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• W2972398329 abstract "Abstract Vaccine development for mutating pathogens is challenged by their fast evolution, the complexity of immunodominance, and the heterogeneous immune history of individuals. Mathematical models are critical for predicting successful vaccine conditions or designing potent antibodies. Existing models are limited by their abstract and poorly structural representations of antigen epitopes. Here, we propose a structural lattice-based model for antibody–antigen affinity. An efficient algorithm is given that predicts the best binding structure of an antibody’s amino acid sequence around an antigen with shortened computational time. This structural representation contains key physiological properties, such as affinity jumps and cross-reactivity, and successfully reflects the topology of antigen epitopes, such as pockets and shielded residues. It is suitable for large simulations of affinity maturation. We perform in silico immunizations via germinal center simulations and show that our model can explain complex phenomena like recognition of the same epitope by unrelated clones. We show that the use of cocktails of similar epitopes promotes the development of cross-reactive antibodies. This model opens a new avenue for optimizing multivalent vaccines with combined antigen cocktails or sequential immunizations, and to reveal reasons for vaccine success or failure on a structural basis." @default.
• W2972398329 created "2019-09-19" @default.
• W2972398329 creator A5024162635 @default.
• W2972398329 creator A5035993246 @default.
• W2972398329 date "2019-09-12" @default.
• W2972398329 modified "2023-10-17" @default.
• W2972398329 title "A 3D structural affinity model for multi-epitope <i>in silico</i> germinal center simulations" @default.
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• W2972398329 doi "https://doi.org/10.1101/766535" @default.
• W2972398329 hasPublicationYear "2019" @default.
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