FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2972184156> ?p ?o ?g. }

• W2972184156 abstract "The identification of functional modules in gene interaction networks is a key step in understanding biological processes. Network interpretation is essential for unveiling biological mechanisms, candidate biomarkers, or potential targets for drug discovery/repositioning. Plenty of biological module identification algorithms are available, although none is explicitly designed to perform the task on single-cell RNA sequencing (scRNA-seq) data. Here, we introduce MTGO-SC, an adaptation for scRNA-seq of our biological network module detection algorithm MTGO. MTGO-SC isolates gene functional modules by leveraging on both the network topological structure and the annotations characterizing the nodes (genes). These annotations are provided by an external source, such as databases and literature repositories (e.g., the Gene Ontology, Reactome). Thanks to the depth of single-cell data, it is possible to define one network for each cell cluster (typically, cell type or state) composing each sample, as opposed to traditional bulk RNA-seq, where the emerging gene network is averaged over the whole sample. MTGO-SC provides two complexity levels for interpretation: the gene-gene interaction and the intermodule interaction networks. MTGO-SC is versatile in letting the users define the rules to extract the gene network and integrated with the Seurat scRNA-seq analysis pipeline. MTGO-SC is available at https://github.com/ne1s0n/MTGOsc." @default.
• W2972184156 created "2019-09-12" @default.
• W2972184156 creator A5004394877 @default.
• W2972184156 creator A5026545305 @default.
• W2972184156 creator A5036834669 @default.
• W2972184156 creator A5046161612 @default.
• W2972184156 creator A5047164157 @default.
• W2972184156 creator A5050932220 @default.
• W2972184156 date "2019-10-09" @default.
• W2972184156 modified "2023-09-27" @default.
• W2972184156 title "MTGO-SC, A Tool to Explore Gene Modules in Single-Cell RNA Sequencing Data" @default.
• W2972184156 cites W1921058547 @default.
• W2972184156 cites W1964514079 @default.
• W2972184156 cites W1964756196 @default.
• W2972184156 cites W1991910899 @default.
• W2972184156 cites W1996287409 @default.
• W2972184156 cites W2005630031 @default.
• W2972184156 cites W2014077602 @default.
• W2972184156 cites W2031673728 @default.
• W2972184156 cites W2040581784 @default.
• W2972184156 cites W2057495467 @default.
• W2972184156 cites W2065818549 @default.
• W2972184156 cites W2069091317 @default.
• W2972184156 cites W2092247630 @default.
• W2972184156 cites W2095293504 @default.
• W2972184156 cites W2127048411 @default.
• W2972184156 cites W2148043260 @default.
• W2972184156 cites W2171273050 @default.
• W2972184156 cites W2172557341 @default.
• W2972184156 cites W2467724195 @default.
• W2972184156 cites W2470397061 @default.
• W2972184156 cites W2746479894 @default.
• W2972184156 cites W2788348358 @default.
• W2972184156 cites W2790748465 @default.
• W2972184156 cites W2794480084 @default.
• W2972184156 cites W2801069509 @default.
• W2972184156 cites W2903803003 @default.
• W2972184156 cites W2916865346 @default.
• W2972184156 cites W2929810236 @default.
• W2972184156 cites W2954782182 @default.
• W2972184156 cites W4243979784 @default.
• W2972184156 cites W2951455477 @default.
• W2972184156 doi "https://doi.org/10.3389/fgene.2019.00953" @default.
• W2972184156 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6794379" @default.
• W2972184156 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31649730" @default.
• W2972184156 hasPublicationYear "2019" @default.
• W2972184156 type Work @default.
• W2972184156 sameAs 2972184156 @default.
• W2972184156 citedByCount "3" @default.
• W2972184156 countsByYear W29721841562020 @default.
• W2972184156 countsByYear W29721841562021 @default.
• W2972184156 crossrefType "journal-article" @default.
• W2972184156 hasAuthorship W2972184156A5004394877 @default.
• W2972184156 hasAuthorship W2972184156A5026545305 @default.
• W2972184156 hasAuthorship W2972184156A5036834669 @default.
• W2972184156 hasAuthorship W2972184156A5046161612 @default.
• W2972184156 hasAuthorship W2972184156A5047164157 @default.
• W2972184156 hasAuthorship W2972184156A5050932220 @default.
• W2972184156 hasBestOaLocation W29721841561 @default.
• W2972184156 hasConcept C104317684 @default.
• W2972184156 hasConcept C107397762 @default.
• W2972184156 hasConcept C116834253 @default.
• W2972184156 hasConcept C124101348 @default.
• W2972184156 hasConcept C150194340 @default.
• W2972184156 hasConcept C162317418 @default.
• W2972184156 hasConcept C199360897 @default.
• W2972184156 hasConcept C201797286 @default.
• W2972184156 hasConcept C26517878 @default.
• W2972184156 hasConcept C28225019 @default.
• W2972184156 hasConcept C2987395477 @default.
• W2972184156 hasConcept C38652104 @default.
• W2972184156 hasConcept C41008148 @default.
• W2972184156 hasConcept C43521106 @default.
• W2972184156 hasConcept C54355233 @default.
• W2972184156 hasConcept C55105296 @default.
• W2972184156 hasConcept C59822182 @default.
• W2972184156 hasConcept C60644358 @default.
• W2972184156 hasConcept C67339327 @default.
• W2972184156 hasConcept C70721500 @default.
• W2972184156 hasConcept C86803240 @default.
• W2972184156 hasConceptScore W2972184156C104317684 @default.
• W2972184156 hasConceptScore W2972184156C107397762 @default.
• W2972184156 hasConceptScore W2972184156C116834253 @default.
• W2972184156 hasConceptScore W2972184156C124101348 @default.
• W2972184156 hasConceptScore W2972184156C150194340 @default.
• W2972184156 hasConceptScore W2972184156C162317418 @default.
• W2972184156 hasConceptScore W2972184156C199360897 @default.
• W2972184156 hasConceptScore W2972184156C201797286 @default.
• W2972184156 hasConceptScore W2972184156C26517878 @default.
• W2972184156 hasConceptScore W2972184156C28225019 @default.
• W2972184156 hasConceptScore W2972184156C2987395477 @default.
• W2972184156 hasConceptScore W2972184156C38652104 @default.
• W2972184156 hasConceptScore W2972184156C41008148 @default.
• W2972184156 hasConceptScore W2972184156C43521106 @default.
• W2972184156 hasConceptScore W2972184156C54355233 @default.
• W2972184156 hasConceptScore W2972184156C55105296 @default.
• W2972184156 hasConceptScore W2972184156C59822182 @default.
• W2972184156 hasConceptScore W2972184156C60644358 @default.
• W2972184156 hasConceptScore W2972184156C67339327 @default.
• W2972184156 hasConceptScore W2972184156C70721500 @default.

• next