FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2972384538> ?p ?o ?g. }

• W2972384538 endingPage "e027850" @default.
• W2972384538 startingPage "e027850" @default.
• W2972384538 abstract "Introduction Sri Lanka has one of the highest incidences of leptospirosis worldwide. We hypothesised that different geographical locations and patient context will have a distinct molecular epidemiology of leptospirosis, based on microgeographical characteristics related to regiona-specific Leptospira predominance. Our objective is to characterise the clinical, epidemiological and molecular aspects of leptospirosis in Sri Lanka to understand disease progression, risk factors and obtain isolates of Leptospira . Methods and analysis We designed a multicentre prospective study in Sri Lanka to recruit undifferentiated febrile patients and conduct follow-ups during hospital stays. Patients will be recruited from outpatient departments and medical wards. This study will be conducted at two main sites (Anuradhapura and Peradeniya) and several additional sites (Awissawella, Ratnapura and Polonnaruwa). Blood and urine will be collected from patients on the day of admission to the ward or presentation to the outpatient department. Bedside inoculation of 2–4 drops of venous blood will be performed with Ellinghausen-McCullough-Johnson-Harris (EMJH) semisolid media supplemented with antibiotics. Regionally optimised microscopic agglutination test, culture and qPCR-evidence will be performed to confirm the presence of Leptospira in blood which in turn will confirm the presence of disease. Whole genome sequencing will be carried out for all isolates recovered from patients. Multilocus sequence typing (MLST) will be used for the genotyping of new isolates. Sri Lankan isolates will be identified using three published MLST schemes for Leptospira . Ethics and dissemination Ethical clearance for the study was obtained from Ethics Review Committees (ERC), Medicine and Allied Sciences (FMAS), Rajarata University of Sri Lanka (RUSL) and University of Peradeniya. All genomic data generated through this project will be available at GenBank. Anonymised data will be deposited at the ERC, FMAS, RUSL." @default.
• W2972384538 created "2019-09-19" @default.
• W2972384538 creator A5010778152 @default.
• W2972384538 creator A5015856008 @default.
• W2972384538 creator A5032374526 @default.
• W2972384538 creator A5038487191 @default.
• W2972384538 creator A5045232780 @default.
• W2972384538 creator A5048907130 @default.
• W2972384538 creator A5049961844 @default.
• W2972384538 creator A5057827709 @default.
• W2972384538 creator A5077554474 @default.
• W2972384538 date "2019-09-01" @default.
• W2972384538 modified "2023-10-16" @default.
• W2972384538 title "Study protocol: characterising the clinical, epidemiological and aetiological aspects of leptospirosis in Sri Lanka: a hospital based clinico-epidemiological study" @default.
• W2972384538 cites W1495820970 @default.
• W2972384538 cites W1523379896 @default.
• W2972384538 cites W1789112843 @default.
• W2972384538 cites W1815051871 @default.
• W2972384538 cites W1948094720 @default.
• W2972384538 cites W1982451112 @default.
• W2972384538 cites W1991776174 @default.
• W2972384538 cites W2019875651 @default.
• W2972384538 cites W2030988668 @default.
• W2972384538 cites W2039946326 @default.
• W2972384538 cites W2047045906 @default.
• W2972384538 cites W2060196753 @default.
• W2972384538 cites W2092313645 @default.
• W2972384538 cites W2094161400 @default.
• W2972384538 cites W2094282156 @default.
• W2972384538 cites W2096093282 @default.
• W2972384538 cites W2096658590 @default.
• W2972384538 cites W2099423928 @default.
• W2972384538 cites W2110047405 @default.
• W2972384538 cites W2112870092 @default.
• W2972384538 cites W2122673596 @default.
• W2972384538 cites W2141559777 @default.
• W2972384538 cites W2143358508 @default.
• W2972384538 cites W2144916185 @default.
• W2972384538 cites W2157143990 @default.
• W2972384538 cites W2158318573 @default.
• W2972384538 cites W2159954944 @default.
• W2972384538 cites W2161896756 @default.
• W2972384538 cites W2169513990 @default.
• W2972384538 cites W2171251530 @default.
• W2972384538 cites W2301462751 @default.
• W2972384538 cites W2304154550 @default.
• W2972384538 cites W2561404400 @default.
• W2972384538 cites W2766771442 @default.
• W2972384538 cites W2949841808 @default.
• W2972384538 cites W856261079 @default.
• W2972384538 doi "https://doi.org/10.1136/bmjopen-2018-027850" @default.
• W2972384538 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6738675" @default.
• W2972384538 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31511281" @default.
• W2972384538 hasPublicationYear "2019" @default.
• W2972384538 type Work @default.
• W2972384538 sameAs 2972384538 @default.
• W2972384538 citedByCount "10" @default.
• W2972384538 countsByYear W29723845382020 @default.
• W2972384538 countsByYear W29723845382021 @default.
• W2972384538 countsByYear W29723845382022 @default.
• W2972384538 countsByYear W29723845382023 @default.
• W2972384538 crossrefType "journal-article" @default.
• W2972384538 hasAuthorship W2972384538A5010778152 @default.
• W2972384538 hasAuthorship W2972384538A5015856008 @default.
• W2972384538 hasAuthorship W2972384538A5032374526 @default.
• W2972384538 hasAuthorship W2972384538A5038487191 @default.
• W2972384538 hasAuthorship W2972384538A5045232780 @default.
• W2972384538 hasAuthorship W2972384538A5048907130 @default.
• W2972384538 hasAuthorship W2972384538A5049961844 @default.
• W2972384538 hasAuthorship W2972384538A5057827709 @default.
• W2972384538 hasAuthorship W2972384538A5077554474 @default.
• W2972384538 hasBestOaLocation W29723845381 @default.
• W2972384538 hasConcept C104317684 @default.
• W2972384538 hasConcept C107130276 @default.
• W2972384538 hasConcept C126322002 @default.
• W2972384538 hasConcept C135763542 @default.
• W2972384538 hasConcept C151730666 @default.
• W2972384538 hasConcept C159654299 @default.
• W2972384538 hasConcept C203014093 @default.
• W2972384538 hasConcept C2778033228 @default.
• W2972384538 hasConcept C2779343474 @default.
• W2972384538 hasConcept C2780542935 @default.
• W2972384538 hasConcept C42972112 @default.
• W2972384538 hasConcept C45189115 @default.
• W2972384538 hasConcept C55493867 @default.
• W2972384538 hasConcept C71924100 @default.
• W2972384538 hasConcept C73878171 @default.
• W2972384538 hasConcept C77434933 @default.
• W2972384538 hasConcept C86803240 @default.
• W2972384538 hasConcept C97669555 @default.
• W2972384538 hasConceptScore W2972384538C104317684 @default.
• W2972384538 hasConceptScore W2972384538C107130276 @default.
• W2972384538 hasConceptScore W2972384538C126322002 @default.
• W2972384538 hasConceptScore W2972384538C135763542 @default.
• W2972384538 hasConceptScore W2972384538C151730666 @default.
• W2972384538 hasConceptScore W2972384538C159654299 @default.
• W2972384538 hasConceptScore W2972384538C203014093 @default.
• W2972384538 hasConceptScore W2972384538C2778033228 @default.

• next