Matches in SemOpenAlex for { <https://semopenalex.org/work/W2972416246> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W2972416246 abstract "e22506 Background: Neoadjuvant chemotherapy with intercalated surgery is the standard of care for resectable high-grade bone sarcoma (BS) but identification of biomarkers for chemosensitivity prediction is still needed. Methods: We recruited 121 pts with new primary localized or metastatic BS, measured fasting blood glucose and insulin, body mass index (BMI). The HOMA-IR (Homeostasis Model Assessment) score ((Glucose (mmol/l) x Insulin) / 22.5), which has been proven to reliably detect insulin resistance was calculated, and patients with HOMA-IR > 2.6 were considered as insulin resistant (IR). We collected characteristics usually associated with insulin resistance (IR): age, obesity, diabetes, dyslipidemia and hypertension. Results: Out of 121 pts, 48 (40%) were IR: HOMA-IR > 2.6. Thirty IR patients (62%) had no cardiovascular risk factor. In univariate analysis, IR was associated with obesity (BMI > 30 kg/m 2 )(23% vs 3%, p = 0.0013), but not with age (median 38.4 vs 43.3 years, p = 0.15). IR was more prevalent in Ewing sarcoma (12/21; 57%) and chondrosarcoma (7/13; 54%) followed by osteosarcoma (25/61; 41%) and other rare bone sarcomas (4/26; 15.3%)(p = 0.037). After preoperative chemotherapy and surgery of Ewing tumor and osteosarcoma, pathologic tumor necrosis was higher in IR pts (85.8 vs 69.3%, p = 0.012). Using multivariate linear regression models, IR was independently associated with pathologic tumor necrosis (p = 0.042) but not with obesity (p = 0.55). Conclusions: Our results suggest that tumor-induced metabolic profile may help to discriminate best candidates for preoperative chemotherapy in high-grade bone sarcomas. Further studies are needed to confirm and explain these results." @default.
- W2972416246 created "2019-09-19" @default.
- W2972416246 creator A5005075224 @default.
- W2972416246 creator A5005545439 @default.
- W2972416246 creator A5010804968 @default.
- W2972416246 creator A5014962766 @default.
- W2972416246 creator A5027783041 @default.
- W2972416246 creator A5043315417 @default.
- W2972416246 creator A5044481382 @default.
- W2972416246 creator A5052851032 @default.
- W2972416246 creator A5065121477 @default.
- W2972416246 creator A5066460089 @default.
- W2972416246 creator A5082007912 @default.
- W2972416246 creator A5089571606 @default.
- W2972416246 creator A5091487792 @default.
- W2972416246 creator A5091758691 @default.
- W2972416246 date "2019-05-20" @default.
- W2972416246 modified "2023-09-30" @default.
- W2972416246 title "Metabolic profile and neoadjuvant chemotherapy sensitivity in high-grade bone sarcoma." @default.
- W2972416246 doi "https://doi.org/10.1200/jco.2019.37.15_suppl.e22506" @default.
- W2972416246 hasPublicationYear "2019" @default.
- W2972416246 type Work @default.
- W2972416246 sameAs 2972416246 @default.
- W2972416246 citedByCount "0" @default.
- W2972416246 crossrefType "journal-article" @default.
- W2972416246 hasAuthorship W2972416246A5005075224 @default.
- W2972416246 hasAuthorship W2972416246A5005545439 @default.
- W2972416246 hasAuthorship W2972416246A5010804968 @default.
- W2972416246 hasAuthorship W2972416246A5014962766 @default.
- W2972416246 hasAuthorship W2972416246A5027783041 @default.
- W2972416246 hasAuthorship W2972416246A5043315417 @default.
- W2972416246 hasAuthorship W2972416246A5044481382 @default.
- W2972416246 hasAuthorship W2972416246A5052851032 @default.
- W2972416246 hasAuthorship W2972416246A5065121477 @default.
- W2972416246 hasAuthorship W2972416246A5066460089 @default.
- W2972416246 hasAuthorship W2972416246A5082007912 @default.
- W2972416246 hasAuthorship W2972416246A5089571606 @default.
- W2972416246 hasAuthorship W2972416246A5091487792 @default.
- W2972416246 hasAuthorship W2972416246A5091758691 @default.
- W2972416246 hasConcept C121608353 @default.
- W2972416246 hasConcept C126322002 @default.
- W2972416246 hasConcept C126838900 @default.
- W2972416246 hasConcept C142724271 @default.
- W2972416246 hasConcept C143998085 @default.
- W2972416246 hasConcept C2776694085 @default.
- W2972416246 hasConcept C2777760704 @default.
- W2972416246 hasConcept C2778256501 @default.
- W2972416246 hasConcept C2778292576 @default.
- W2972416246 hasConcept C2909636867 @default.
- W2972416246 hasConcept C530470458 @default.
- W2972416246 hasConcept C71924100 @default.
- W2972416246 hasConceptScore W2972416246C121608353 @default.
- W2972416246 hasConceptScore W2972416246C126322002 @default.
- W2972416246 hasConceptScore W2972416246C126838900 @default.
- W2972416246 hasConceptScore W2972416246C142724271 @default.
- W2972416246 hasConceptScore W2972416246C143998085 @default.
- W2972416246 hasConceptScore W2972416246C2776694085 @default.
- W2972416246 hasConceptScore W2972416246C2777760704 @default.
- W2972416246 hasConceptScore W2972416246C2778256501 @default.
- W2972416246 hasConceptScore W2972416246C2778292576 @default.
- W2972416246 hasConceptScore W2972416246C2909636867 @default.
- W2972416246 hasConceptScore W2972416246C530470458 @default.
- W2972416246 hasConceptScore W2972416246C71924100 @default.
- W2972416246 hasLocation W29724162461 @default.
- W2972416246 hasOpenAccess W2972416246 @default.
- W2972416246 hasPrimaryLocation W29724162461 @default.
- W2972416246 isParatext "false" @default.
- W2972416246 isRetracted "false" @default.
- W2972416246 magId "2972416246" @default.
- W2972416246 workType "article" @default.