FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2972302839> ?p ?o ?g. }

• W2972302839 endingPage "7321" @default.
• W2972302839 startingPage "7307" @default.
• W2972302839 abstract "MicroRNA-675-5p (miR-675-5p) is dysregulated in multiple human cancers, but its involvement in papillary thyroid cancer (PTC) remains to be investigated. This study aimed to examine the expression pattern of miR-675 in PTC, determine the effects of miR-675 on regulating the progression of PTC, and to explore the underlying molecular mechanisms.The expression profile of miR-675 in PTC tissues and cell lines was determined using RT-qPCR. CCK-8, transwell migration and invasion assays, and xenograft tumors in nude mice were employed to analyze proliferation, in vitro migration and invasion, and in vivo tumor growth of PTC cells, respectively. The putative target of miR-675 was predicted using bioinformatic algorithms and was confirmed using luciferase reporter assays, RT-qPCR, and Western blotting.miR-675 expression was decreased in PTC tissues and cell lines. A low level of miR-675 expression was significantly correlated with lymphatic metastasis and TNM stage in PTC patients. Ectopic miR-675 expression suppressed PTC cell proliferation, migration, and invasion in vitro and hindered tumor growth in vivo. Mitogen-activated protein kinase 1 (MAPK1) was found to be the direct target gene of miR-675 in PTC cells. MAPK1 reintroduction negated the tumor-suppressing effect of miR-675 overexpression in PTC cells. Furthermore, the lncRNA mitochondrial RNA processing endoribonuclease (RMRP) functioned as a ceRNA of miR-675 in PTC cells. Silencing RMRP expression inhibited the growth and metastasis of PTC cells by sponging miR-675 and regulating MAPK1.These findings revealed that miR-675 directly targets MAPK1 and is sponged by lncRNA RMRP to inhibit the oncogenicity of PTC, suggesting the RMRP-miR-675-MAPK1 pathway is an effective target for the treatment of PTC patients." @default.
• W2972302839 created "2019-09-12" @default.
• W2972302839 creator A5010258131 @default.
• W2972302839 creator A5024569123 @default.
• W2972302839 creator A5043715028 @default.
• W2972302839 date "2019-09-01" @default.
• W2972302839 modified "2023-09-29" @default.
• W2972302839 title "<p>MicroRNA-675 directly targets MAPK1 to suppress the oncogenicity of papillary thyroid cancer and is sponged by long non-coding RNA RMRP</p>" @default.
• W2972302839 cites W129592507 @default.
• W2972302839 cites W1509784349 @default.
• W2972302839 cites W1920639240 @default.
• W2972302839 cites W1938240656 @default.
• W2972302839 cites W1954988966 @default.
• W2972302839 cites W1969591401 @default.
• W2972302839 cites W1984185945 @default.
• W2972302839 cites W1992865683 @default.
• W2972302839 cites W2028205153 @default.
• W2972302839 cites W2035658605 @default.
• W2972302839 cites W2036043688 @default.
• W2972302839 cites W2062871120 @default.
• W2972302839 cites W2066555699 @default.
• W2972302839 cites W2067447210 @default.
• W2972302839 cites W2076609845 @default.
• W2972302839 cites W2107277218 @default.
• W2972302839 cites W2109544257 @default.
• W2972302839 cites W2117391818 @default.
• W2972302839 cites W2124681173 @default.
• W2972302839 cites W2129450655 @default.
• W2972302839 cites W2139766730 @default.
• W2972302839 cites W2147053822 @default.
• W2972302839 cites W2163642215 @default.
• W2972302839 cites W2185786705 @default.
• W2972302839 cites W2192080449 @default.
• W2972302839 cites W2203508103 @default.
• W2972302839 cites W2208667978 @default.
• W2972302839 cites W2226825560 @default.
• W2972302839 cites W2317361272 @default.
• W2972302839 cites W2353156543 @default.
• W2972302839 cites W2412734405 @default.
• W2972302839 cites W2490315018 @default.
• W2972302839 cites W2522601063 @default.
• W2972302839 cites W2557634106 @default.
• W2972302839 cites W2563227276 @default.
• W2972302839 cites W2570851392 @default.
• W2972302839 cites W2588405574 @default.
• W2972302839 cites W2596944189 @default.
• W2972302839 cites W2617416037 @default.
• W2972302839 cites W2723980678 @default.
• W2972302839 cites W2763277954 @default.
• W2972302839 cites W2769586158 @default.
• W2972302839 cites W2790328757 @default.
• W2972302839 cites W2792783079 @default.
• W2972302839 cites W2794056534 @default.
• W2972302839 cites W2799379109 @default.
• W2972302839 cites W2803041400 @default.
• W2972302839 cites W2807650708 @default.
• W2972302839 cites W2810868291 @default.
• W2972302839 cites W2904944055 @default.
• W2972302839 cites W2906208979 @default.
• W2972302839 cites W2913133797 @default.
• W2972302839 cites W2913804962 @default.
• W2972302839 cites W2914805278 @default.
• W2972302839 cites W2914875381 @default.
• W2972302839 cites W2988545349 @default.
• W2972302839 cites W2989946953 @default.
• W2972302839 doi "https://doi.org/10.2147/ott.s213371" @default.
• W2972302839 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6735657" @default.
• W2972302839 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31564913" @default.
• W2972302839 hasPublicationYear "2019" @default.
• W2972302839 type Work @default.
• W2972302839 sameAs 2972302839 @default.
• W2972302839 citedByCount "26" @default.
• W2972302839 countsByYear W29723028392020 @default.
• W2972302839 countsByYear W29723028392021 @default.
• W2972302839 countsByYear W29723028392022 @default.
• W2972302839 countsByYear W29723028392023 @default.
• W2972302839 crossrefType "journal-article" @default.
• W2972302839 hasAuthorship W2972302839A5010258131 @default.
• W2972302839 hasAuthorship W2972302839A5024569123 @default.
• W2972302839 hasAuthorship W2972302839A5043715028 @default.
• W2972302839 hasBestOaLocation W29723028391 @default.
• W2972302839 hasConcept C104317684 @default.
• W2972302839 hasConcept C119056186 @default.
• W2972302839 hasConcept C121608353 @default.
• W2972302839 hasConcept C126322002 @default.
• W2972302839 hasConcept C145059251 @default.
• W2972302839 hasConcept C153911025 @default.
• W2972302839 hasConcept C2779013556 @default.
• W2972302839 hasConcept C2779761222 @default.
• W2972302839 hasConcept C2781461381 @default.
• W2972302839 hasConcept C39845236 @default.
• W2972302839 hasConcept C502942594 @default.
• W2972302839 hasConcept C54355233 @default.
• W2972302839 hasConcept C55493867 @default.
• W2972302839 hasConcept C62112901 @default.
• W2972302839 hasConcept C71924100 @default.
• W2972302839 hasConcept C86803240 @default.
• W2972302839 hasConceptScore W2972302839C104317684 @default.

• next