FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2972284386> ?p ?o ?g. }

• W2972284386 endingPage "106" @default.
• W2972284386 startingPage "98" @default.
• W2972284386 abstract "Abstract Coumarins are the most important class of natural compounds found widely in various plants. Many coumarin derivatives with different biological and pharmacological activities have been synthesized. In this study, the antiapoptotic and cytotoxic effects and DNA‐binding properties of some synthetic coumarin derivatives (4b, 4d, 4f, 4 g (DBP‐g), 4 h and 4j) against K562 cell lines were investigated using different techniques. MTT assay indicated that the DBP‐g compound was more active than other derivatives, with a IC 50 value of 55 μM, and therefore this compound was chosen for further investigation. Apoptosis induction was assessed using acridine orange/ethidium bromide double‐staining and cell‐cycle analysis. In addition, in vitro DNA‐binding studies were carried out using ultraviolet–visible light absorption and fluorescence spectroscopy, as well as viscosity measurement and molecular modelling studies. In vitro results indicated that DBP‐g interacted with DNA through a groove‐binding mode with a binding constant ( K b ) of 1.17 × 10 4 M −1 . In agreement with other experimental data, molecular docking studies showed that DBP‐g is a minor groove binder. Overall, it can be concluded that DBP‐g could be used as an effective and novel chemotherapeutic agent." @default.
• W2972284386 created "2019-09-12" @default.
• W2972284386 creator A5034372075 @default.
• W2972284386 creator A5052175651 @default.
• W2972284386 creator A5058799401 @default.
• W2972284386 creator A5081118858 @default.
• W2972284386 date "2019-09-02" @default.
• W2972284386 modified "2023-10-02" @default.
• W2972284386 title "DNA‐binding activity and cytotoxic and cell‐cycle arrest properties of some new coumarin derivatives: a multispectral and computational investigation" @default.
• W2972284386 cites W135709300 @default.
• W2972284386 cites W1793373338 @default.
• W2972284386 cites W1933341309 @default.
• W2972284386 cites W1963706901 @default.
• W2972284386 cites W1975376070 @default.
• W2972284386 cites W1983192515 @default.
• W2972284386 cites W1984904372 @default.
• W2972284386 cites W1999911756 @default.
• W2972284386 cites W2014889543 @default.
• W2972284386 cites W2023779399 @default.
• W2972284386 cites W2027310997 @default.
• W2972284386 cites W2052419452 @default.
• W2972284386 cites W2066204569 @default.
• W2972284386 cites W2070763547 @default.
• W2972284386 cites W2074305443 @default.
• W2972284386 cites W2116191481 @default.
• W2972284386 cites W2138685395 @default.
• W2972284386 cites W2139224077 @default.
• W2972284386 cites W2148738581 @default.
• W2972284386 cites W2150157042 @default.
• W2972284386 cites W2158025958 @default.
• W2972284386 cites W2171530299 @default.
• W2972284386 cites W2203384105 @default.
• W2972284386 cites W2236676365 @default.
• W2972284386 cites W2280415001 @default.
• W2972284386 cites W2317839731 @default.
• W2972284386 cites W2347064253 @default.
• W2972284386 cites W2529168064 @default.
• W2972284386 cites W2595844384 @default.
• W2972284386 cites W2604219750 @default.
• W2972284386 cites W2609830611 @default.
• W2972284386 cites W2624428722 @default.
• W2972284386 cites W2624854612 @default.
• W2972284386 cites W2766539732 @default.
• W2972284386 cites W2769486622 @default.
• W2972284386 cites W2789288308 @default.
• W2972284386 doi "https://doi.org/10.1002/bio.3702" @default.
• W2972284386 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31475787" @default.
• W2972284386 hasPublicationYear "2019" @default.
• W2972284386 type Work @default.
• W2972284386 sameAs 2972284386 @default.
• W2972284386 citedByCount "7" @default.
• W2972284386 countsByYear W29722843862020 @default.
• W2972284386 countsByYear W29722843862021 @default.
• W2972284386 countsByYear W29722843862022 @default.
• W2972284386 countsByYear W29722843862023 @default.
• W2972284386 crossrefType "journal-article" @default.
• W2972284386 hasAuthorship W2972284386A5034372075 @default.
• W2972284386 hasAuthorship W2972284386A5052175651 @default.
• W2972284386 hasAuthorship W2972284386A5058799401 @default.
• W2972284386 hasAuthorship W2972284386A5081118858 @default.
• W2972284386 hasConcept C107824862 @default.
• W2972284386 hasConcept C109316439 @default.
• W2972284386 hasConcept C121332964 @default.
• W2972284386 hasConcept C178790620 @default.
• W2972284386 hasConcept C178910836 @default.
• W2972284386 hasConcept C185592680 @default.
• W2972284386 hasConcept C190283241 @default.
• W2972284386 hasConcept C202751555 @default.
• W2972284386 hasConcept C2776907736 @default.
• W2972284386 hasConcept C2779102032 @default.
• W2972284386 hasConcept C2780783641 @default.
• W2972284386 hasConcept C2781338262 @default.
• W2972284386 hasConcept C32786932 @default.
• W2972284386 hasConcept C552990157 @default.
• W2972284386 hasConcept C55493867 @default.
• W2972284386 hasConcept C62520636 @default.
• W2972284386 hasConcept C71240020 @default.
• W2972284386 hasConcept C91881484 @default.
• W2972284386 hasConceptScore W2972284386C107824862 @default.
• W2972284386 hasConceptScore W2972284386C109316439 @default.
• W2972284386 hasConceptScore W2972284386C121332964 @default.
• W2972284386 hasConceptScore W2972284386C178790620 @default.
• W2972284386 hasConceptScore W2972284386C178910836 @default.
• W2972284386 hasConceptScore W2972284386C185592680 @default.
• W2972284386 hasConceptScore W2972284386C190283241 @default.
• W2972284386 hasConceptScore W2972284386C202751555 @default.
• W2972284386 hasConceptScore W2972284386C2776907736 @default.
• W2972284386 hasConceptScore W2972284386C2779102032 @default.
• W2972284386 hasConceptScore W2972284386C2780783641 @default.
• W2972284386 hasConceptScore W2972284386C2781338262 @default.
• W2972284386 hasConceptScore W2972284386C32786932 @default.
• W2972284386 hasConceptScore W2972284386C552990157 @default.
• W2972284386 hasConceptScore W2972284386C55493867 @default.
• W2972284386 hasConceptScore W2972284386C62520636 @default.
• W2972284386 hasConceptScore W2972284386C71240020 @default.
• W2972284386 hasConceptScore W2972284386C91881484 @default.
• W2972284386 hasIssue "1" @default.
• W2972284386 hasLocation W29722843861 @default.

• next