FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2972236586> ?p ?o ?g. }

• W2972236586 endingPage "114136" @default.
• W2972236586 startingPage "114136" @default.
• W2972236586 abstract "Abstract Eight platinum(II) complexes of the general formula cis-[PtCl2(L)2] containing 7-azaindole (L = 7AIH) and its halogeno-derivatives: L = 3-chloro-7-azaindole (3Cl7AIH); 3-bromo-7-azaindole (3Br7AIH); 4-chloro-7-azaindole (4Cl7AIH); 4-bromo-7-azaindole (4Br7AIH); 5-bromo-7-azaindole (5Br7AIH); 3-bromo-4-chloro-7-azaindole (3Br4Cl7AIH) and 5-bromo-3-chloro-7-azaindole (5Br3Cl7AIH) were prepared. Two complexes, cis-[PtCl2(3Br4Cl7AIH)2] (2) and cis-[PtCl2(4Br7AIH)2]·DMF, are reported for the first time. Crystal structure of the latter compound has been determined with X-ray diffraction analysis (space group P43, with a = 14.775(2), c = 41.640(8) A, V = 9090(3) A3 and Z = 16). For all of these complexes, formation of the cis isomers in the solid state was confirmed by experimental vibrational (IR and Raman) spectroscopy combined with DFT calculations. A complete assignment of the IR and Raman spectra was made on the basis of the calculated potential energy distribution (PED). Stability of complex (2) in DMSO solution was investigated by FT-IR (ATR) spectroscopy. The in vitro antiproliferative activity of cis-[PtCl2(3Br4Cl7AIH)2], cis-[PtCl2(3Cl7AIH)2] and cis-[PtCl2(3Br7AIH)2] was evaluated on selected human cancer cell lines and towards normal mouse fibroblast cell line (BALB/3T3). All complexes are more toxic than cisplatin against Es-2 (ovarian cancer), LNCaP (prostate adenocarcinoma) and MCF7 (breast cancer). Moreover, complex (2) is significantly more active than the other complexes on A549 (lung carcinoma, IC50 = 3.9 μM). However, the three investigated Pt(II) complexes with 7-azaindoles have revealed higher cytotoxicity against a normal cell line (BALB/3T3), in comparison to cisplatin." @default.
• W2972236586 created "2019-09-12" @default.
• W2972236586 creator A5012887891 @default.
• W2972236586 creator A5025312248 @default.
• W2972236586 creator A5033386472 @default.
• W2972236586 creator A5053931786 @default.
• W2972236586 creator A5058539851 @default.
• W2972236586 creator A5063252664 @default.
• W2972236586 creator A5064563706 @default.
• W2972236586 creator A5090160131 @default.
• W2972236586 date "2019-11-01" @default.
• W2972236586 modified "2023-10-02" @default.
• W2972236586 title "A comparative study on cisplatin analogs containing 7-azaindole (7AIH) and its seven halogeno-derivatives: Vibrational spectra, DFT calculations and in vitro antiproliferative activity. Crystal and molecular structure of cis-[PtCl2(4Br7AIH)2]·DMF" @default.
• W2972236586 cites W1173357410 @default.
• W2972236586 cites W1845532486 @default.
• W2972236586 cites W1917230097 @default.
• W2972236586 cites W1966644316 @default.
• W2972236586 cites W1967036727 @default.
• W2972236586 cites W1968339413 @default.
• W2972236586 cites W1969360633 @default.
• W2972236586 cites W1971275758 @default.
• W2972236586 cites W1982294311 @default.
• W2972236586 cites W1990170643 @default.
• W2972236586 cites W1993614928 @default.
• W2972236586 cites W1997365666 @default.
• W2972236586 cites W2006830244 @default.
• W2972236586 cites W2012488984 @default.
• W2972236586 cites W2020936495 @default.
• W2972236586 cites W2021550008 @default.
• W2972236586 cites W2023271753 @default.
• W2972236586 cites W2036211008 @default.
• W2972236586 cites W2039412968 @default.
• W2972236586 cites W2039478062 @default.
• W2972236586 cites W2046384376 @default.
• W2972236586 cites W2049996223 @default.
• W2972236586 cites W2055089674 @default.
• W2972236586 cites W2068617439 @default.
• W2972236586 cites W2086957099 @default.
• W2972236586 cites W2087507121 @default.
• W2972236586 cites W2101043381 @default.
• W2972236586 cites W2102515251 @default.
• W2972236586 cites W2109689528 @default.
• W2972236586 cites W2139794951 @default.
• W2972236586 cites W2148284063 @default.
• W2972236586 cites W2153906296 @default.
• W2972236586 cites W2167390027 @default.
• W2972236586 cites W2282989227 @default.
• W2972236586 cites W2408989340 @default.
• W2972236586 cites W2518409068 @default.
• W2972236586 cites W2571440087 @default.
• W2972236586 cites W2707233952 @default.
• W2972236586 cites W2757474414 @default.
• W2972236586 cites W2774374884 @default.
• W2972236586 cites W2806698290 @default.
• W2972236586 cites W2858595186 @default.
• W2972236586 cites W2906885313 @default.
• W2972236586 cites W2918300848 @default.
• W2972236586 cites W2942184209 @default.
• W2972236586 cites W2951771764 @default.
• W2972236586 cites W2616144598 @default.
• W2972236586 doi "https://doi.org/10.1016/j.poly.2019.114136" @default.
• W2972236586 hasPublicationYear "2019" @default.
• W2972236586 type Work @default.
• W2972236586 sameAs 2972236586 @default.
• W2972236586 citedByCount "4" @default.
• W2972236586 countsByYear W29722365862020 @default.
• W2972236586 crossrefType "journal-article" @default.
• W2972236586 hasAuthorship W2972236586A5012887891 @default.
• W2972236586 hasAuthorship W2972236586A5025312248 @default.
• W2972236586 hasAuthorship W2972236586A5033386472 @default.
• W2972236586 hasAuthorship W2972236586A5053931786 @default.
• W2972236586 hasAuthorship W2972236586A5058539851 @default.
• W2972236586 hasAuthorship W2972236586A5063252664 @default.
• W2972236586 hasAuthorship W2972236586A5064563706 @default.
• W2972236586 hasAuthorship W2972236586A5090160131 @default.
• W2972236586 hasConcept C115624301 @default.
• W2972236586 hasConcept C141071460 @default.
• W2972236586 hasConcept C147597530 @default.
• W2972236586 hasConcept C178790620 @default.
• W2972236586 hasConcept C185592680 @default.
• W2972236586 hasConcept C202751555 @default.
• W2972236586 hasConcept C2776694085 @default.
• W2972236586 hasConcept C2778239845 @default.
• W2972236586 hasConcept C32909587 @default.
• W2972236586 hasConcept C55493867 @default.
• W2972236586 hasConcept C71240020 @default.
• W2972236586 hasConcept C71924100 @default.
• W2972236586 hasConcept C8010536 @default.
• W2972236586 hasConceptScore W2972236586C115624301 @default.
• W2972236586 hasConceptScore W2972236586C141071460 @default.
• W2972236586 hasConceptScore W2972236586C147597530 @default.
• W2972236586 hasConceptScore W2972236586C178790620 @default.
• W2972236586 hasConceptScore W2972236586C185592680 @default.
• W2972236586 hasConceptScore W2972236586C202751555 @default.
• W2972236586 hasConceptScore W2972236586C2776694085 @default.
• W2972236586 hasConceptScore W2972236586C2778239845 @default.
• W2972236586 hasConceptScore W2972236586C32909587 @default.
• W2972236586 hasConceptScore W2972236586C55493867 @default.

• next