Matches in SemOpenAlex for { <https://semopenalex.org/work/W2972432881> ?p ?o ?g. }
- W2972432881 abstract "Hydrated magnesium silicate (or talc particles) is a sclerosis agent commonly used in the management of malignant pleural effusions, a common symptom of metastatic diseases, including lung cancers. However, the direct effects of talc particles to lung carcinoma cells, which can be found in the malignant pleural effusion fluids from patients with lung cancer, are not fully understood. Here, we report a study of the signaling pathways that can modulate the cell death and IL-6 secretion induced by talc particles in human lung carcinoma cells. We found that talc-sensitive cells have higher mRNA and protein expression of PI3K catalytic subunits α and β. Further experiments confirmed that modulation (inhibition or activation) of the PI3K pathway reduces or enhances cellular sensitivity to talc particles, respectively, independent of the inflammasome. By knocking down specific PI3K isoforms, we also confirmed that both PI3Kα and -β mediate the observed talc effects. Our results suggest a novel role of the PI3K pathway in talc-induced cell death and IL-6 secretion in lung carcinoma cells. These cellular events are known to drive fibrosis, and thus further studies of the PI3K pathway may provide a better understanding of the mechanisms of talc sclerosis in the malignant pleural space." @default.
- W2972432881 created "2019-09-19" @default.
- W2972432881 creator A5027373447 @default.
- W2972432881 creator A5027725786 @default.
- W2972432881 creator A5034094156 @default.
- W2972432881 creator A5034970322 @default.
- W2972432881 creator A5047207874 @default.
- W2972432881 date "2020-03-01" @default.
- W2972432881 modified "2023-09-23" @default.
- W2972432881 title "PI3K Catalytic Subunits α and β Modulate Cell Death and IL-6 Secretion Induced by Talc Particles in Human Lung Carcinoma Cells" @default.
- W2972432881 cites W1878766934 @default.
- W2972432881 cites W1954313480 @default.
- W2972432881 cites W1964420304 @default.
- W2972432881 cites W1964686609 @default.
- W2972432881 cites W1966079664 @default.
- W2972432881 cites W1967370559 @default.
- W2972432881 cites W1982129714 @default.
- W2972432881 cites W1992477322 @default.
- W2972432881 cites W1997128330 @default.
- W2972432881 cites W2001857521 @default.
- W2972432881 cites W2009004909 @default.
- W2972432881 cites W2009886463 @default.
- W2972432881 cites W2010896859 @default.
- W2972432881 cites W2015477601 @default.
- W2972432881 cites W2015799458 @default.
- W2972432881 cites W2022495797 @default.
- W2972432881 cites W2025364264 @default.
- W2972432881 cites W2030443875 @default.
- W2972432881 cites W2030864103 @default.
- W2972432881 cites W2039487466 @default.
- W2972432881 cites W2040843618 @default.
- W2972432881 cites W2043398720 @default.
- W2972432881 cites W2045142779 @default.
- W2972432881 cites W2045939808 @default.
- W2972432881 cites W2048044810 @default.
- W2972432881 cites W2051017167 @default.
- W2972432881 cites W2054260525 @default.
- W2972432881 cites W2054571187 @default.
- W2972432881 cites W2064942669 @default.
- W2972432881 cites W2070233859 @default.
- W2972432881 cites W2082416335 @default.
- W2972432881 cites W2084687841 @default.
- W2972432881 cites W2090131605 @default.
- W2972432881 cites W2093105965 @default.
- W2972432881 cites W2094189284 @default.
- W2972432881 cites W2104603012 @default.
- W2972432881 cites W2113186524 @default.
- W2972432881 cites W2119429955 @default.
- W2972432881 cites W2120943945 @default.
- W2972432881 cites W2138264320 @default.
- W2972432881 cites W2143141103 @default.
- W2972432881 cites W2153535991 @default.
- W2972432881 cites W2155687923 @default.
- W2972432881 cites W2159905729 @default.
- W2972432881 cites W2166241889 @default.
- W2972432881 cites W2167656141 @default.
- W2972432881 cites W2266150212 @default.
- W2972432881 cites W2415138112 @default.
- W2972432881 cites W2592263473 @default.
- W2972432881 doi "https://doi.org/10.1165/rcmb.2019-0050oc" @default.
- W2972432881 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31513749" @default.
- W2972432881 hasPublicationYear "2020" @default.
- W2972432881 type Work @default.
- W2972432881 sameAs 2972432881 @default.
- W2972432881 citedByCount "2" @default.
- W2972432881 countsByYear W29724328812021 @default.
- W2972432881 countsByYear W29724328812022 @default.
- W2972432881 crossrefType "journal-article" @default.
- W2972432881 hasAuthorship W2972432881A5027373447 @default.
- W2972432881 hasAuthorship W2972432881A5027725786 @default.
- W2972432881 hasAuthorship W2972432881A5034094156 @default.
- W2972432881 hasAuthorship W2972432881A5034970322 @default.
- W2972432881 hasAuthorship W2972432881A5047207874 @default.
- W2972432881 hasConcept C126322002 @default.
- W2972432881 hasConcept C142724271 @default.
- W2972432881 hasConcept C151730666 @default.
- W2972432881 hasConcept C185592680 @default.
- W2972432881 hasConcept C190283241 @default.
- W2972432881 hasConcept C2776232967 @default.
- W2972432881 hasConcept C2776256026 @default.
- W2972432881 hasConcept C2777714996 @default.
- W2972432881 hasConcept C2779979586 @default.
- W2972432881 hasConcept C2781244666 @default.
- W2972432881 hasConcept C31573885 @default.
- W2972432881 hasConcept C49039625 @default.
- W2972432881 hasConcept C502942594 @default.
- W2972432881 hasConcept C55493867 @default.
- W2972432881 hasConcept C62478195 @default.
- W2972432881 hasConcept C71924100 @default.
- W2972432881 hasConcept C86554907 @default.
- W2972432881 hasConcept C86803240 @default.
- W2972432881 hasConcept C95444343 @default.
- W2972432881 hasConceptScore W2972432881C126322002 @default.
- W2972432881 hasConceptScore W2972432881C142724271 @default.
- W2972432881 hasConceptScore W2972432881C151730666 @default.
- W2972432881 hasConceptScore W2972432881C185592680 @default.
- W2972432881 hasConceptScore W2972432881C190283241 @default.
- W2972432881 hasConceptScore W2972432881C2776232967 @default.
- W2972432881 hasConceptScore W2972432881C2776256026 @default.
- W2972432881 hasConceptScore W2972432881C2777714996 @default.