FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2972296916> ?p ?o ?g. }

• W2972296916 endingPage "3241" @default.
• W2972296916 startingPage "3241" @default.
• W2972296916 abstract "Breast cancer is the most commonly diagnosed cancer and the leading cause of cancer death among females globally. The tumorigenic activities of cancer cells such as aldehyde dehydrogenase (ALDH) activity and differentiation have contributed to relapse and eventual mortality in breast cancer. Thus, current drug discovery research is focused on targeting breast cancer cells with ALDH activity and their capacity to form secondary tumors. Citral (3,7-dimethyl-2,6-octadienal), from lemon grass (Cymbopogon citrates), has been previously reported to have a cytotoxic effect on breast cancer cells. Hence, this study was conducted to evaluate the in vivo effect of citral in targeting ALDH activity of breast cancer cells. BALB/c mice were challenged with 4T1 breast cancer cells followed by daily oral feeding of 50 mg/kg citral or distilled water for two weeks. The population of ALDH+ tumor cells and their capacity to form secondary tumors in both untreated and citral treated 4T1 challenged mice were assessed by Aldefluor assay and tumor growth upon cell reimplantation in normal mice, respectively. Citral treatment reduced the size and number of cells with ALDH+ activity of the tumors in 4T1-challenged BALB/c mice. Moreover, citral-treated mice were also observed with smaller tumor size and delayed tumorigenicity after reimplantation of the primary tumor cells into normal mice. These findings support the antitumor effect of citral in targeting ALDH+ cells and tumor recurrence in breast cancer cells." @default.
• W2972296916 created "2019-09-12" @default.
• W2972296916 creator A5007715824 @default.
• W2972296916 creator A5009322369 @default.
• W2972296916 creator A5029827968 @default.
• W2972296916 creator A5033372641 @default.
• W2972296916 creator A5044209013 @default.
• W2972296916 date "2019-09-05" @default.
• W2972296916 modified "2023-10-11" @default.
• W2972296916 title "In Vivo Anti-Tumor Effects of Citral on 4T1 Breast Cancer Cells via Induction of Apoptosis and Downregulation of Aldehyde Dehydrogenase Activity" @default.
• W2972296916 cites W1520332974 @default.
• W2972296916 cites W1551407310 @default.
• W2972296916 cites W1917896544 @default.
• W2972296916 cites W1927697688 @default.
• W2972296916 cites W1970002755 @default.
• W2972296916 cites W1986553386 @default.
• W2972296916 cites W2001679453 @default.
• W2972296916 cites W2003402838 @default.
• W2972296916 cites W2019264784 @default.
• W2972296916 cites W2029340236 @default.
• W2972296916 cites W2033061169 @default.
• W2972296916 cites W2041835487 @default.
• W2972296916 cites W2048117957 @default.
• W2972296916 cites W2064164438 @default.
• W2972296916 cites W2076810403 @default.
• W2972296916 cites W2078172132 @default.
• W2972296916 cites W2093634040 @default.
• W2972296916 cites W2102146512 @default.
• W2972296916 cites W2115052440 @default.
• W2972296916 cites W2124218468 @default.
• W2972296916 cites W2124701250 @default.
• W2972296916 cites W2133190520 @default.
• W2972296916 cites W2135822924 @default.
• W2972296916 cites W2158021558 @default.
• W2972296916 cites W2162959148 @default.
• W2972296916 cites W2164423381 @default.
• W2972296916 cites W2164649663 @default.
• W2972296916 cites W2331295681 @default.
• W2972296916 cites W2516839465 @default.
• W2972296916 cites W2806048231 @default.
• W2972296916 cites W2912781962 @default.
• W2972296916 cites W4292169314 @default.
• W2972296916 doi "https://doi.org/10.3390/molecules24183241" @default.
• W2972296916 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6767168" @default.
• W2972296916 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31492037" @default.
• W2972296916 hasPublicationYear "2019" @default.
• W2972296916 type Work @default.
• W2972296916 sameAs 2972296916 @default.
• W2972296916 citedByCount "25" @default.
• W2972296916 countsByYear W29722969162020 @default.
• W2972296916 countsByYear W29722969162021 @default.
• W2972296916 countsByYear W29722969162022 @default.
• W2972296916 countsByYear W29722969162023 @default.
• W2972296916 crossrefType "journal-article" @default.
• W2972296916 hasAuthorship W2972296916A5007715824 @default.
• W2972296916 hasAuthorship W2972296916A5009322369 @default.
• W2972296916 hasAuthorship W2972296916A5029827968 @default.
• W2972296916 hasAuthorship W2972296916A5033372641 @default.
• W2972296916 hasAuthorship W2972296916A5044209013 @default.
• W2972296916 hasBestOaLocation W29722969161 @default.
• W2972296916 hasConcept C121608353 @default.
• W2972296916 hasConcept C126322002 @default.
• W2972296916 hasConcept C150903083 @default.
• W2972296916 hasConcept C154317977 @default.
• W2972296916 hasConcept C181199279 @default.
• W2972296916 hasConcept C190283241 @default.
• W2972296916 hasConcept C202751555 @default.
• W2972296916 hasConcept C203014093 @default.
• W2972296916 hasConcept C207001950 @default.
• W2972296916 hasConcept C25747580 @default.
• W2972296916 hasConcept C2777278459 @default.
• W2972296916 hasConcept C2781370763 @default.
• W2972296916 hasConcept C502942594 @default.
• W2972296916 hasConcept C530470458 @default.
• W2972296916 hasConcept C55493867 @default.
• W2972296916 hasConcept C59822182 @default.
• W2972296916 hasConcept C71924100 @default.
• W2972296916 hasConcept C86803240 @default.
• W2972296916 hasConcept C96232424 @default.
• W2972296916 hasConcept C98274493 @default.
• W2972296916 hasConceptScore W2972296916C121608353 @default.
• W2972296916 hasConceptScore W2972296916C126322002 @default.
• W2972296916 hasConceptScore W2972296916C150903083 @default.
• W2972296916 hasConceptScore W2972296916C154317977 @default.
• W2972296916 hasConceptScore W2972296916C181199279 @default.
• W2972296916 hasConceptScore W2972296916C190283241 @default.
• W2972296916 hasConceptScore W2972296916C202751555 @default.
• W2972296916 hasConceptScore W2972296916C203014093 @default.
• W2972296916 hasConceptScore W2972296916C207001950 @default.
• W2972296916 hasConceptScore W2972296916C25747580 @default.
• W2972296916 hasConceptScore W2972296916C2777278459 @default.
• W2972296916 hasConceptScore W2972296916C2781370763 @default.
• W2972296916 hasConceptScore W2972296916C502942594 @default.
• W2972296916 hasConceptScore W2972296916C530470458 @default.
• W2972296916 hasConceptScore W2972296916C55493867 @default.
• W2972296916 hasConceptScore W2972296916C59822182 @default.
• W2972296916 hasConceptScore W2972296916C71924100 @default.
• W2972296916 hasConceptScore W2972296916C86803240 @default.

• next