Matches in SemOpenAlex for { <https://semopenalex.org/work/W2972068110> ?p ?o ?g. }
- W2972068110 endingPage "134236" @default.
- W2972068110 startingPage "134236" @default.
- W2972068110 abstract "The widespread emergence of antibiotic resistance genes (ARGs) in drinking water systems endangers human health, and may be exacerbated by their horizontal gene transfer (HGT) among microbiota. In our previous study, Quorum sensing (QS) molecules produced by bacteria from biological activated carbon (BAC) biofilms were demonstrated to influence the transfer efficiency of a model conjugative plasmid, here RP4. In this study, we further explored the effect and mechanism of QS on conjugation transfer. The results revealed that Acyl-homoserine lactones producing (AHL-producing) bacteria isolated from BAC biofilm play a role in the propagation of ARGs. We selected several quorum sensing inhibitors (QSIs) to study their effects on AHL-producing bacteria, including the formation of biofilm and the regulating effect on conjugation transfer. In addition, the possible molecular mechanisms for AHLs that promote conjugative transfer were attributable to enhancing the mRNA expression, which involved altered expressions of conjugation-related genes. We also found that QSIs could inhibit conjugative transfer by downregulating the conjugation-relevant genes. We believe that this is the first insightful exploration of the mechanism by which AHLs will facilitate and QSIs will inhibit the conjugative transfer of ARGs. These results provide creative insight into ARG pollution control that involves blocking QS during BAC treatment in drinking water systems." @default.
- W2972068110 created "2019-09-12" @default.
- W2972068110 creator A5002833257 @default.
- W2972068110 creator A5004614278 @default.
- W2972068110 creator A5023363049 @default.
- W2972068110 creator A5032226245 @default.
- W2972068110 creator A5055459701 @default.
- W2972068110 creator A5064530138 @default.
- W2972068110 creator A5067077837 @default.
- W2972068110 date "2020-01-01" @default.
- W2972068110 modified "2023-10-11" @default.
- W2972068110 title "Effect and mechanism of quorum sensing on horizontal transfer of multidrug plasmid RP4 in BAC biofilm" @default.
- W2972068110 cites W1895584462 @default.
- W2972068110 cites W1943112463 @default.
- W2972068110 cites W1958874623 @default.
- W2972068110 cites W1968834637 @default.
- W2972068110 cites W1973082589 @default.
- W2972068110 cites W1974725064 @default.
- W2972068110 cites W1980430475 @default.
- W2972068110 cites W1989098053 @default.
- W2972068110 cites W1994701620 @default.
- W2972068110 cites W1995441479 @default.
- W2972068110 cites W2002909586 @default.
- W2972068110 cites W2019515421 @default.
- W2972068110 cites W2027375167 @default.
- W2972068110 cites W2083317291 @default.
- W2972068110 cites W2087735873 @default.
- W2972068110 cites W2115590956 @default.
- W2972068110 cites W2117728545 @default.
- W2972068110 cites W2121397083 @default.
- W2972068110 cites W2124115339 @default.
- W2972068110 cites W2125603952 @default.
- W2972068110 cites W2125698022 @default.
- W2972068110 cites W2144440398 @default.
- W2972068110 cites W2170377310 @default.
- W2972068110 cites W2201784610 @default.
- W2972068110 cites W2236115745 @default.
- W2972068110 cites W2264512606 @default.
- W2972068110 cites W2334090163 @default.
- W2972068110 cites W2409422467 @default.
- W2972068110 cites W2559914803 @default.
- W2972068110 cites W2620030360 @default.
- W2972068110 cites W269102906 @default.
- W2972068110 cites W2752922960 @default.
- W2972068110 doi "https://doi.org/10.1016/j.scitotenv.2019.134236" @default.
- W2972068110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31493577" @default.
- W2972068110 hasPublicationYear "2020" @default.
- W2972068110 type Work @default.
- W2972068110 sameAs 2972068110 @default.
- W2972068110 citedByCount "41" @default.
- W2972068110 countsByYear W29720681102020 @default.
- W2972068110 countsByYear W29720681102021 @default.
- W2972068110 countsByYear W29720681102022 @default.
- W2972068110 countsByYear W29720681102023 @default.
- W2972068110 crossrefType "journal-article" @default.
- W2972068110 hasAuthorship W2972068110A5002833257 @default.
- W2972068110 hasAuthorship W2972068110A5004614278 @default.
- W2972068110 hasAuthorship W2972068110A5023363049 @default.
- W2972068110 hasAuthorship W2972068110A5032226245 @default.
- W2972068110 hasAuthorship W2972068110A5055459701 @default.
- W2972068110 hasAuthorship W2972068110A5064530138 @default.
- W2972068110 hasAuthorship W2972068110A5067077837 @default.
- W2972068110 hasConcept C104317684 @default.
- W2972068110 hasConcept C111472728 @default.
- W2972068110 hasConcept C118687296 @default.
- W2972068110 hasConcept C138885662 @default.
- W2972068110 hasConcept C141231307 @default.
- W2972068110 hasConcept C185592680 @default.
- W2972068110 hasConcept C22744801 @default.
- W2972068110 hasConcept C2908737351 @default.
- W2972068110 hasConcept C523546767 @default.
- W2972068110 hasConcept C54355233 @default.
- W2972068110 hasConcept C55493867 @default.
- W2972068110 hasConcept C58123911 @default.
- W2972068110 hasConcept C86803240 @default.
- W2972068110 hasConcept C89423630 @default.
- W2972068110 hasConcept C89611455 @default.
- W2972068110 hasConcept C92938381 @default.
- W2972068110 hasConceptScore W2972068110C104317684 @default.
- W2972068110 hasConceptScore W2972068110C111472728 @default.
- W2972068110 hasConceptScore W2972068110C118687296 @default.
- W2972068110 hasConceptScore W2972068110C138885662 @default.
- W2972068110 hasConceptScore W2972068110C141231307 @default.
- W2972068110 hasConceptScore W2972068110C185592680 @default.
- W2972068110 hasConceptScore W2972068110C22744801 @default.
- W2972068110 hasConceptScore W2972068110C2908737351 @default.
- W2972068110 hasConceptScore W2972068110C523546767 @default.
- W2972068110 hasConceptScore W2972068110C54355233 @default.
- W2972068110 hasConceptScore W2972068110C55493867 @default.
- W2972068110 hasConceptScore W2972068110C58123911 @default.
- W2972068110 hasConceptScore W2972068110C86803240 @default.
- W2972068110 hasConceptScore W2972068110C89423630 @default.
- W2972068110 hasConceptScore W2972068110C89611455 @default.
- W2972068110 hasConceptScore W2972068110C92938381 @default.
- W2972068110 hasFunder F4320321001 @default.
- W2972068110 hasLocation W29720681101 @default.
- W2972068110 hasLocation W29720681102 @default.
- W2972068110 hasOpenAccess W2972068110 @default.