Matches in SemOpenAlex for { <https://semopenalex.org/work/W2972446665> ?p ?o ?g. }
- W2972446665 endingPage "107090" @default.
- W2972446665 startingPage "107090" @default.
- W2972446665 abstract "Clinical studies of drug addiction focus on the reward impact of abused drugs that produces compulsive drug-seeking behavior and drug dependence. However, a small amount of research has examined the opposite effect of aversion to abused drugs to balance the reward effect for drug taking. An aversive behavioral model of abused drugs in terms of conditioned taste aversion (CTA) was challenged by the reward comparison hypothesis (Grigson, 1997). To test the reward comparison hypothesis, the present study examined the rewarding or aversive neural substrates involved in methamphetamine-induced conditioned suppression. The behavioral data showed that methamphetamine induced conditioned suppression on conditioning and reacquisition but extinguished it on extinction. A higher level of stressful aversive corticosterone occurred on conditioning and reacquisition but not extinction. The c-Fos or p-ERK immunohistochemical activity showed that the cingulated cortex area 1 (Cg1), infralimbic cortex (IL), prelimbic cortex (PrL), basolateral amygdala (BLA), nucleus accumbens (NAc), and dentate gyrus (DG) of the hippocampus were overexpressed in aversive CTA induced by methamphetamine. These data may indicate that the Cg1, IL, PrL, BLA, NAc, and DG probably mediated the paradoxical effect—reward and aversion. Altogether, our data conflicted with the reward comparison hypothesis, and methamphetamine may simultaneously induce the paradoxical effect of reward and aversion in the brain to support the paradoxical effect hypothesis of abused drugs. The present data implicate some insights for drug addiction in clinical aspects." @default.
- W2972446665 created "2019-09-19" @default.
- W2972446665 creator A5010430530 @default.
- W2972446665 creator A5018926691 @default.
- W2972446665 creator A5019297577 @default.
- W2972446665 creator A5019543436 @default.
- W2972446665 creator A5040880073 @default.
- W2972446665 creator A5060577749 @default.
- W2972446665 creator A5078277153 @default.
- W2972446665 date "2019-12-01" @default.
- W2972446665 modified "2023-10-15" @default.
- W2972446665 title "Involvement of neural substrates in reward and aversion to methamphetamine addiction: Testing the reward comparison hypothesis and the paradoxical effect hypothesis of abused drugs" @default.
- W2972446665 cites W149290994 @default.
- W2972446665 cites W1872913649 @default.
- W2972446665 cites W1966748410 @default.
- W2972446665 cites W1973139770 @default.
- W2972446665 cites W1973768615 @default.
- W2972446665 cites W1975485560 @default.
- W2972446665 cites W1975836627 @default.
- W2972446665 cites W1976213197 @default.
- W2972446665 cites W1980890656 @default.
- W2972446665 cites W1985399027 @default.
- W2972446665 cites W1989639419 @default.
- W2972446665 cites W1990726113 @default.
- W2972446665 cites W1991784679 @default.
- W2972446665 cites W1993354941 @default.
- W2972446665 cites W1995995989 @default.
- W2972446665 cites W1998805404 @default.
- W2972446665 cites W2000444863 @default.
- W2972446665 cites W2000480440 @default.
- W2972446665 cites W2001553620 @default.
- W2972446665 cites W2004124667 @default.
- W2972446665 cites W2009680578 @default.
- W2972446665 cites W2010409955 @default.
- W2972446665 cites W2015174800 @default.
- W2972446665 cites W2016946492 @default.
- W2972446665 cites W2017866170 @default.
- W2972446665 cites W2021469534 @default.
- W2972446665 cites W2021534324 @default.
- W2972446665 cites W2026569264 @default.
- W2972446665 cites W2027808613 @default.
- W2972446665 cites W2030780744 @default.
- W2972446665 cites W2032242574 @default.
- W2972446665 cites W2032997620 @default.
- W2972446665 cites W2037223564 @default.
- W2972446665 cites W2041697797 @default.
- W2972446665 cites W2042432388 @default.
- W2972446665 cites W2042640084 @default.
- W2972446665 cites W2045053218 @default.
- W2972446665 cites W2045821490 @default.
- W2972446665 cites W2049791338 @default.
- W2972446665 cites W2052201958 @default.
- W2972446665 cites W2055094520 @default.
- W2972446665 cites W2058877488 @default.
- W2972446665 cites W2061444930 @default.
- W2972446665 cites W2065915664 @default.
- W2972446665 cites W2068406343 @default.
- W2972446665 cites W2072698517 @default.
- W2972446665 cites W2072847743 @default.
- W2972446665 cites W2072859457 @default.
- W2972446665 cites W2073615755 @default.
- W2972446665 cites W2076184516 @default.
- W2972446665 cites W2080125844 @default.
- W2972446665 cites W2080481456 @default.
- W2972446665 cites W2083781846 @default.
- W2972446665 cites W2086361382 @default.
- W2972446665 cites W2089376176 @default.
- W2972446665 cites W2091593512 @default.
- W2972446665 cites W2091680313 @default.
- W2972446665 cites W2097066347 @default.
- W2972446665 cites W2100804779 @default.
- W2972446665 cites W2104537532 @default.
- W2972446665 cites W2109518858 @default.
- W2972446665 cites W2116965419 @default.
- W2972446665 cites W2119588121 @default.
- W2972446665 cites W2127801785 @default.
- W2972446665 cites W2129176481 @default.
- W2972446665 cites W2129489490 @default.
- W2972446665 cites W2145078736 @default.
- W2972446665 cites W2150083419 @default.
- W2972446665 cites W2167219760 @default.
- W2972446665 cites W2193187367 @default.
- W2972446665 cites W2194155427 @default.
- W2972446665 cites W2281932216 @default.
- W2972446665 cites W2324006356 @default.
- W2972446665 cites W2333088994 @default.
- W2972446665 cites W2468781160 @default.
- W2972446665 cites W2509705581 @default.
- W2972446665 cites W2519114008 @default.
- W2972446665 cites W2529942677 @default.
- W2972446665 cites W2555970512 @default.
- W2972446665 cites W2619748449 @default.
- W2972446665 cites W2619887862 @default.
- W2972446665 cites W2622542344 @default.
- W2972446665 cites W2735712333 @default.
- W2972446665 cites W2759224356 @default.
- W2972446665 cites W2769890869 @default.
- W2972446665 cites W2784903304 @default.