Matches in SemOpenAlex for { <https://semopenalex.org/work/W2972080803> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2972080803 abstract "We have studied theoretically the microRNA (miRNA) intercellular transfer through voltage-gated gap junctions in terms of a biophysically grounded system of coupled differential equations. Instead of modeling a specific system, we use a general approach describing the interplay between the genetic mechanisms and the single-cell electric potentials. The dynamics of the multicellular ensemble are simulated under different conditions including spatially inhomogeneous transcription rates and local intercellular transfer of miRNAs. These processes result in spatiotemporal changes of miRNA, mRNA, and ion channel protein concentrations that eventually modify the bioelectrical states of small multicellular domains because of the ensemble average nature of the electrical potential. The simulations allow a qualitative understanding of the context-dependent nature of the effects observed when specific signaling molecules are transferred through gap junctions. The results suggest that an efficient miRNA intercellular transfer could permit the spatiotemporal control of small cellular domains by the conversion of single-cell genetic and bioelectric states into multicellular states regulated by the gap junction interconnectivity." @default.
- W2972080803 created "2019-09-12" @default.
- W2972080803 creator A5031714484 @default.
- W2972080803 creator A5042396674 @default.
- W2972080803 creator A5060787155 @default.
- W2972080803 date "2017-01-01" @default.
- W2972080803 modified "2023-09-23" @default.
- W2972080803 title "MicroRNA Intercellular Transfer and Bioelectrical Regulation of Model Multicellular Ensembles by the Gap Junction Connectivity B" @default.
- W2972080803 hasPublicationYear "2017" @default.
- W2972080803 type Work @default.
- W2972080803 sameAs 2972080803 @default.
- W2972080803 citedByCount "0" @default.
- W2972080803 crossrefType "journal-article" @default.
- W2972080803 hasAuthorship W2972080803A5031714484 @default.
- W2972080803 hasAuthorship W2972080803A5042396674 @default.
- W2972080803 hasAuthorship W2972080803A5060787155 @default.
- W2972080803 hasConcept C104317684 @default.
- W2972080803 hasConcept C114614502 @default.
- W2972080803 hasConcept C12554922 @default.
- W2972080803 hasConcept C145059251 @default.
- W2972080803 hasConcept C1491633281 @default.
- W2972080803 hasConcept C151730666 @default.
- W2972080803 hasConcept C158157758 @default.
- W2972080803 hasConcept C184720557 @default.
- W2972080803 hasConcept C185592680 @default.
- W2972080803 hasConcept C186060115 @default.
- W2972080803 hasConcept C2779343474 @default.
- W2972080803 hasConcept C33923547 @default.
- W2972080803 hasConcept C55493867 @default.
- W2972080803 hasConcept C74318829 @default.
- W2972080803 hasConcept C79879829 @default.
- W2972080803 hasConcept C86803240 @default.
- W2972080803 hasConceptScore W2972080803C104317684 @default.
- W2972080803 hasConceptScore W2972080803C114614502 @default.
- W2972080803 hasConceptScore W2972080803C12554922 @default.
- W2972080803 hasConceptScore W2972080803C145059251 @default.
- W2972080803 hasConceptScore W2972080803C1491633281 @default.
- W2972080803 hasConceptScore W2972080803C151730666 @default.
- W2972080803 hasConceptScore W2972080803C158157758 @default.
- W2972080803 hasConceptScore W2972080803C184720557 @default.
- W2972080803 hasConceptScore W2972080803C185592680 @default.
- W2972080803 hasConceptScore W2972080803C186060115 @default.
- W2972080803 hasConceptScore W2972080803C2779343474 @default.
- W2972080803 hasConceptScore W2972080803C33923547 @default.
- W2972080803 hasConceptScore W2972080803C55493867 @default.
- W2972080803 hasConceptScore W2972080803C74318829 @default.
- W2972080803 hasConceptScore W2972080803C79879829 @default.
- W2972080803 hasConceptScore W2972080803C86803240 @default.
- W2972080803 hasLocation W29720808031 @default.
- W2972080803 hasOpenAccess W2972080803 @default.
- W2972080803 hasPrimaryLocation W29720808031 @default.
- W2972080803 hasRelatedWork W105770405 @default.
- W2972080803 hasRelatedWork W14177935 @default.
- W2972080803 hasRelatedWork W1561124345 @default.
- W2972080803 hasRelatedWork W1974673184 @default.
- W2972080803 hasRelatedWork W2035536227 @default.
- W2972080803 hasRelatedWork W2041265238 @default.
- W2972080803 hasRelatedWork W2063904422 @default.
- W2972080803 hasRelatedWork W2077879893 @default.
- W2972080803 hasRelatedWork W2087376130 @default.
- W2972080803 hasRelatedWork W2167505257 @default.
- W2972080803 hasRelatedWork W2530158410 @default.
- W2972080803 hasRelatedWork W2582458430 @default.
- W2972080803 hasRelatedWork W2734874137 @default.
- W2972080803 hasRelatedWork W2893365175 @default.
- W2972080803 hasRelatedWork W2954297180 @default.
- W2972080803 hasRelatedWork W3162478879 @default.
- W2972080803 hasRelatedWork W3183690846 @default.
- W2972080803 hasRelatedWork W3195872149 @default.
- W2972080803 hasRelatedWork W3198594042 @default.
- W2972080803 hasRelatedWork W3206959665 @default.
- W2972080803 isParatext "false" @default.
- W2972080803 isRetracted "false" @default.
- W2972080803 magId "2972080803" @default.
- W2972080803 workType "article" @default.