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• W2972150427 abstract "Irisin is a newly identified cytokine that has gained increasing attention because of its potential therapeutic applications in metabolic diseases and human cancers. Recently, accumulating evidence indicates that irisin plays an important role in the development and metastasis of various tumors. The aim of this study was to evaluate the effects and underlying mechanisms of irisin on malignant growth of pancreatic cancer cells.The anti-proliferative effect of irisin was examined using the CCK-8 assay. Irisin-induced apoptosis was determined by the annexin V-FITC/PI staining assay. The effects of irisin on cell migration and invasion were assessed using the scratch-induced wound healing assay and transwell invasion assay, respectively. The expression and phosphorylation of signaling proteins were detected by Western blot analysis.Our results showed that irisin inhibited cell proliferation and induced apoptosis of pancreatic cancer cells in a dose-dependent manner. In addition, irisin decreased the migration and invasion of pancreatic cancer cells. Finally, Western blot analysis revealed that irisin downregulated the PI3K/AKT signaling pathway.Our findings suggest that irisin is a novel therapeutic agent for pancreatic cancer." @default.
• W2972150427 created "2019-09-12" @default.
• W2972150427 creator A5001461306 @default.
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• W2972150427 date "2019-09-01" @default.
• W2972150427 modified "2023-10-12" @default.
• W2972150427 title "<p>Irisin functions to inhibit malignant growth of human pancreatic cancer cells via downregulation of the PI3K/AKT signaling pathway</p>" @default.
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• W2972150427 doi "https://doi.org/10.2147/ott.s214260" @default.
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• W2972150427 hasPublicationYear "2019" @default.
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