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- W2972180417 abstract "The effects of six metal oxide nanoparticles (MO-NPs) on the activity and biosynthesis of an enzyme ( β -galactosidase) were examined using a mutant strain of E. coli . Different sensitivities were observed according to the type of NP and metabolic process. The toxic effects on enzyme activity were significantly greater than on biosynthesis (p < 0.011), except in the presence of NiO. In both cases, ZnO NP caused the greatest inhibition among the tested NPs, followed by CuO. The EC 50s for ZnO were 0.19 and 3.68 mg/L for enzyme activity and biosynthesis, respectively. Similar orders of toxicity were observed as follows: ZnO > CuO > NiO > Co 3 O 4 > TiO 2 , Al 2 O 3 for enzyme activity; and ZnO > CuO > NiO ≫ Al 2 O 3 , TiO 2 , Co 3 O 4 for the biosynthetic process. More systematic research, including in-depth studies like investigation of the molecular mechanisms, is necessary to elucidate the detailed mechanisms of inhibition involved in both metabolic processes." @default.
- W2972180417 created "2019-09-12" @default.
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- W2972180417 date "2020-03-01" @default.
- W2972180417 modified "2023-09-27" @default.
- W2972180417 title "Toxic Effects of Metal Oxide Nanoparticles Based on the Enzymatic Activity and Biosynthesis of β-Galactosidase Using a Mutant Strain of E. coli" @default.
- W2972180417 doi "https://doi.org/10.1166/jnn.2020.17156" @default.
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