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• W2972257467 abstract "Objective Many hepatitis C virus (HCV)-infected patients have a suboptimal diagnosis. Particularly, the characteristics and risk of fibrosis progression of HCV antibody-positive patients without RNA testing are unknown. Methods Patients with a positive HCV antibody performed during 2005–2007 were classified based on RNA request and result until January 2017. Fibrosis was estimated with serologic scores. Results Of the 38 246 HCV tests performed, 791 (2.01%) patients tested positive. At the end of the follow-up (median 128.6 months, range 109.8–145.9), 49.43% ( n = 391) of the subjects did not have RNA testing, 13.02% ( n = 103) had undetectable RNA, and 37.55% ( n = 297) had detectable RNA. After excluding patients without data for AST to platelet ratio index calculation ( n = 334), patients without RNA testing ( n = 122) compared with RNA undetectable ( n = 92) were more frequently men (68.9 versus 46.7%), alcohol (52.6 versus 38.2%) and drug (53.0 versus 39.1%) users, lacking social support (50.4 versus 29.3%), and showed higher basal fibrosis. Patients without RNA testing had a significantly higher increase in the percentage of patients with ≥F2 ( P = 0.035) and cirrhosis ( P = 0.022). The relative risk for ≥F2 and cirrhosis in patients without RNA testing was 3.03 [95% confidence interval (CI): 1.54–5.98] and 4.31 (95% CI: 1.42–13.10), respectively. Non-RNA request was an independent predictor factor for progression to cirrhosis. Conclusion In our cohort, patients with positive HCV antibody without RNA testing were more likely to be people at risk of social exclusion with an increased risk of fibrosis progression, because non-RNA request was a predictor for cirrhosis. Therefore, we urge support measures and strategies to link to care these difficult-to-treat populations." @default.
• W2972257467 created "2019-09-12" @default.
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• W2972257467 date "2020-04-01" @default.
• W2972257467 modified "2023-10-14" @default.
• W2972257467 title "Risk of liver fibrosis progression in patients with suboptimal diagnosis of hepatitis C virus infection" @default.
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• W2972257467 doi "https://doi.org/10.1097/meg.0000000000001534" @default.
• W2972257467 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31490420" @default.
• W2972257467 hasPublicationYear "2020" @default.
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