FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2972097100> ?p ?o ?g. }

• W2972097100 abstract "Abstract Folate is an important regulator of hippocampal neurogenesis, and folic acid is needed prenatally to reduce the risk of neural tube defects. Both high levels of folic acid and low levels of folate can be harmful to health because low levels of folate have been linked to several diseases while high folic acid supplements can mask a vitamin B 12 deficiency. Depressed patients exhibit folate deficiencies, lower levels of hippocampal neurogenesis, elevated levels of homocysteine and elevated levels of the stress hormone, cortisol, which may be inter‐related. In the present study, we were interested in whether different doses of natural folate or synthetic folic acid diets can influence neurogenesis in the hippocampus, levels of plasma homocysteine and serum corticosterone in adult female rats. Adult female Sprague‐Dawley rats underwent dietary interventions for 29 days. Animals were randomly assigned to six different dietary groups: folate deficient + succinylsulphathiazole (SST), low 5‐methyltetrahydrofolate (5‐MTHF), low 5‐MTHF + (SST), high 5‐MTHF + SST, low folic acid and high folic acid. SST was added to a subset of the 5‐MTHF diets to eliminate folic acid production in the gut. Before and after dietary treatment, blood samples were collected for corticosterone and homocysteine analysis, and brain tissue was collected for neurogenesis analysis. High folic acid and low 5‐MTHF without SST increased the number of immature neurones (doublecortin‐expressing cells) within the ventral hippocampus compared to folate deficient controls. Low 5‐MTHF without SST significantly increased the number of immature neurones compared to low and high 5‐MTHF + SST, indicating that SST interfered with elevations in neurogenesis. Low folic acid and high 5‐MTHF + SST reduced plasma homocysteine levels compared to controls, although there was no significant effect of diet on serum corticosterone levels. In addition, low folic acid and high 5‐MTHF + SST reduced the number of mature new neurones in the ventral hippocampus (bromodeoxyuridine/NeuN‐positive cells) compared to folate deficient controls. Overall, folic acid dose‐dependently influenced neurogenesis with low levels decreasing but high levels increasing neurogenesis in the ventral hippocampus, suggesting that this region, which is important for regulating stress, is particularly sensitive to folic acid in diets. Furthermore, the addition of SST negated the effects of 5‐MTHF to increase neurogenesis in the ventral hippocampus." @default.
• W2972097100 created "2019-09-12" @default.
• W2972097100 creator A5002048484 @default.
• W2972097100 creator A5031602380 @default.
• W2972097100 creator A5063120236 @default.
• W2972097100 creator A5064964179 @default.
• W2972097100 creator A5077715735 @default.
• W2972097100 date "2019-10-01" @default.
• W2972097100 modified "2023-09-28" @default.
• W2972097100 title "Folic acid, but not folate, regulates different stages of neurogenesis in the ventral hippocampus of adult female rats" @default.
• W2972097100 cites W1769796040 @default.
• W2972097100 cites W1908404715 @default.
• W2972097100 cites W1945836171 @default.
• W2972097100 cites W1965505891 @default.
• W2972097100 cites W1974936050 @default.
• W2972097100 cites W1978998408 @default.
• W2972097100 cites W1979475203 @default.
• W2972097100 cites W1982541490 @default.
• W2972097100 cites W1984147168 @default.
• W2972097100 cites W1984308054 @default.
• W2972097100 cites W1987622518 @default.
• W2972097100 cites W1988694091 @default.
• W2972097100 cites W1990935979 @default.
• W2972097100 cites W1994345197 @default.
• W2972097100 cites W1998154386 @default.
• W2972097100 cites W2003844653 @default.
• W2972097100 cites W2004772633 @default.
• W2972097100 cites W2012438895 @default.
• W2972097100 cites W2042921359 @default.
• W2972097100 cites W2045668564 @default.
• W2972097100 cites W2046708720 @default.
• W2972097100 cites W2047337812 @default.
• W2972097100 cites W2048809344 @default.
• W2972097100 cites W2050938473 @default.
• W2972097100 cites W2051005796 @default.
• W2972097100 cites W2052211882 @default.
• W2972097100 cites W2052422381 @default.
• W2972097100 cites W2052654928 @default.
• W2972097100 cites W2053472601 @default.
• W2972097100 cites W2057129148 @default.
• W2972097100 cites W2058109356 @default.
• W2972097100 cites W2060918456 @default.
• W2972097100 cites W2063676248 @default.
• W2972097100 cites W2068607973 @default.
• W2972097100 cites W2068698561 @default.
• W2972097100 cites W2068741367 @default.
• W2972097100 cites W2076432328 @default.
• W2972097100 cites W2078957832 @default.
• W2972097100 cites W2079156156 @default.
• W2972097100 cites W2080715135 @default.
• W2972097100 cites W2084702387 @default.
• W2972097100 cites W2088068432 @default.
• W2972097100 cites W2089394861 @default.
• W2972097100 cites W2103085651 @default.
• W2972097100 cites W2111405228 @default.
• W2972097100 cites W2111574450 @default.
• W2972097100 cites W2112977759 @default.
• W2972097100 cites W2122398832 @default.
• W2972097100 cites W2123423715 @default.
• W2972097100 cites W2123593284 @default.
• W2972097100 cites W2126230337 @default.
• W2972097100 cites W2127935571 @default.
• W2972097100 cites W2132324173 @default.
• W2972097100 cites W2136863044 @default.
• W2972097100 cites W2139481908 @default.
• W2972097100 cites W2140129376 @default.
• W2972097100 cites W2147289196 @default.
• W2972097100 cites W2148095569 @default.
• W2972097100 cites W2148239264 @default.
• W2972097100 cites W2152482512 @default.
• W2972097100 cites W2157619189 @default.
• W2972097100 cites W2157974482 @default.
• W2972097100 cites W2159579377 @default.
• W2972097100 cites W2160376716 @default.
• W2972097100 cites W2160521610 @default.
• W2972097100 cites W2163837911 @default.
• W2972097100 cites W2166175587 @default.
• W2972097100 cites W2259276487 @default.
• W2972097100 cites W2285198650 @default.
• W2972097100 cites W2325341530 @default.
• W2972097100 cites W2399712491 @default.
• W2972097100 cites W2621388726 @default.
• W2972097100 cites W2767112609 @default.
• W2972097100 cites W4231256686 @default.
• W2972097100 cites W4241790271 @default.
• W2972097100 cites W4293877800 @default.
• W2972097100 cites W4322703313 @default.
• W2972097100 cites W4376595753 @default.
• W2972097100 doi "https://doi.org/10.1111/jne.12787" @default.
• W2972097100 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31478270" @default.
• W2972097100 hasPublicationYear "2019" @default.
• W2972097100 type Work @default.
• W2972097100 sameAs 2972097100 @default.
• W2972097100 citedByCount "5" @default.
• W2972097100 countsByYear W29720971002020 @default.
• W2972097100 countsByYear W29720971002021 @default.
• W2972097100 countsByYear W29720971002022 @default.
• W2972097100 crossrefType "journal-article" @default.
• W2972097100 hasAuthorship W2972097100A5002048484 @default.
• W2972097100 hasAuthorship W2972097100A5031602380 @default.

• next