Matches in SemOpenAlex for { <https://semopenalex.org/work/W2972145382> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2972145382 abstract "Ureteral obstruction causes injury of the renal tissues and can irreversibly progress to renal fibrosis, with atrophy and apoptosis of tubular cells. The goal of the current study was to examine the effects of rhein on the apoptosis o renal tubular cells as well as renal fibrosis using a rodent model of unilateral ureteral obstruction (UUO). UUO was induced through ureteral ligation, then animals received treatments with rhein or vehicle. The control rats only received sham operation. The renal tissue was harvested 1 week after surgery for assessment of kidney fibrosis. The expressions of collagen I and α-smooth muscle actin (α-SMA), as well as the severity of renal tubular apoptosis and fibrosis were time-dependently increased following UUO. Treatments with rhein partially inhibited such responses. Renal interstitial fibrosis was associated with STAT3 (signal transducer and activator of transcription 3) phosphorylation as well as altered expressions of Bax and Bcl2, both apoptosis-related proteins. Treatment with rhein also partly blocked these responses. These findings demonstrated that rhein mitigated apoptosis of renal tubular cell as well as renal fibrosis in a UUO rodent model. This curative effect is likely mediated via suppression of STAT3 phosphorylation." @default.
- W2972145382 created "2019-09-12" @default.
- W2972145382 creator A5002173873 @default.
- W2972145382 creator A5042998673 @default.
- W2972145382 creator A5047189000 @default.
- W2972145382 creator A5070994118 @default.
- W2972145382 creator A5086270462 @default.
- W2972145382 date "2019-09-06" @default.
- W2972145382 modified "2023-10-16" @default.
- W2972145382 title "Rhein alleviates renal interstitial fibrosis by inhibiting tubular cell apoptosis in rats" @default.
- W2972145382 cites W1974892467 @default.
- W2972145382 cites W1980325398 @default.
- W2972145382 cites W1987342012 @default.
- W2972145382 cites W2008980892 @default.
- W2972145382 cites W2011965024 @default.
- W2972145382 cites W2014763555 @default.
- W2972145382 cites W2021644664 @default.
- W2972145382 cites W2032667836 @default.
- W2972145382 cites W2049533449 @default.
- W2972145382 cites W2051576146 @default.
- W2972145382 cites W2056961869 @default.
- W2972145382 cites W2060545985 @default.
- W2972145382 cites W2067027564 @default.
- W2972145382 cites W2073294340 @default.
- W2972145382 cites W2086064946 @default.
- W2972145382 cites W2090943450 @default.
- W2972145382 cites W2110536229 @default.
- W2972145382 cites W2138897982 @default.
- W2972145382 cites W2143001791 @default.
- W2972145382 cites W2148184356 @default.
- W2972145382 cites W2156200233 @default.
- W2972145382 cites W2171992557 @default.
- W2972145382 cites W2186577008 @default.
- W2972145382 cites W2527768049 @default.
- W2972145382 cites W2591751219 @default.
- W2972145382 cites W2788561500 @default.
- W2972145382 doi "https://doi.org/10.1186/s40659-019-0257-0" @default.
- W2972145382 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6728983" @default.
- W2972145382 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31492196" @default.
- W2972145382 hasPublicationYear "2019" @default.
- W2972145382 type Work @default.
- W2972145382 sameAs 2972145382 @default.
- W2972145382 citedByCount "28" @default.
- W2972145382 countsByYear W29721453822020 @default.
- W2972145382 countsByYear W29721453822021 @default.
- W2972145382 countsByYear W29721453822022 @default.
- W2972145382 countsByYear W29721453822023 @default.
- W2972145382 crossrefType "journal-article" @default.
- W2972145382 hasAuthorship W2972145382A5002173873 @default.
- W2972145382 hasAuthorship W2972145382A5042998673 @default.
- W2972145382 hasAuthorship W2972145382A5047189000 @default.
- W2972145382 hasAuthorship W2972145382A5070994118 @default.
- W2972145382 hasAuthorship W2972145382A5086270462 @default.
- W2972145382 hasBestOaLocation W29721453821 @default.
- W2972145382 hasConcept C126322002 @default.
- W2972145382 hasConcept C134018914 @default.
- W2972145382 hasConcept C142724271 @default.
- W2972145382 hasConcept C190283241 @default.
- W2972145382 hasConcept C2778923194 @default.
- W2972145382 hasConcept C2780091579 @default.
- W2972145382 hasConcept C2780559512 @default.
- W2972145382 hasConcept C502942594 @default.
- W2972145382 hasConcept C55493867 @default.
- W2972145382 hasConcept C71924100 @default.
- W2972145382 hasConcept C86803240 @default.
- W2972145382 hasConceptScore W2972145382C126322002 @default.
- W2972145382 hasConceptScore W2972145382C134018914 @default.
- W2972145382 hasConceptScore W2972145382C142724271 @default.
- W2972145382 hasConceptScore W2972145382C190283241 @default.
- W2972145382 hasConceptScore W2972145382C2778923194 @default.
- W2972145382 hasConceptScore W2972145382C2780091579 @default.
- W2972145382 hasConceptScore W2972145382C2780559512 @default.
- W2972145382 hasConceptScore W2972145382C502942594 @default.
- W2972145382 hasConceptScore W2972145382C55493867 @default.
- W2972145382 hasConceptScore W2972145382C71924100 @default.
- W2972145382 hasConceptScore W2972145382C86803240 @default.
- W2972145382 hasIssue "1" @default.
- W2972145382 hasLocation W29721453821 @default.
- W2972145382 hasLocation W29721453822 @default.
- W2972145382 hasLocation W29721453823 @default.
- W2972145382 hasLocation W29721453824 @default.
- W2972145382 hasLocation W29721453825 @default.
- W2972145382 hasOpenAccess W2972145382 @default.
- W2972145382 hasPrimaryLocation W29721453821 @default.
- W2972145382 hasRelatedWork W2042033030 @default.
- W2972145382 hasRelatedWork W2048039626 @default.
- W2972145382 hasRelatedWork W2070511355 @default.
- W2972145382 hasRelatedWork W2082456910 @default.
- W2972145382 hasRelatedWork W2098742882 @default.
- W2972145382 hasRelatedWork W2127085070 @default.
- W2972145382 hasRelatedWork W2319873196 @default.
- W2972145382 hasRelatedWork W2400445066 @default.
- W2972145382 hasRelatedWork W2917855592 @default.
- W2972145382 hasRelatedWork W2042893290 @default.
- W2972145382 hasVolume "52" @default.
- W2972145382 isParatext "false" @default.
- W2972145382 isRetracted "false" @default.
- W2972145382 magId "2972145382" @default.
- W2972145382 workType "article" @default.