FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2972382688> ?p ?o ?g. }

• W2972382688 endingPage "108105" @default.
• W2972382688 startingPage "108105" @default.
• W2972382688 abstract "Currently, there is a lack of investigation into the initial signaling events underlying the development of disuse muscle atrophy. The study was aimed to (i) identify an assumed relationship between AMPK dephosphorylation and p70S6K hyperphosphorylation in the initial period of hindlimb unloading (HS), and (ii) assess the signaling consequences of p70S6K hyperphosphorylation following 24-h HS. For experiment 1, rats were treated with AMPK activator (AICAR) for 6 d before HS as well as during 24-h HS. For experiment 2, rats were treated with mTORC1 inhibitor rapamycin during 24-h HS. The key signaling markers implicated in protein turnover were assessed using WB and RT-PCR. One-day HS resulted in a significant upregulation of MuRF-1 and MAFbx expression, increase in p70S6K (Thr389) and IRS-1 (Ser639) phosphorylation and a significant decrease in phosphorylated AMPK, AKT, FOXO3, total IRS-1 content, and HDAC5 nuclear content. AMPK and p70S6K phosphorylation did not differ from control in AICAR-treated unloaded rats. Rapamycin treatment during unloading abolished p70S6K and E3 ligases upregulation and increased HDAC5 nuclear accumulation. The results of the study suggest that mTORC-1/p70S6K signaling pathway in rat soleus muscle is activated following 24-h mechanical unloading. This activation is facilitated by a decrease in AMPK phosphorylation. Increased p70S6K activity at the initial stage of hindlimb unloading could lead to the upregulation of E3 ligases MAFbx/atrogin-1 and MuRF-1 via nuclear export of HDAC5." @default.
• W2972382688 created "2019-09-19" @default.
• W2972382688 creator A5001932478 @default.
• W2972382688 creator A5007516586 @default.
• W2972382688 creator A5011608374 @default.
• W2972382688 creator A5019385340 @default.
• W2972382688 creator A5026803588 @default.
• W2972382688 creator A5027129861 @default.
• W2972382688 date "2019-10-01" @default.
• W2972382688 modified "2023-09-27" @default.
• W2972382688 title "Elevated p70S6K phosphorylation in rat soleus muscle during the early stage of unloading: Causes and consequences" @default.
• W2972382688 cites W1891894117 @default.
• W2972382688 cites W1987626466 @default.
• W2972382688 cites W2004427562 @default.
• W2972382688 cites W2011282245 @default.
• W2972382688 cites W2023470228 @default.
• W2972382688 cites W2033797333 @default.
• W2972382688 cites W2042155632 @default.
• W2972382688 cites W2049686361 @default.
• W2972382688 cites W2050219080 @default.
• W2972382688 cites W2052451590 @default.
• W2972382688 cites W2054720248 @default.
• W2972382688 cites W2056137479 @default.
• W2972382688 cites W2066264056 @default.
• W2972382688 cites W2081638622 @default.
• W2972382688 cites W2081920342 @default.
• W2972382688 cites W2082092138 @default.
• W2972382688 cites W2083849298 @default.
• W2972382688 cites W2110802982 @default.
• W2972382688 cites W2112587264 @default.
• W2972382688 cites W2135792340 @default.
• W2972382688 cites W2137035181 @default.
• W2972382688 cites W2142040365 @default.
• W2972382688 cites W2144491196 @default.
• W2972382688 cites W2147594695 @default.
• W2972382688 cites W2163855569 @default.
• W2972382688 cites W2168492534 @default.
• W2972382688 cites W2173524536 @default.
• W2972382688 cites W2242765960 @default.
• W2972382688 cites W2283701426 @default.
• W2972382688 cites W2462542303 @default.
• W2972382688 cites W2508047226 @default.
• W2972382688 cites W2736198251 @default.
• W2972382688 cites W2762008908 @default.
• W2972382688 cites W2803028423 @default.
• W2972382688 cites W2886609022 @default.
• W2972382688 doi "https://doi.org/10.1016/j.abb.2019.108105" @default.
• W2972382688 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31518555" @default.
• W2972382688 hasPublicationYear "2019" @default.
• W2972382688 type Work @default.
• W2972382688 sameAs 2972382688 @default.
• W2972382688 citedByCount "13" @default.
• W2972382688 countsByYear W29723826882020 @default.
• W2972382688 countsByYear W29723826882021 @default.
• W2972382688 countsByYear W29723826882022 @default.
• W2972382688 countsByYear W29723826882023 @default.
• W2972382688 crossrefType "journal-article" @default.
• W2972382688 hasAuthorship W2972382688A5001932478 @default.
• W2972382688 hasAuthorship W2972382688A5007516586 @default.
• W2972382688 hasAuthorship W2972382688A5011608374 @default.
• W2972382688 hasAuthorship W2972382688A5019385340 @default.
• W2972382688 hasAuthorship W2972382688A5026803588 @default.
• W2972382688 hasAuthorship W2972382688A5027129861 @default.
• W2972382688 hasConcept C104317684 @default.
• W2972382688 hasConcept C11960822 @default.
• W2972382688 hasConcept C126322002 @default.
• W2972382688 hasConcept C127561419 @default.
• W2972382688 hasConcept C134018914 @default.
• W2972382688 hasConcept C168003608 @default.
• W2972382688 hasConcept C178666793 @default.
• W2972382688 hasConcept C181912034 @default.
• W2972382688 hasConcept C185592680 @default.
• W2972382688 hasConcept C2776104385 @default.
• W2972382688 hasConcept C2776263037 @default.
• W2972382688 hasConcept C2776780712 @default.
• W2972382688 hasConcept C2778198054 @default.
• W2972382688 hasConcept C2779959927 @default.
• W2972382688 hasConcept C2780124434 @default.
• W2972382688 hasConcept C55493867 @default.
• W2972382688 hasConcept C62478195 @default.
• W2972382688 hasConcept C71924100 @default.
• W2972382688 hasConcept C75217442 @default.
• W2972382688 hasConcept C86554907 @default.
• W2972382688 hasConcept C86803240 @default.
• W2972382688 hasConcept C95444343 @default.
• W2972382688 hasConcept C97029542 @default.
• W2972382688 hasConcept C98490376 @default.
• W2972382688 hasConceptScore W2972382688C104317684 @default.
• W2972382688 hasConceptScore W2972382688C11960822 @default.
• W2972382688 hasConceptScore W2972382688C126322002 @default.
• W2972382688 hasConceptScore W2972382688C127561419 @default.
• W2972382688 hasConceptScore W2972382688C134018914 @default.
• W2972382688 hasConceptScore W2972382688C168003608 @default.
• W2972382688 hasConceptScore W2972382688C178666793 @default.
• W2972382688 hasConceptScore W2972382688C181912034 @default.
• W2972382688 hasConceptScore W2972382688C185592680 @default.
• W2972382688 hasConceptScore W2972382688C2776104385 @default.
• W2972382688 hasConceptScore W2972382688C2776263037 @default.

• next