FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2972257369> ?p ?o ?g. }

• W2972257369 endingPage "734481" @default.
• W2972257369 startingPage "734481" @default.
• W2972257369 abstract "Abstract Stress has a considerable impact on the welfare and productivity of fish, and stress caused by transport and handling can result in mortality rates of up to 73%. Cortisol is the major corticosteroid produced by the hypothalamic-pituitary-interrenal axis (HPI) in several stressful conditions, and high plasma cortisol levels impair immune and inflammatory responses. However, the involvement of purinergic signaling, a system that might contribute to the fine tuning of inflammatory and immune responses caused by the stress response, remains unknown in fish subjected to handling stress. Thus, the aim of this study was to evaluate the involvement of purinergic signaling with the immune response of the Amazon fish bodo (Pterygoplichthys pardalis) to acute handling stress. Plasma cortisol levels were higher 240 min post-stress in fish subjected to handling than in the control group. Plasma triphosphate diphosphohydrolase (NTPDase) activity, using adenosine triphosphate (ATP) as a substrate, was upregulated 30 min post-stress in fish subjected to handling, whereas splenic NTPDase activity was downregulated 240 min post-stress compared to the control group. No significant difference was observed between the groups regarding plasma and spleen NTPDase (using adenosine diphosphate as substrate) and 5′-nucleotidase and adenosine deaminase (ADA) activities. The levels of nitric oxide metabolites (NOx) and ATP in the spleen were higher 240 min post-stress in fish subjected to handling, although no significant difference was observed in the plasma levels. Based on these results, purinergic signaling via regulation of extracellular ATP catabolism could be involved in the immunophysiological responses of bodo subjected to acute handling stress, exerting two different profiles. In plasma, this signaling contributes to a reduction in the systemic inflammatory response, however, inhibition of ATP hydrolysis in the spleen displayed a pro-inflammatory profile due to the excessive ATP levels in the extracellular milieu, which induced the release of pro-inflammatory mediators. Thus, NTPDase activity could be a pathway associated with the immunophysiological responses of bodo to acute handling stress." @default.
• W2972257369 created "2019-09-12" @default.
• W2972257369 creator A5011185858 @default.
• W2972257369 creator A5022367997 @default.
• W2972257369 creator A5032679344 @default.
• W2972257369 creator A5033476328 @default.
• W2972257369 date "2020-01-01" @default.
• W2972257369 modified "2023-09-23" @default.
• W2972257369 title "Involvement of purinergic signaling in the Amazon fish Pterygoplichthys pardalis subjected to handling stress: Relationship with immune response" @default.
• W2972257369 cites W1543561630 @default.
• W2972257369 cites W1593579053 @default.
• W2972257369 cites W1978378281 @default.
• W2972257369 cites W1997180556 @default.
• W2972257369 cites W1999917511 @default.
• W2972257369 cites W2006328376 @default.
• W2972257369 cites W2008320321 @default.
• W2972257369 cites W2020615506 @default.
• W2972257369 cites W2039495394 @default.
• W2972257369 cites W2053185870 @default.
• W2972257369 cites W2068251735 @default.
• W2972257369 cites W2070591539 @default.
• W2972257369 cites W2078877443 @default.
• W2972257369 cites W2079145025 @default.
• W2972257369 cites W2081767139 @default.
• W2972257369 cites W2093852864 @default.
• W2972257369 cites W2121212243 @default.
• W2972257369 cites W2126214604 @default.
• W2972257369 cites W2131577298 @default.
• W2972257369 cites W2138406713 @default.
• W2972257369 cites W2225272104 @default.
• W2972257369 cites W2397873637 @default.
• W2972257369 cites W2402623134 @default.
• W2972257369 cites W241515049 @default.
• W2972257369 cites W2495351417 @default.
• W2972257369 cites W2554062809 @default.
• W2972257369 cites W2623584530 @default.
• W2972257369 cites W2735660234 @default.
• W2972257369 cites W2737911336 @default.
• W2972257369 cites W2757108515 @default.
• W2972257369 cites W2791365824 @default.
• W2972257369 cites W2793479725 @default.
• W2972257369 cites W2884278538 @default.
• W2972257369 cites W2902632255 @default.
• W2972257369 cites W2910498803 @default.
• W2972257369 cites W2911249705 @default.
• W2972257369 cites W2911533387 @default.
• W2972257369 cites W778114268 @default.
• W2972257369 doi "https://doi.org/10.1016/j.aquaculture.2019.734481" @default.
• W2972257369 hasPublicationYear "2020" @default.
• W2972257369 type Work @default.
• W2972257369 sameAs 2972257369 @default.
• W2972257369 citedByCount "8" @default.
• W2972257369 countsByYear W29722573692020 @default.
• W2972257369 countsByYear W29722573692021 @default.
• W2972257369 countsByYear W29722573692022 @default.
• W2972257369 countsByYear W29722573692023 @default.
• W2972257369 crossrefType "journal-article" @default.
• W2972257369 hasAuthorship W2972257369A5011185858 @default.
• W2972257369 hasAuthorship W2972257369A5022367997 @default.
• W2972257369 hasAuthorship W2972257369A5032679344 @default.
• W2972257369 hasAuthorship W2972257369A5033476328 @default.
• W2972257369 hasConcept C104317684 @default.
• W2972257369 hasConcept C159047783 @default.
• W2972257369 hasConcept C18903297 @default.
• W2972257369 hasConcept C28406088 @default.
• W2972257369 hasConcept C2909208804 @default.
• W2972257369 hasConcept C505870484 @default.
• W2972257369 hasConcept C535291247 @default.
• W2972257369 hasConcept C54355233 @default.
• W2972257369 hasConcept C57306754 @default.
• W2972257369 hasConcept C78604142 @default.
• W2972257369 hasConcept C86803240 @default.
• W2972257369 hasConcept C8891405 @default.
• W2972257369 hasConcept C90856448 @default.
• W2972257369 hasConceptScore W2972257369C104317684 @default.
• W2972257369 hasConceptScore W2972257369C159047783 @default.
• W2972257369 hasConceptScore W2972257369C18903297 @default.
• W2972257369 hasConceptScore W2972257369C28406088 @default.
• W2972257369 hasConceptScore W2972257369C2909208804 @default.
• W2972257369 hasConceptScore W2972257369C505870484 @default.
• W2972257369 hasConceptScore W2972257369C535291247 @default.
• W2972257369 hasConceptScore W2972257369C54355233 @default.
• W2972257369 hasConceptScore W2972257369C57306754 @default.
• W2972257369 hasConceptScore W2972257369C78604142 @default.
• W2972257369 hasConceptScore W2972257369C86803240 @default.
• W2972257369 hasConceptScore W2972257369C8891405 @default.
• W2972257369 hasConceptScore W2972257369C90856448 @default.
• W2972257369 hasFunder F4320321091 @default.
• W2972257369 hasFunder F4320322025 @default.
• W2972257369 hasFunder F4320322994 @default.
• W2972257369 hasFunder F4320324382 @default.
• W2972257369 hasLocation W29722573691 @default.
• W2972257369 hasOpenAccess W2972257369 @default.
• W2972257369 hasPrimaryLocation W29722573691 @default.
• W2972257369 hasRelatedWork W1702322095 @default.
• W2972257369 hasRelatedWork W1865764402 @default.
• W2972257369 hasRelatedWork W1968224621 @default.
• W2972257369 hasRelatedWork W1975114493 @default.

• next