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- W2972163969 abstract "In most patients with acute myeloid leukemia (AML), leukemic cells become undetectable after chemotherapy. Nevertheless, leukemia may subsequently relapse due to minimal residual disease (MRD). Flow cytometric monitoring of MRD is prognostically informative. However immunophenotypic shifts at relapse is possible and may limit flow cytometric MRD-testing. Our objective was to evaluate the antigen changes in our AML patients. Patients diagnosed between September 2002 and November 2016 were analyzed retrospectively. Bone marrow samples were collected at diagnosis and relapse from 40 patients with de novo (n=34) or secondary (n=6) AML, aged 19 to 77 years. Bone marrow samples were collected into tubes containing K3EDTA. Phycoerhtyrine (PE) and fluorescein isothiocyanate (FITC) (eBioscience and BD Bioscience, San Jose, California) surface antigens were used according to the routine panel used in our laboratory. Analyses were done according to CD45 SSC gating strategy by Becton Dickinson FACSCalibur device. Overall, 34 of 40 (85%) cases showed changes (gain and/or loss of antigen) of at least one marker (n=10). Antigen changes were observed in 2 (n=7), 3 (n=6), 4 (n=6), 5 (n=4) or 6 (n=1) antigens in other patients. Antigen changes were found in 16 of 18 antigens (88.9%) totally. CD20 and CD45 were the only antigens with no change. Patients with AML demonstrate a high frequency of immunophenotypic shift at relapse. Antigen changes at relapse should be kept in mind in the minimal residual disease era." @default.
- W2972163969 created "2019-09-12" @default.
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- W2972163969 date "2019-09-04" @default.
- W2972163969 modified "2023-09-27" @default.
- W2972163969 title "Akut Miyeloid Lösemili Hastaların Tanı ve Relaps Dönemindeki Akım Sitometri Sonuçlarının Karşılaştırılması" @default.
- W2972163969 doi "https://doi.org/10.20515/otd.556591" @default.
- W2972163969 hasPublicationYear "2019" @default.
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