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- W2972198710 abstract "Lymphatic vessels play important roles in immune defense, inflammatory diseases, and cancer. In the steady state, lymphatic vessels are responsible for collecting fluid and cells from the dermis to maintain fluid homeostasis. The structures of lymphatic vessels have been reported by enzyme histochemistry, immunohistochemistry, scanning electron microscopy (SEM), and transmission electron microscopy (TEM). However, the detailed morphology of lymphatic vessels is still unknown. Here, we investigated the ultrastructure of human cutaneous lymphatic vessels by immuno-TEM and focused ion beam (FIB)-SEM that generates high resolution and back scattered images resembling those of a transmission electron micrograph. First, we investigated tight junctions of lymphatic vessels by correlative light and electron microscopy. The confocal laser micrograph and immuno-TEM image indicated that claudin-5 was expressed at the tight junctions of lymphatic endothelial cells. Next, we analyzed the three-dimensional ultrastructure of lymphatic vessels by FIB-SEM. The FIB-SEM image revealed the detailed ultrastructures of lymphatic vessels and valves. Lymphatic endothelial cells were connected to each other at the edge of cell membranes. We also observed that cell debris was collected at the lumen of lymphatic vessels through the spaces between tight junctions. Furthermore, it appeared that protrusions, which were generated from lymphatic endothelial cells, elongated to the cell debris in the dermis. Taken together, lymphatic endothelial cells may be able to actively search for and collect cell debris." @default.
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- W2972198710 date "2019-09-01" @default.
- W2972198710 modified "2023-09-28" @default.
- W2972198710 title "638 Three-dimensional ultrastructural analysis of lymphatic vessels in human dermis" @default.
- W2972198710 doi "https://doi.org/10.1016/j.jid.2019.07.643" @default.
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