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- W2972381104 abstract "Abstract Multidrug resistance in Gram-negative bacteria can arise by the over-expression of multidrug efflux pumps, which can extrude a wide range of antibiotics. Here we describe the ancestral Haemophilus influenzae efflux pump AcrB (AcrB-Hi). We performed a phylogenetic analysis of hundreds of RND-type transporters. We found that AcrB-Hi is a relatively ancient efflux pump, which nonetheless can export the same range of antibiotics as its evolved colleague from Escherichia coli . AcrB-Hi was not inhibited by the efflux pump inhibitor ABI-PP, and could export bile salts weakly. This points to an environmental adaptation of RND transporters. We also explain the sensitivity of H. influenzae cells to β-lactams and novobiocin by the outer membrane porin OmpP2. This porin counterbalances the AcrB-Hi efflux by leaking the drugs back into the cells. We hypothesise that multidrug recognition by RND-type pumps is not an evolutionarily acquired ability, and has been present since ancient promiscuous transporters." @default.
- W2972381104 created "2019-09-19" @default.
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- W2972381104 date "2019-09-13" @default.
- W2972381104 modified "2023-09-24" @default.
- W2972381104 title "Phylogenetic and functional characterisation of the Haemophilus influenzae multidrug efflux pump AcrB" @default.
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- W2972381104 doi "https://doi.org/10.1038/s42003-019-0564-6" @default.
- W2972381104 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6744504" @default.
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