080 hasConcept C2777379352 @default.
• W2972059080 hasConcept C2777637488 @default.
• W2972059080 hasConcept C2778974779 @default.
• W2972059080 hasConcept C2778980435 @default.
• W2972059080 hasConcept C2779489039 @default.
• W2972059080 hasConcept C4937899 @default.
• W2972059080 hasConcept C501593827 @default.
• W2972059080 hasConcept C523546767 @default.
• W2972059080 hasConcept C540938839 @default.
• W2972059080 hasConcept C54355233 @default.

• next