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- W2972431724 abstract "Abstract The heart is the first organ formed in the developing fetus, and abnormal development of the heart is a major cause of fetal death. The adverse effects of cigarette smoke on the heart have been well established, but it is not well understood how cigarette smoke components regulate signaling molecules and cardiac specific functions during the early differentiation stage of the embryonic heart. In this study, we identified changes in the size of mouse embryoid bodies (mEBs) in response to treatment with cigarette smoke extract (CSE) via regulation of HDAC2, p53, p21, and cyclin D1 protein expression, which are cardiac differentiation and cell‐cycle markers, respectively. In addition, exposure of mouse embryonic stem cells (mESCs) to cigarette smoke components inhibited myocardial differentiation and development through the expression of HDAC1, HDAC2, GATA4, NKX2‐5, TBX5, HAND1, and Troponin I. Long‐term exposure studies showed that CSE and nicotine may delay the development of mouse cardiomyocytes from mESCs and inhibit the contractibility, which is a fundamental function of the heart. Taken together, these findings suggest that cigarette smoke components, including nicotine, may affect abnormal myocardial differentiation and development." @default.
- W2972431724 created "2019-09-19" @default.
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- W2972431724 date "2019-09-10" @default.
- W2972431724 modified "2023-10-16" @default.
- W2972431724 title "Effects of cigarette smoke components on myocardial differentiation of mouse embryonic stem cells" @default.
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- W2972431724 doi "https://doi.org/10.1002/tox.22843" @default.
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