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• W2972074620 endingPage "102282" @default.
• W2972074620 startingPage "102282" @default.
• W2972074620 abstract "To determine the influence of adjuvant radiotherapy on survival in surgically-managed early stage intermediate-grade mucoepidermoid and acinic cell carcinoma of the parotid. The National Cancer Database was reviewed between 2004 and 2015 to identify patients with intermediate-grade, early T-stage, node-negative parotid carcinoma who underwent parotidectomy ± radiotherapy. There were 744 patients identified of which 81% had mucoepidermoid carcinoma and 19% had acinic cell carcinoma. Positive surgical margins were identified in 21% and adjuvant radiotherapy was administered in 38% of cases. Of the 159 patients with positive margins, 113 (71%) received adjuvant radiotherapy. Of the 585 patients with negative margins, 173 (30%) underwent adjuvant radiotherapy. In multivariable analysis, age (over 52 years: HR 5.19, 95%CI 2.33–11.57), insurance status (private insurance: HR 0.24 95%CI 0.13–0.43), and extent of parotidectomy (total parotidectomy: HR 2.02 95%CI 1.23–3.31) were significantly associated with overall survival, while adjuvant radiotherapy was not a significant predictive factor (HR 0.81, 95%CI 0.49–1.36). In patients with positive margin resections, however, adjuvant radiation was an independent predictor of improved survival when adjusted for age, insurance status, and extent of parotidectomy (HR 0.34, 95%CI 0.13–0.88). Conversely, in patients with negative margin resections, adjuvant radiation did not influence survival outcomes when adjusted for these covariates (HR 1.02, 95%CI 0.53–1.93). In patients with early stage intermediate-grade parotid carcinoma, adjuvant radiotherapy significantly and independently improves survival in those with post-operative positive margins. Adjuvant therapy, however, does not appear to improve survival outcomes in those with negative margin resections." @default.
• W2972074620 created "2019-09-12" @default.
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• W2972074620 date "2019-11-01" @default.
• W2972074620 modified "2023-10-09" @default.
• W2972074620 title "Intermediate-grade carcinoma of the parotid and the impact of adjuvant radiation" @default.
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• W2972074620 doi "https://doi.org/10.1016/j.amjoto.2019.102282" @default.
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