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- W2972363908 abstract "Aims: Although paper-pencil based psychometric tests are the gold standard for diagnosis of cognitive dysfunction in liver disease. They take time, and can be affected by age/education level. This study explored sensory integration ability to discriminate cognitive dysfunction in cirrhosis.Methods: Fifty-one healthy and cirrhotic patients were recruited. The sensory integration test presents stimuli from two different sensory modalities (e.g., image and sound) with a short time lag, and subject judge which stimuli appeared first. Repetitive tests reveal the subject’s sensory integration capability. Subjects were compared with conventional psychometric tests (paper and computer based), and functional near-infrared spectroscopy.Results: Sensory integration capability, the perceptual threshold to discriminate the time gap between an image and sound stimulus, was significantly impaired in minimal hepatic encephalopathy (MHE) patients compared to healthy controls (p<0.01) and without MHE (p<0.05). Sensory integration test showed good correlation with conventional psychometric test (NCT-A, r=0.290, p=0.039; NCT-B, r=0.395, p=0.004; DST-B, r=-0.360, p=0.010; ACPT, r=-0.364, p=0.009). Conventional psychometric tests were dependent on age and education level, while the sensory integration test was not affected by demographic factors. The sensory integration test, where a cut-off value for the perceptual threshold was 133.1 ms, recognized patients with MHE at 80% sensitivity and 81% specificity. Conclusions: Sensory integration test showed good correlation with conventional psychometric tests. It showed good ability to discriminate cognitive dysfunction in cirrhotic patients." @default.
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- W2972363908 date "2017-01-01" @default.
- W2972363908 modified "2023-09-23" @default.
- W2972363908 title "PO-033 : Multi-Sensory Integration Impairment in Patients with Minimal Hepatic Encephalopathy" @default.
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